Radiopaque microsphere with antibacterial and analgesic effect; from bench to clinic

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K16806
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Aichi Medical University
• Principal Investigator: Narita Akiko 愛知医科大学, 医学部, 助教 (00762080)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: SAP-MS / 血管塞栓術 / 塞栓物質 / 薬剤溶出ビーズ / デリバリーシステム

Outline of Final Research Achievements

Superabsorbent polymer microspheres (SAP-MS) have been clinically used for the treatment as drug-eluting beads. In this study, SAP-MS were suspended in drug solutions: contrast material, antibiotics, analgesics and their mixture, and the characteristics of drug-loaded SAP-MS such as drug absorption, drug release, diameter, and visibility were examined in vitro.
SAP-MS absorbed and released contrast material, antibiotics and analgesics although the degree varied with each drug and drug combination. The diameter of SAP-MS increased for approximately 15 min and then came to an equilibrium. SAP-MS containing contrast material were visible under X-ray imaging.
Although it was possible to create microsphere with visible and various drug-eluting ability, further in vivo studies are needed.

Free Research Field

放射線科学

Academic Significance and Societal Importance of the Research Achievements

本研究では視認可能かつ各種薬剤の溶出能を有する球状塞栓物質の作成が可能であった。
抗生剤や鎮痛剤の薬剤溶出が確認できたため、感染の予防や治療、除痛等が可能となり、新たな治療法になりうると考える。また、X線透視下で視認可能であったことは経験によるところが大きいと言われる塞栓の状況判断を容易にし、治療効果と安全性の向上に加え、技術の均一化に寄与すると考える。