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2012 Fiscal Year Final Research Report

Nuclear receptors as therapeutic targets for diabeticnephropathy.

Research Project

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Project/Area Number 21249053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionOkayama University

Principal Investigator

MAKINO Hirofumi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (50165685)

Co-Investigator(Kenkyū-buntansha) WADA Jun  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (30294408)
Co-Investigator(Renkei-kenkyūsha) OGAWA Daisuke  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70535195)
Project Period (FY) 2009 – 2012
Keywords核内受容体 / 糖尿病性腎症 / レチノイド / 細胞周期 / 糸球体上皮細胞 / PPAR / RXR / LXR
Research Abstract

In the development of diabetic nephropathy, the hypertrophy of renal cells is important for the initial disease process and chronic inflammation further promotes the progression of the disease. Modulator for nuclear receptors may improve these pathological processes. Peroxisome proliferator-activated receptor (PPAR)-δand Liver X receptor (LXR) agonists exerted therapeutic potential by improving inflammation. Retinoid X receptor (RXR) antagonist demonstrated therapeutic potential by correcting cell-cycle abnormalities and cellular hypertrophy. Modulators for nuclear receptors are beneficial for the treatment of diabetic nephropathy.

  • Research Products

    (24 results)

All 2013 2012 2011 2010 2009

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (4 results)

  • [Journal Article] Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease2013

    • Author(s)
      Kurose Y, Wada J, Kanzaki M, Teshigawara S, Nakatsuka A, Murakami K, Inoue K, Terami T, Katayama A, Watanabe M,Higushi C, Eguchi J, Miyatake N, Makino H
    • Journal Title

      BMC Nephrol

      Volume: 14 Pages: 23

    • Peer Reviewed
  • [Journal Article] Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex2013

    • Author(s)
      Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Ogawa D, Matsuki Y, Hiramatsu R, Tagita H, Kakuta S, Iwakura Y, Makino H
    • Journal Title

      Circ Res

      Volume: 112(5) Pages: 771-780

    • Peer Reviewed
  • [Journal Article] Telmisartan attenuates diabetic nephropathy by suppressing ixidative stress in db/db mice2013

    • Author(s)
      Sato-Horiguchi C, Ogawa D, Wada J, Tachibana H, Kodera R, Eguchi J, Nakatsuka A, Terami N, Shikata K, Makino H
    • Journal Title

      Nephron Exp Nephrol

      Volume: 121(3-4) Pages: e97-e108

    • Peer Reviewed
  • [Journal Article] The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO)2013

    • Author(s)
      Murakami K, Wada J, Ogawa D, Horiguchi CS, Miyoshi T, Sasaki M, Uchida HA, Nakamura Y, Makino H
    • Journal Title

      Diab Vasc Dis Res

      Volume: 10(1) Pages: 93-96

    • Peer Reviewed
  • [Journal Article] The serum vaspin levels are reduced in Japanese chronic hemodialysis patients.2012

    • Author(s)
      Inoue J, Wada J, Teshigawara S, Hida K, Nakatsuka A, Takatori U, Kojo S, Akagi S, Nakao K, Miyatake N, McDonald JF, Makino H
    • Journal Title

      BMC Nephrol

      Volume: 13(1) Pages: 163

    • Peer Reviewed
  • [Journal Article] Activation of liver x receptor inhibits osteopontin and ameliorates diabetic nephropathy2012

    • Author(s)
      Tachibana H, Ogawa D, Matsushita Y,Bruemmer D, Wada J, Teshigawara S, Eguchi J, Sato-Horiguchi C, Uchida HA, Shikata K, Makino H
    • Journal Title

      J Am Soc Nephrol

      Volume: 23(11) Pages: 1835-1846

    • Peer Reviewed
  • [Journal Article] Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex.2012

    • Author(s)
      Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H
    • Journal Title

      Diabetes

      Volume: 61(11) Pages: 2823-2832

    • Peer Reviewed
  • [Journal Article] The therapeutic potential of synthetic human atrial natriuretic peptide in nephrotic syndrome: a randomized controlled trial.2012

    • Author(s)
      Kanzaki M, Wada J, Kikumoto Y, Akagi S, Nakao K, Sugiyama H, Makino H
    • Journal Title

      Int J Nephrol Renovasc Dis

      Volume: 5 Pages: 91-96

    • Peer Reviewed
  • [Journal Article] Hydrogen-rich water prevents progression of non-alcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice.2012

    • Author(s)
      Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, Makino H, Yamamoto K
    • Journal Title

      Hepatology

      Volume: 56(3) Pages: 912-921

    • Peer Reviewed
  • [Journal Article] Serum vaspin concentrations are closely related to insulin resistance and rs77060950 at SERPINA12 genetically defines distinct group with higher serum levels in Japanese population.2012

    • Author(s)
      Teshigawara S, Wada J, Hida K, Nakatsuka A, Eguchi J, Murakami K, Kanzaki M, Inoe K, Terami T, Katayama A, Iseda I, Matsushita Y, Miyatake N, McDonald JF, Hotta K, Makino H
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 97(7) Pages: E1202-1207

    • Peer Reviewed
  • [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes2012

    • Author(s)
      Kanzaki M, Wada J, Sugiyama K, Nakatsuka A, Teshigawara S, Murakami K, Inoue K, Terami T, Katayama A, Eguchi J, Akiba H, Yagita H, Makino H
    • Journal Title

      Endocrinology

      Volume: 153(2) Pages: 612-620

    • Peer Reviewed
  • [Journal Article] Impact of circulating vaspin levels on metabolic variables in elderly twins2012

    • Author(s)
      Hida K, Poulsen P, Teshigawara S, Nilsson E, Friedrichsen M, Ribel-Madsen R, Grunnet L, Lund SS, Wada J, Vaag A
    • Journal Title

      Diabetologia

      Volume: 55(2) Pages: 530-532

    • Peer Reviewed
  • [Journal Article] RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21^Cip1pathway in adipocytes.2012

    • Author(s)
      Nakatsuka A, Wada J, Hida K, Hida A, Eguchi J, Teshigawara S, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Ogawa D, Kagechika H, Makino H
    • Journal Title

      J Pathol

      Volume: 226(5) Pages: 784-795

    • Peer Reviewed
  • [Journal Article] High glucose increases metallothionein expression in renal proximal tubular epithelial cells.2011

    • Author(s)
      Ogawa D, Asanuma M, Miyazaki I, Tachibana H, Wada J, Sogawa N, Sugaya T, Kitamura S, Maeshima Y, Shikata K, Makino H
    • Journal Title

      Exp Diabetes Res

      Volume: 2011 Pages: 534872

    • Peer Reviewed
  • [Journal Article] Icodextrin increases technique survival rate in peritoneal dialysis patients with diabetic nephropathy by improving body fluid management: a randomized controlled trial.2011

    • Author(s)
      Takatori Y, Akagi S, Sugiyama H, Inoue J, Kojo S, Morinaga H, Nakao K, Wada J, Makino H
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 6(6) Pages: 1337-1344

    • Peer Reviewed
  • [Journal Article] Activation of Peroxisome Proliferator-Activated Receptor δInhibits Streptozotocin-Induced Diabetic Nephropathy Through Anti-Inflammatory Mechanisms in Mice2011

    • Author(s)
      Matsushita Y, Ogawa D, Wada J, Yamamoto N, Shikata K, Sato C, Tachibana H, Toyota N, Makino H.
    • Journal Title

      Diabetes

      Volume: 60(3) Pages: 960-968

    • Peer Reviewed
  • [Journal Article] P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance2011

    • Author(s)
      Sato C, Shikata K, Hirota D, Sasaki M, Nishishita S, Miyamoto S, Kodera R, Ogawa D, Tone A, Kataoka HU, Wada J, Kajitani N, Makino H
    • Journal Title

      Diabetes

      Volume: 60(1) Pages: 189-99

    • Peer Reviewed
  • [Journal Article] In vivo delivery of gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7.2010

    • Author(s)
      Zhang Q, Shi Y, Wada J, Malakauskas SM, Liu M, Ren Y, Du C, Duan H, Li Y, Li Y, Zhang Y
    • Journal Title

      PLoS ONE

      Volume: 5(7) Pages: e11709

    • Peer Reviewed
  • [Journal Article] Effects of icodextrin peritoneal dialysis solution on the peritoneal membrane in the STZ-induced diabetic rat model with partial nephrectomy2010

    • Author(s)
      Nakao A, Nakao K, Takatori Y, Kojo S, Inoue J, Akagi S, Sugiyama H, Wada J, Makino H
    • Journal Title

      Nephrol Dial Transplant

      Volume: 25(5) Pages: 1479-1488

    • Peer Reviewed
  • [Journal Article] Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins.2009

    • Author(s)
      Sarai K, Shikata K, Shikata Y, Omori K, Watanabe N, Sasaki M, Nishishita S, Wada J, Goda N, Kataoka N, Makino H
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 297(4) Pages: C945-54

    • Peer Reviewed
  • [Presentation] Renin angiotensin system inhibition in diabetic nephropathy.2012

    • Author(s)
      Makino H:
    • Organizer
      ASN Kidney Week 2012
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2012-11-02
  • [Presentation] Basic mechanism underlying diabetic nephropathy and CKD.2011

    • Author(s)
      Makino H:
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2011-04-11
  • [Presentation] 全身を制御する腎臓-33年の腎臓研究を顧みて-2010

    • Author(s)
      槇野博史
    • Place of Presentation
      神戸市
    • Year and Date
      2010-06-17
  • [Presentation] Thiazolidinediones and diabetic nephropathy2009

    • Author(s)
      Makino H
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-22

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Published: 2014-08-29  

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