Influence of caesarean section on susceptibility to allergy

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22788
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0803:Pathology, infection/immunology, and related fields
• Research Institution: Keio University
• Principal Investigator: YAMADA TAKAHIRO 慶應義塾大学, 薬学部(芝共立), 特任助教 (50881207)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: 帝王切開 / アレルギー / 腸内細菌 / 免疫

Outline of Final Research Achievements

Accumulating studies have suggested that caesarean section increases the risk of allergic diseases, however, the causal relationship and the mechanism are unknown. In this study, by taking advantages of our caesarean section model mice, we investigated influences of caesarean section on gut microbiota and immune system development.

Free Research Field

腸内細菌

Academic Significance and Societal Importance of the Research Achievements

帝王切開とアレルギー感受性の関連が明らかになることで、有効な疾患制御法の開発に繋がる。例えば腸内細菌のバランス異常が原因であった場合、帝王切開出生児の腸内細菌のモニタリング、必要に応じてアレルギー感受性低下につながる細菌を投与することで発症を防ぐことができる可能性がある。また本研究によって、出生時点での環境が長期的な免疫系の発達に及ぼす影響の一端が明らかになった。