2023 Fiscal Year Final Research Report
Establishing a precision functional molecular design system utilizing a structural informatics approach
| Project/Area Number |
20K20596
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| Research Category |
Grant-in-Aid for Challenging Research (Pioneering)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 49:Pathology, infection/immunology, and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2020-07-30 – 2024-03-31
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| Keywords | ウイルス学 / 構造生物学 / 感染阻害 / 分子デザイン |
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| Outline of Final Research Achievements |
In this study, we attempted to establish a precision molecular design system tailored to target information at the peptide and protein level, and to explore molecular design technology by combining it with structural analysis of target proteins as well. Consequently, we have succeeded in isolating and producing highly functional molecules and elucidating their mechanisms of action by designing them based on the structural information of prefusion and postfusion structures of viral membrane fusion proteins, and specific inhibitory molecules, peptides, and antibodies against viral glycoproteins related to cell entry.
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| Free Research Field |
ウイルス学
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| Academic Significance and Societal Importance of the Research Achievements |
新型コロナウイルスによるパンデミックを筆頭に、ウイルス感染症による社会的・人的損失は非常に大きい。しかし、治療薬やワクチンを理論的にデザインする手法は未だに確立したものが無く試行錯誤が続いている。本研究では、構造情報を利用した精密な分子設計システム構築に挑戦し、感染症創薬に貢献できる構造情報の取得とデザイン技術の構築を行った。これらの技術・情報は理論的な治療薬やワクチン開発に貢献することが期待される。
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