2011 Fiscal Year Final Research Report
Analysis of Cell Invasion System and In Vivo Stealth Activityof Bio-nanocapsules
| Project/Area Number |
21240052
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nagoya University |
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Principal Investigator |
KURODA Shunichi 名古屋大学, 大学院・生命農学研究科, 教授 (60263406)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ナノメディシン / DDS / ナノキャリア / ウイルス |
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| Research Abstract |
We previously developed a hepatitis B virus (HBV) surface antigen L protein particle [bio-nanocapsule (BNC)] as a nonviral DDS nanocarrier. Intravenously injected BNCs were shown to avoid clearance by RES (reticuloendothelial system)-rich organs and accumulate in target tissues. In this study, since the surface modification with albumins is known to prolong the circulating half-life of nanomedicines, we demonstrated that the polymerized albumin receptor (PAR) of BNCs contributes to RES evasion in mouse liver,strongly suggesting that BNCs, as well as HBV, harbor an innate RES evasion mechanism. Therefore, the surface modification with PAR peptides could be an alternative strategy forimproving pharmacodynamics and pharmacokinetics of forthcoming nanomedicines.
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[Journal Article] Engineered bio-nanocapsules, hepatitis B virus surface antigen L protein particles, for in vivo active targeting to splenic dendritic cells2012
Author(s)
Matsuo, M., Yoshimoto, N., Iijima, M., Niimi, T., Jung, J., Jeong, S. Y., Choi, E. K., Sewaki, T., Arakawa, T., and Kuroda, S
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Journal Title
Int. J. Nanomed.
Volume: 7
Pages: 3341-3350
Peer Reviewed
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[Journal Article] Targeting of Polyplex to Human Hepatic Cells by Bio-nanocapsules, Hepatitis B Virus Surface Antigen L Protein Particles2012
Author(s)
Somiya, M., Yoshimoto, N., Iijima, M., Niimi, T., Dewa, T., Jung, J., and Kuroda, S
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Journal Title
Bioorg. Med. Chem.
Volume: 20
Pages: 3872-3879
Peer Reviewed
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[Journal Article] Hepatitis B Virus Envelope L Protein-Derived Bio-Nanocapsules: Mechanisms of Cellular Attachment and Entry into Human Hepatic Cells2012
Author(s)
Yamada, M., Oeda A., Jung J.H., Iijima M., Yoshimoto, N., Niimi, T., Jeong, S.Y., Choi, E.K., Tanizawa, K., and Kuroda, S
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Journal Title
J. Controlled Release
Volume: 160
Pages: 322-329
Peer Reviewed
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[Journal Article] Efficient and rapid purification of drugand gene-carrying bio-nanocapsules, hepatitis B virus surface antigen L particles, from Saccharomyces cerevisiae2011
Author(s)
Jung J., Iijima M., Yoshimoto N., Sasaki M., Niimi T., Tatematsu K., Jeong S.Y., Choi E.K., Tanizawa K., and Kuroda S
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Journal Title
Protein Exp. Purif
Volume: 78
Pages: 149-155
Peer Reviewed
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[Journal Article] Nanocapsules Incorporating IgG Fc-binding Domain Derived from Staphylococcus aureus Protein-A for Displaying IgGs on Immunosensor Chips2011
Author(s)
Iijima M, Kadoya H, Matsuzaki T, Hatahira S, Hiramatsu S, Jung G, Martin A, Quinn J, Jung J, Jeong SY, Choi EK, Arakawa T, Hinako F, Kusunoki M, Yoshimoto N, Niimi T, Tanizawa K, and Kuroda S
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Journal Title
Biomaterials
Volume: 32
Pages: 1455-1464
Peer Reviewed
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[Journal Article] Hepatoma-targeted gene delivery using a tumor cell-specific gene regulation system combined with a human liver cell-specific bionanocapsule2010
Author(s)
Kang JH, Oishi J, Kim JH, Ijuin M, Toita R, Jun B, Asai D, Mori T, Niidome T, Tanizawa K, Kuroda S, and Katayama Y
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Journal Title
Nanomedicine
Volume: 6
Pages: 583-589
Peer Reviewed
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[Journal Article] Bio-nanocapsule-liposome conjugates for in vivo pinpoint drugs and gene delivery2009
Author(s)
Kasuya, T., Jung, J., Kinoshita, R., Goh, Y., Matsuzaki, T., Iijima, M., Yoshimoto, N., Tanizawa, K., and Kuroda, S
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Journal Title
Methods in Enzymology
Volume: 464
Pages: 147-166
Peer Reviewed
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