2011 Fiscal Year Final Research Report
Elucidation of biological basis of autism as fatty acid metabolic disease
| Project/Area Number |
21200014
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
Metabolomics
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| Research Institution | Hamamatsu University School of Medicine (2010-2011)
Osaka University (2009) |
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Principal Investigator |
MATSUZAKI Hideo 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00334970)
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| Co-Investigator(Kenkyū-buntansha) |
ZAIMA Nobuhiro 近畿大学, 農学部, 講師 (40455572)
IWATA Keiko 浜松医科大学, 子どものこころの発達研究センター, 助教 (30415088)
OGAWA Mikako 浜松医科大学, メディカルフォトニクス研究センター, 准教授 (20344351)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJII Masatsugu 中京大学, 現代社会学部, 教授 (20257546)
SETOU Mitsutoshi 浜松医科大学, 医学部, 教授 (20302664)
TSUCHIYA Kenji 浜松医科大学, 子どものこころの発達研究センター, 准教授 (20362189)
ITOH Hiroaki 浜松医科大学, 周産母子センター, 教授 (70263085)
MAGATA Yasuhiro 浜松医科大学, メディカルフォトニクス研究センター, 教授 (20209399)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 自閉症 / 脂質代謝異常 / 発達 |
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| Research Abstract |
In this project, we were focusing on impaired Very Low Density Lipoprotein (VLDL) lipid fraction in serum of individuals with autism. Then, we examined the serum levels of fatty acid composition, autistic animal models based on the lipid profile, imaging analyze and a novel therapy method of autism by using the autistic animal model. To identify causal fatty acid of VLDL-specific lipid profile in autism, we analyzed fatty acid composition by GC-MS, which resulted in impairment of some fatty acids including omega-6. Next, we identified that CD38KO mice showed impairment of VLDL fraction and omega-6 fatty acid like autistic human subject, and found that feeding challenge of omega-6 fatty acid could rescue impairment of social recognition behavior in CD38KO mice immediately after birth. In VLDL Receptor transgenic rat (VLDLR-Tg), we examined behavior test and found that the rat showed hyperactivity and an entire impairment of arachidonic acid distribution in tissues of VLDLR-Tg.
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