Virtual reality as a novel therapy to prevent post operative derilium in intensive care unit

2021 Fiscal Year Research-status Report

• Project/Area Number: 20K17858
• Research Institution: Mie University
• Principal Investigator: 江角 亮 三重大学, 医学部附属病院, 助教 (50813028)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: Virtual Reality / 仮想現実感 / ICUせん妄 / 鎮痛 / 睡眠障害 / clock gene / ICDSC

Outline of Annual Research Achievements

手術後に患者がICUへ入室すると、環境変化、睡眠サイクルの乱れが引き起こされ、術後せん妄発生率が上昇する。いったんせん妄を発症すると患者の死亡率の上昇など予後悪化につながる。いままで薬物療法や環境改善などさまざまな介入が試みられてきたが、ICUで行える対策、特に環境改善には現実的限界があり、新規テクノロジーの介入が期待される。　近年、VR（Virtual Reality: 仮想現実感）が良好な睡眠促進作用、鎮痛、不安除去など様々なストレス軽減効果を有することが証明され、熱傷、外傷、精神疾患の患者に臨床応用され始めた。　本研究では、ICUで行える環境改善の現実的限界（例：美しい浜辺でリラックスしたいという患者の希望）を、没入型VRの強力な仮想現実感で乗り越えることを目指す。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

外傷患者と外傷術後患者10名に対してVRの介入試験を行い、鎮痛効果、睡眠障害の改善、さらに交感神経、副交感神経のバランスの調整に有効である可能性を示唆するデータを得た。

Strategy for Future Research Activity

患者数を増やして前向き介入試験を続ける予定。

Causes of Carryover

ICU入室患者の患者データを集積したが、データ収集において当初の計画よりも低価格で可能だったため。ICDSCを含む患者データ解析機器に使用する予定である。

Research Products

• [Journal Article] miRNA-200c-3p targets talin-1 to regulate integrin-mediated cell adhesion (2021)
  • Author(s): Obeng Gideon、Park Eun Jeong、Appiah Michael G.、Kawamoto Eiji、Gaowa Arong、Shimaoka Motomu
  • Journal Title: Scientific Reports Volume: 11 Pages: 1～11
  • DOI: 10.1038/s41598-021-01143-3
  • Peer Reviewed / Open Access
• [Journal Article] Substrate stiffness modulates endothelial cell function via the YAP-Dll4-Notch1 pathway (2021)
  • Author(s): Matsuo Eri、Okamoto Takayuki、Ito Atsushi、Kawamoto Eiji、Asanuma Kunihiro、Wada Koichiro、Shimaoka Motomu、Takao Motoshi、Shimamoto Akira
  • Journal Title: Experimental Cell Research Volume: 408 Pages: 112835～112835
  • DOI: 10.1016/j.yexcr.2021.112835
  • Peer Reviewed / Open Access
• [Journal Article] Recombinant soluble thrombomodulin accelerates epithelial stem cell proliferation in mouse intestinal organoids and promotes the mucosal healing in colitis (2021)
  • Author(s): Gaowa Arong、Park Eun Jeong、Kawamoto Eiji、Qin Yan、Shimaoka Motomu
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 36 Pages: 3149～3157
  • DOI: 10.1111/jgh.15656
  • Peer Reviewed / Open Access
• [Journal Article] Cytoskeletal Actin Structure in Osteosarcoma Cells Determines Metastatic Phenotype via Regulating Cell Stiffness, Migration, and Transmigration (2021)
  • Author(s): Kita Kouji、Asanuma Kunihiro、Okamoto Takayuki、Kawamoto Eiji、Nakamura Koichi、Hagi Tomohito、Nakamura Tomoki、Shimaoka Motomu、Sudo Akihiro
  • Journal Title: Current Issues in Molecular Biology Volume: 43 Pages: 1255～1266
  • DOI: 10.3390/cimb43030089
  • Peer Reviewed / Open Access
• [Journal Article] Elevated Plasma Soluble PD-L1 Levels in Out-of-Hospital Cardiac Arrest Patients (2021)
  • Author(s): Sumiyoshi Miho、Kawamoto Eiji、Nakamori Yuki、Esumi Ryo、Ikejiri Kaoru、Shinkai Toru、Akama Yuichi、Ito-Masui Asami、Imai Hiroshi、Gaowa Arong、Park Eun Jeong、Shimaoka Motomu
  • Journal Title: Journal of Clinical Medicine Volume: 10 Pages: 4188～4188
  • DOI: 10.3390/jcm10184188
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial connexin-integrin crosstalk in vascular inflammation (2021)
  • Author(s): Okamoto Takayuki、Park Eun Jeong、Kawamoto Eiji、Usuda Haruki、Wada Koichiro、Taguchi Akihiko、Shimaoka Motomu
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Volume: 1867 Pages: 166168～166168
  • DOI: 10.1016/j.bbadis.2021.166168
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and predictors of direct discharge home following hospitalization of patients with serious adverse events managed by the rapid response system in Japan: a multicenter, retrospective, observational study (2021)
  • Author(s): Takashi Hongo, Hiromichi Naito, Toshifumi Fujiwara, Takaki Naito, Yosuke Homma, Yoshihisa Fujimoto, Morooka Takaya, Yuji Yamamori, Taka-Aki Nakada, Tsuyoshi Nojima, Atsunori Nakao, Shigeki Fujitani
  • Journal Title: Acute Medicine and Surgery Volume: 8 Pages: 1～8
  • DOI: 10.1002/ams2.690
  • Peer Reviewed / Open Access
• [Journal Article] Cellular and Exosomal Regulations of Sepsis-Induced Metabolic Alterations (2021)
  • Author(s): Appiah Michael G.、Park Eun Jeong、Akama Yuichi、Nakamori Yuki、Kawamoto Eiji、Gaowa Arong、Shimaoka Motomu
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Pages: 8295～8295
  • DOI: 10.3390/ijms22158295
  • Peer Reviewed / Open Access
• [Journal Article] Sociometric wearable devices for studying human behavior in corporate and healthcare workplaces (2021)
  • Author(s): Ito-Masui Asami、Kawamoto Eiji、Esumi Ryo、Imai Hiroshi、Shimaoka Motomu
  • Journal Title: BioTechniques Volume: 71 Pages: 392～399
  • DOI: 10.2144/btn-2020-0160
  • Peer Reviewed / Open Access
• [Journal Article] Irisin supports integrin-mediated cell adhesion of lymphocytes (2021)
  • Author(s): Myint Phyoe Kyawe、Ito Atsushi、Appiah Michael G.、Obeng Gideon、Darkwah Samuel、Kawamoto Eiji、Gaowa Arong、Park Eun Jeong、Shimaoka Motomu
  • Journal Title: Biochemistry and Biophysics Reports Volume: 26 Pages: 100977～100977
  • DOI: 10.1016/j.bbrep.2021.100977
  • Peer Reviewed / Open Access
• [Journal Article] Ligand-competent fractalkine receptor is expressed on exosomes (2021)
  • Author(s): Park Eun Jeong、Myint Phyoe Kyawe、Appiah Michael G.、Worawattananutai Patsorn、Inprasit Janjira、Prajuabjinda Onmanee、Soe Zay Yar、Gaowa Arong、Kawamoto Eiji、Shimaoka Motomu
  • Journal Title: Biochemistry and Biophysics Reports Volume: 26 Pages: 100932～100932
  • DOI: 10.1016/j.bbrep.2021.100932
  • Peer Reviewed / Open Access
• [Journal Article] Randomized trial of granulocyte colony-stimulating factor for spinal cord injury (2021)
  • Author(s): Masao Koda, Hideki Hanaoka, Yasuhisa Fujii, Michiko Hanawa, Yohei Kawasaki, Yoshihito Ozawa, Tadami Fujiwara, Hiroyuki Katoh, Yukihiro Matsuyama, Tomohiko Hasegawa, Go Yoshida, Hideyuki Arima, Yu Yamato, Shin Oe, Daisuke Togawa, Sho Kobayashi, Koji Akeda, Eiji Kawamoto, Hiroshi Imai, et al
  • Journal Title: Brain Volume: 144 Pages: 789～799
  • DOI: 10.1093/brain/awaa466
  • Peer Reviewed / Open Access
• [Journal Article] The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells (2021)
  • Author(s): Park Eun Jeong、Myint Phyoe Kyawe、Appiah Michael Gyasi、Darkwah Samuel、Caidengbate Siqingaowa、Ito Atsushi、Matsuo Eri、Kawamoto Eiji、Gaowa Arong、Shimaoka Motomu
  • Journal Title: Viruses Volume: 13 Pages: 645～645
  • DOI: 10.3390/v13040645
  • Peer Reviewed / Open Access
• [Journal Article] The characteristics, types of intervention, and outcomes of postoperative patients who required rapid response system intervention: a nationwide database analysis (2021)
  • Author(s): Sento Yoshiki、In-Hospital Emergency Study Group、Arai Masayasu、Yamamori Yuji、Fujiwara Shinsuke、Tamashiro Masahiro、Kawamoto Eiji、Naito Takaki、Atagi Kazuaki、Fujitani Shigeki、Osaga Satoshi、Sobue Kazuya
  • Journal Title: Journal of Anesthesia Volume: 35 Pages: 222～231
  • DOI: 10.1007/s00540-021-02900-4
  • Peer Reviewed / Open Access
• [Journal Article] Internet-Based Individualized Cognitive Behavioral Therapy for Shift Work Sleep Disorder Empowered by Well-Being Prediction: Protocol for a Pilot Study (2021)
  • Author(s): Ito-Masui Asami、Kawamoto Eiji、Sakamoto Ryota、Yu Han、Sano Akane、Motomura Eishi、Tanii Hisashi、Sakano Shoko、Esumi Ryo、Imai Hiroshi、Shimaoka Motomu
  • Journal Title: JMIR Research Protocols Volume: 10 Pages: e24799～e24799
  • DOI: 10.2196/24799
  • Peer Reviewed / Open Access
• [Journal Article] Veno-arterial extracorporeal membrane oxygenation and targeted temperature management in tricyclic antidepressant-induced cardiac arrest (2021)
  • Author(s): Ikejiri Kaoru、Akama Yuichi、Ieki Yohei、Kawamoto Eiji、Suzuki Kei、Yokoyama Kazuto、Ishikura Ken、Imai Hiroshi
  • Journal Title: Medicine Volume: 100 Pages: e24980～e24980
  • DOI: 10.1097/MD.0000000000024980
  • Peer Reviewed / Open Access
• [Journal Article] Sepsis Induces Deregulation of IL-13 Production and PD-1 Expression in Lung Group 2 Innate Lymphoid Cells (2021)
  • Author(s): Akama Yuichi、Park Eun Jeong、Satoh-Takayama Naoko、Gaowa Arong、Ito Atsushi、Kawamoto Eiji、Darkwah Samuel、Appiah Michael G.、Myint Phyoe Kyawe、Ohno Hiroshi、Imai Hiroshi、Shimaoka Motomu
  • Journal Title: Shock Volume: 55 Pages: 357～370
  • DOI: 10.1097/SHK.0000000000001647
  • Peer Reviewed / Open Access
• [Journal Article] Remodeling of Bone Marrow Niches and Roles of Exosomes in Leukemia (2021)
  • Author(s): Yamaguchi Takanori、Kawamoto Eiji、Gaowa Arong、Park Eun Jeong、Shimaoka Motomu
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Pages: 1881～1881
  • DOI: 10.3390/ijms22041881
  • Peer Reviewed / Open Access
• [Journal Article] The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin (2021)
  • Author(s): Kawamoto Eiji、Nago Nodoka、Okamoto Takayuki、Gaowa Arong、Masui-Ito Asami、Akama Yuichi、Darkwah Samuel、Appiah Michael Gyasi、Myint Phyoe Kyawe、Obeng Gideon、Ito Atsushi、Caidengbate Siqingaowa、Esumi Ryo、Yamaguchi Takanori、Park Eun Jeong、Imai Hiroshi、Shimaoka Motomu
  • Journal Title: Biomedicines Volume: 9 Pages: 162～162
  • DOI: 10.3390/biomedicines9020162
  • Peer Reviewed / Open Access
• [Journal Article] Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, Irisin (2021)
  • Author(s): Darkwah Samuel、Park Eun Jeong、Myint Phyoe Kyawe、Ito Atsushi、Appiah Michael G.、Obeng Gideon、Kawamoto Eiji、Shimaoka Motomu
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 9 Pages: 1～15
  • DOI: 10.3389/fcell.2021.634853
  • Peer Reviewed / Open Access
• [Journal Article] Methods to Study Integrin Functions on Exosomes (2021)
  • Author(s): Kawamoto Eiji、Park Eun Jeong、Shimaoka Motomu
  • Journal Title: Methods to Study Integrin Functions on Exosomes Volume: 1 Pages: 265～281
  • DOI: 10.1007/978-1-0716-0962-0_15
  • Peer Reviewed / Open Access