2022 Fiscal Year Final Research Report
Developing a new control measure of malaria by adjusting host nutrition
| Project/Area Number |
20KK0180
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 49:Pathology, infection/immunology, and related fields
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
青沼 宏佳 東京慈恵会医科大学, 医学部, 講師 (60451457)
齊木 選射 東京慈恵会医科大学, 医学部, 助教 (70738971)
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| Project Period (FY) |
2020-10-27 – 2023-03-31
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| Keywords | マラリア / アミノ酸 / 宿主 / 赤血球 / 栄養 / 代謝 / イソロイシン |
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| Outline of Final Research Achievements |
Malaria is an infectious disease caused by infection with Plasmodium parasites, such as Plasmodium falciparum. Malaria parasites depend on the blood of infected hosts for nutritional requirements for growth and differentiation. Focusing on the interaction between host nutrient metabolism dynamics and malaria pathogenicity, through the analysis of comprehensive concentration patterns of free amino acids in the plasma of malaria-infected patients, we demonstrated the effect of changes in blood isoleucine on cerebral malaria symptoms, which may be due to the reduction of immune cells and the appearance of small red blood cells.
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| Free Research Field |
寄生虫学
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| Academic Significance and Societal Importance of the Research Achievements |
得られた研究成果は、栄養素の中でも寄生虫と宿主の共通通貨とも言えるアミノ酸に焦点を当てることにより、予防・診断・治療法の研究開発において、マラリアだけに限らず多種多様な感染症への適用が可能であることを強く示している。アミノ酸等の宿主の栄養学的知見に基づく感染症制御に向けた新たな研究基盤は、食餌性の感染症コントロール法開発につながる可能性を有しており、臨床応用を含めた今後一定の波及効果が期待される。
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