A Twin Study on Sociability and Mental Health : A Bridge between Genes and Brain Activities

2011 Fiscal Year Final Research Report

• Project/Area Number: 21223002
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Educational psychology
• Research Institution: Keio University
• Principal Investigator: ANDO Juko 慶應義塾大学, 文学部, 教授 (30193105)
• Co-Investigator(Kenkyū-buntansha): TODA Toda 神戸大学, 大学院・医学研究科, 教授 (30262025)
• Co-Investigator(Renkei-kenkyūsha): KAWAI Yasuyo (MINAGAWA Yasuyo) 慶應義塾大学, 大学院・社会学研究科 (90521732) ; FUJISAWA Keiko 慶應義塾大学, 文学部, 助教 (00453530) ; ONO Yutaka 国立精神・神経医療研究センター, 認知行動療法センター, 所長 (70138098) ; HIRAISHI Kai 京都大学, こころの未来研究センター, 助教 (50343108)
• Project Period (FY): 2009 – 2011
• Keywords: 行動遺伝学 / 双生児法 / 児童期 / 青年期 / 認知能力 / 社会性 / 言語能力 / 脳機能

Research Abstract

The purpose of this research project is to clarify genetic and environmental influences on developmental processes of sociability and mental health conditions by two independent twin cohorts, one for childhood and the other for adolescence and adulthood, in a longitudinal way. The results revealed that development of cognitive abilities, problem behaviors and mental health conditions were influenced by genetic changes as well as various kinds of interaction between genes and family/cultural environment. Scientific foundations to identify genes and their expression and to clarify brain structure and functions related to cognitive functions were established.

Research Products

• [Journal Article] Hyperactivity/inattention problems moderate environmental but not genetic mediation between negative parenting and conduct problems (2012)
  • Author(s): Fujisawa, K. K., Yamagata, S., Ozaki, K. & Ando, J
  • Journal Title: Journal of Abnormal Child Psychology Volume: 40(2) Pages: 189-200
  • Peer Reviewed
• [Journal Article] The genetic and environmental relationships between head circumference growth in the first year of life and sociocognitive development in the second year : A longitudinal twin study (2012)
  • Author(s): Fujisawa, K., Ozaki, K., Suzuki, K., Yamagata, Y., Kawahashi, I. & Ando, J
  • Journal Title: Developmental Science Volume: 15(1) Pages: 99-112
  • Peer Reviewed
• [Journal Article] Genetic and environmental sex differences in mental rotation ability : A Japanese twin study (2012)
  • Author(s): Suzuki, K., Shikishima, C. & Ando, J
  • Journal Title: Twin Research and Human Genetics Volume: 14(5) Pages: 437-443
  • Peer Reviewed
• [Journal Article] Grayの行動抑制系と不安・抑うつ-双生児法による4つの因果モデルの検討 (2012)
  • Author(s): 山形伸二・高橋雄介・木島伸彦・大野裕・安藤寿康
  • Journal Title: パーソナリティ研究 Volume: 20 Pages: 110-117
  • Peer Reviewed
• [Journal Article] Functional hemispheric speciali-zation in processing phonemic and prosodic auditory changes in neonates (2011)
  • Author(s): Arimitsu, T., Uchida-Ota, M., Yagihashi, T., Kojima, S., Watanabe, S., Hokuto, I., Ikeda, K., Takahashi, T., Minagawa-Kawai, Y
  • Journal Title: Frontiers in Psychology Volume: 2 Pages: 202
  • Peer Reviewed
• [Journal Article] 共感性形成要因の検討-遺伝-環境交互作用モデルを用いて- (2011)
  • Author(s): 敷島千鶴・平石界・山形伸二・安藤寿康
  • Journal Title: 社会心理学研究 Volume: 26(3) Pages: 188-201
  • Peer Reviewed
• [Presentation] Genetic stability and change of cognitive abilities in adulthood : A 7-year longitudinal study (2011)
  • Author(s): Ando, J & Shikishima, C
  • Organizer: The 41st Annual Meeting of the Behavior Genetics Association
  • Place of Presentation: Newport, USA
  • Year and Date: 20110606-09
• [Presentation] Genome-Wide DNA Methylation and Gene Expression Analyses of Monozygotic Twins Discordant for Intelligence Levels (2011)
  • Author(s): Yu, CC., Furukawa, M., Kobayashi, K., Shikishima, C. Cha, PC., Sese, J., Sugawara, H., Iwamoto, K., Kato, T., Ando, J & Toda, T
  • Organizer: 日本人類遺伝学会第56回大会
  • Place of Presentation: 千葉(幕張メッセ)
  • Year and Date: 2011-11-12
• [Presentation] The Effect of Sibling Relationship on Individual Adjustment in Japanese Twin Children Compared with Singletons (2011)
  • Author(s): Nozaki, M., Fujisawa, K. K., Ando, J., & Hasegawa, T
  • Organizer: The 15th European Conference on Developmental Psychology
  • Place of Presentation: Bergen, Norway
  • Year and Date: 2011-08-26
• [Presentation] 3, 4歳児における言語処理に関連する神経活動の個人差-双生児法を用いて- (2010)
  • Author(s): 鈴木国威・安藤寿康
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪大学
  • Year and Date: 2010-09-21
• [Presentation] Genetic analysis of monozygotic twins discordant for cognitive abilities (2009)
  • Author(s): Kobayashi, K., Furukawa, M., Yu, C.-C., Shikishima, C., Ando, J., & Toda, T
  • Organizer: American Society of Human Genetics 59th Annual Meeting
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2009-10-22
• [Book] 遺伝子の不都合な真実-すべての能力は遺伝である (2012)
  • Author(s): 安藤寿康
  • Total Pages: 240
  • Publisher: 筑摩書房
• [Book] 遺伝マインド-遺伝子が織り成す行動と文化 (2011)
  • Author(s): 安藤寿康
  • Total Pages: 220
  • Publisher: 有斐閣
• [Remarks]
  • URL: http://totcop.keio.ac.jp/
• [Remarks]
  • URL: http://kts.keio.ac.jp/
• [Remarks] 報道関係(1)ナショナルジオグラフィック日本版「研究室へ行ってみた」で安藤のインタビュー記事が連載される。
  • URL: http://nationalgeographic.jp/nng/article/20120117/296498/
• [Remarks] (2) 2011年6月27日朝日新聞朝刊に「能力と性格の遺伝子検査」に対する安藤の批判コメントが掲載される
• [Remarks] (3) 2011年6月27日朝日新聞朝刊に「能力と性格の遺伝子検査」に対する安藤の批判コメントが掲載される。
• [Remarks] (4) 2010年4月13日NHK総合「爆笑問題のニッポンの教養～双子だけの秘密」に安藤が出演し双生児研究を紹介する。
• [Remarks] (5)ニュートン別冊(ニュートンムック)「知りたい!遺伝のしくみ」(2010年1月)に安藤の論文とデータが掲載される
• [Remarks] (6)(株)創元社から成果をシリーズとして書籍化する計画が進行中