Analysis of primary cilia in endometrial carcinomas

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18226
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Nagoya City University
• Principal Investigator: KOJIMA RYUJI 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (80833558)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 一次繊毛 / 子宮内膜癌 / OFD1 / p62

Outline of Final Research Achievements

To the best of our knowledge, this is the first study concerning the distribution of primary cilia in normal endometrium and endometrial cancer tissues. Overall, fewer ciliated cells in the highly malignant endometrial cancer tissues may be
associated not only to the proliferation of cancer cells, but also to the　excessive accumulation of OFD1 due to dysfunctional autophagy.

Free Research Field

婦人科腫瘍

Academic Significance and Societal Importance of the Research Achievements

細胞周期を制御しているとされる一次繊毛と子宮内膜組織および子宮内膜癌組織との関連を初めて報告した研究である。一次繊毛と腫瘍増殖との関連についてさらなる研究を進めることで、悪性腫瘍の早期診断や新規治療バイオマーカーの開発につながる研究である