Identification and analysis of interferon stimulated genes in the uterus

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K15644
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 42010:Animal production science-related
• Research Institution: Hokkaido University
• Principal Investigator: Bai Hanako 北海道大学, 農学研究院, 助教 (60775443)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: ウシ / 子宮 / インターフェロン誘導性遺伝子

Outline of Final Research Achievements

The objective of this study was to obtain the basic knowledge to elucidate the interaction between the embryo and the maternal uterus in order to improve the pregnancy rate. First, treatment of IFNT were conducted on bovine endometrial cells to identify novel ISGs whose expression is induced in endometrial cells at the protein level. Then, functional analysis of ISGs candidates in uterine endometrial cells was performed. Although there have been some changes from the original plan, the ISGs candidates currently under analysis will continue to be validated.

Free Research Field

妊娠、着床

Academic Significance and Societal Importance of the Research Achievements

インターフェロン・タウは反芻動物に特異的な妊娠認識物質であるが、妊娠成立時のI型インターフェロンおよびインターフェロン誘導性遺伝子（ISGs）の発現はヒトやマウスを含む哺乳動物に広く共通している。本研究で新たに着目したISG候補も、過去の知見からヒトでの発現が確認されているため、今後もさらに機能解析を進めることにより、将来的に家畜生産からヒトの生殖医療にも広く貢献できる可能性があると考えている。