IPMN as a risk factor for pancreatic ductal adenocarcinoma; challenge for early diagnosis of pancreatic cancer by the assessment of clonal expansion

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K21633
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: Kagoshima University
• Principal Investigator: Ohtsuka Takao 鹿児島大学, 医歯学域医学系, 教授 (20372766)
• Co-Investigator(Kenkyū-buntansha): 山口 浩 東京医科大学, 医学部, 兼任准教授 (20510697) ; 三森 功士 九州大学, 大学病院, 教授 (50322748) ; 又木 雄弘 鹿児島大学, 鹿児島大学病院, 特任講師 (10444902) ; 蔵原 弘 鹿児島大学, 医歯学域医学系, 准教授 (70464469)
• Project Period (FY): 2020-07-30 – 2022-03-31
• Keywords: 膵癌 / IPMN / ゲノム / 予防 / ゲノム医療 / クローン拡大 / 早期診断

Outline of Final Research Achievements

We found the driver gene mutation namely XXX (unpublished data) which lead sustained benign intraductal papillary mucinous neoplasm (IPMN). The preliminary experiments demonstrated that this mutation was observed only in IPMN having concomitant pancreatic ductal adenocarcinoma (PDAC), but not in IPMN without PDAC. This finding indicates that there possibly exists the clonal expansion in whole pancreatic parenchyma having IPMN with concomitant PDAC.

Free Research Field

恒常性維持機関の外科学およびその関連分野

Academic Significance and Societal Importance of the Research Achievements

危険因子を有する膵癌発癌過程の機序を解明する学問的意義のみならず、膵癌早期診断法の技術を世界へ向けて発信し、広く世界人類の健康に大きく寄与する社会的意義も有する