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2022 Fiscal Year Final Research Report

Development of selective and sensitive multi-analyte detection technology for diagnosis of mosquito-borne viral diseases

Research Project

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Project/Area Number 20KK0115
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 28:Nano/micro science and related fields
Research InstitutionShizuoka University

Principal Investigator

Enoch Y. Park  静岡大学, グリーン科学技術研究所, 教授 (90238246)

Co-Investigator(Kenkyū-buntansha) 加藤 竜也  静岡大学, 農学部, 教授 (00397366)
宮崎 剛亜  静岡大学, グリーン科学技術研究所, 助教 (30775721)
Project Period (FY) 2020-10-27 – 2023-03-31
Keywordsvirus detection / impedance / amperometry / dengue / zika / chikungunya
Outline of Final Research Achievements

In this study, we developed a highly sensitive and rapid detection technology for mosquito-borne disease-related viruses, which are considered to be of public health importance, using a unique electrode that captures the presence of viruses as an electrical signal. Viruses were detected with high sensitivity by electrodes based on gold nanoparticles and polyaniline nanocomposites with antibody conjugation and measuring electrochemical impedance or current. We have also achieved these results with screen-printed electrodes and have successfully detected dengue virus in clinical specimens from dengue patients using a palm-sized detection device.
For this purpose, we have conducted this research in close collaboration with researchers in the National Research and Innovation Agency, Indonesia, and the Indian Council of Medical Research, India.

Free Research Field

ナノバイオ科学

Academic Significance and Societal Importance of the Research Achievements

主に熱帯・亜熱帯地域を中心に発症するデング熱やチクングニア熱は、年間約3億人が媒介蚊によって感染し、常に脅威に曝されている。最も重要な基本原則はグローバルな見地から正確な情報を迅速に伝達するための革新的な早期診断法の開発である。本研究では、ウイルスの存在を電気シグナルとして捉える独創的な使い捨て電極を開発し、手のひらサイズの検出装置でデング熱患者の臨床検体からデングウイルス感染の有無の判定に成功した。本研究を遂行するために、インドネシアやインドの研究者との緊密な連携を行った。本研究成果は、オンサイトで蚊媒介感染症原因ウイルスの検出を可能にし、今後サーベランス強化に寄与すると考えられる。

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Published: 2024-01-30  

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