2013 Fiscal Year Final Research Report
Magnetic Resonance Molecular Microimaging
| Project/Area Number |
21220007
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIZAWA Masatoyo 新潟大学, 脳研究所, 教授 (80198457)
FUJII Yukihiko 新潟大学, 脳研究所, 教授 (40283014)
IGARASHI Hironaka 新潟大学, 脳研究所, 教授 (20231128)
HUBER Vincent 新潟大学, 脳研究所, 准教授 (40422620)
TSUJITA Mika 新潟大学, 脳研究所, 准教授 (60397180)
SUZUKI Kiyotaka 新潟大学, 脳研究所, 准教授 (40303169)
KAKITA Akiyoshi 新潟大学, 脳研究所, 教授 (80281012)
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| Project Period (FY) |
2009-05-11 – 2014-03-31
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| Keywords | MRI / 7テスラ / MR microscopy / 解剖学的解像度 / 超高磁場 / MR spectroscopy / hyperpolarization / 機能画像 |
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| Research Abstract |
The research project was one of the most ambitious proposals aiming to develop ligand based MRI molecular imaging, a goal that has eluded world scientists for more than 30 years. Our research team successfully developed such a "dream" imaging method as we promised. The technique utilized O17, a stable isotope of oxygen, labeled specific ligand and its JJ vicinal coupling to its covalent proton. The method was termed JJ Vicinal Coupling Proton Exchange (JJVCPE) imaging by the project director. We applied this method to study water molecule dynamics utilizing H2O17, and beta-amyloid imaging utilizing O17-PiB in vivo. The studies showed that aquaporin-4 (AQP-4), abundant in glia in brain, plays a major role in the interstitional flow through the Virchow-Robin space. The disturbance in this system, which is critical for beta-amyloid clearance, plays a major role in the pathogentesis of Alzheimer disease.
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