2011 Fiscal Year Final Research Report
The new radiotherapy methods reoxiganated of intratumoral hypoxia induced by electrical stimulation
| Project/Area Number |
21200021
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKATA Eiko 東北大学, 大学院・医学系研究科, 非常勤講師 (60375201)
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| Co-Investigator(Kenkyū-buntansha) |
ARIGA Hisanori 岩手医科大学, 大学院・医学系研究科, 教授 (30333818)
HANDA Yasunobu 東北大学, 大学院・医学系研究科, 名誉教授 (00111790)
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| Co-Investigator(Renkei-kenkyūsha) |
OGURA Takahide 東北大学, 大学院・医学系研究科, 助教 (10312688)
SEKI Kazunori 東北大学, 大学院・医学系研究科, 非常勤講 (20206618)
TAKAI Yoshihiro 弘前大学, 大学院・医学系研究科, 教授 (50107653)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / 電気刺激 / 血流制御 / 低酸素領域 / 放射線治療 |
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| Research Abstract |
The hypoxic region in the tumor tissue resist for radiation. In this study, we tried the in vivo studies and investigated whether the blood flow and hypoxia in the tumor tissues are improved by the surface electrical stimulation.
We transplanted SCC-VII tumor to the C3H/HeJ female mice's right distal of femoral region and gave electrical stimulation at the sacral surface area from S2 to S4.
Therefore, blood flow at the surface of tumor was increased 22% during electrical stimulation and intratumor PO2 was increased 28% after 50 minutes from the end of electrical stimulation. The result of the microscopy of the tumor cells stained by hypoxic marker, the number of hypoxic cells of tumor was decreased 20% after 40 minutes from the end of electrical stimulation. The treatment results of radiotherapy combined with electrical stimulation is more better than independent radiotherapy.
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