Development to the bone regenerative medicine of the porous carbonate apatite by controlling the carbonate contents

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K23112
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: The University of Tokushima
• Principal Investigator: AKITA Kazuya 徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (70876028)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: 炭酸アパタイト / 炭酸含有量 / スキャフォールド

Outline of Final Research Achievements

The aim of this study was to fabricate the scaffold for the newly bone regenerative medicine which could adjust the promotion of bone formation and absorbency of the carbonic apatite by controlling the carbonate contents of the porous carbonate apatite granule which could be absorbed and replaced with the bone. I succeeded in adjustment of the carbonate contents by changing the temperature of the phosphoric acid solution to use in a process of the carbonate apatite production. The carbonate contents increased and the crystal characteristics became low as the phosphorylation temperature lowered. Granules tended to be absorbed and to be replaced bone so that there was much carbonate contents by the histological observation. Moreover, I fabricated the carbonate apatite and the marrow stem cell composites, which found the possibility as the scaffold.

Free Research Field

生体材料

Academic Significance and Societal Importance of the Research Achievements

多孔質炭酸アパタイト顆粒は顆粒内外からの優れた骨形成が望め、さらにそれ自身が骨に置換するという特徴により、体内に残留しない理想的な新規骨再生医療用スキャフォールドになり得ると考えている。しかし、スキャフォールドは使用する部位によって、吸収速度を調節する必要があり、また骨形成もさらに亢進させる方が望ましい。そのためには、含まれる炭酸基量を調整することが必須である。そこで本研究では炭酸基量の異なる多孔質炭酸アパタイト顆粒を開発し，その物性評価と生体内での挙動を評価し、さらにスキャフォールドとしての有用性を評価した。