動体追跡医科学研究

2009 Fiscal Year Annual Research Report

• Project/Area Number: 21249065
• Research Institution: Hokkaido University
• Principal Investigator: 白土 博樹 Hokkaido University, 大学院・医学研究科, 教授 (20187537)
• Co-Investigator(Kenkyū-buntansha): 本間 さと 北海道大学, 大学院・医学研究科, 教授 (20142713) ; 玉木 長良 北海道大学, 大学院・医学研究科, 教授 (30171888) ; 芳賀 永 北海道大学, 大学院・理学研究科, 准教授 (00292045) ; 但野 茂 北海道大学, 大学院・工学研究科, 教授 (50175444) ; 石川 正純 北海道大学, 大学院・医学研究科, 准教授 (80314772)
• Keywords: 量子線シミュレーション / 電子線トラック解析 / モンテカルロ法 / 放射線治療 / プラスチック検出器 / 体幹部定位放射線照射 / 非線形最適化

Research Abstract

複数の動体として2-8個の金マーカーを同時にリアルタイムに追跡する画像処理システムを開発研究し、ヒト以外の動体であるマウスの画像でも追跡可能とするための基礎研究を行った。モンテカルロシミュレーションによるリニアックX線光子と、それによって発生する電子線のモンテカルロシミュレーションにより放射線ビームの生物効果を解析した。複数細胞の2次元での動体追跡を概念設計し、細胞の遊走能の定量化と遊走能関連遺伝子発現に関する検討を行った。放射線感受性の異なる細胞間で、3次元的な細胞遊走能に違いがあることが示され、動体追跡技術の応用方法のヒントを得た。覚醒マウスの動体追跡技術の研究を進め、ケージ内の動物の動きを光学的カメラで追跡する装置の設計と、そのin vivo遺伝子発現日内リズムの研究を進めた。
腫瘍の縮小・変形を6名の上咽頭癌患者の頸部リンパ節の照射中に毎週CTを行って検査し、その変化をfinite elementモデルと変形マップを用いて解析した。また、その縮小率に関して弾性体を模した腫瘍モデルを提案し、放射線治療計画において、腫瘍の縮小を的確に予測し、強度変調放射線治療の治療計画に利用することを検討した。放射線治療中の腫瘍縮小に及ぼす因子の研究として、生体の正常組織の状態・免疫状態の変化が腫瘍の縮小に及ぼす影響をマウスにて解析した。
放射線治療計画・効果判定を志向したPETプローブとして、臨床試験に利用するにはどのプローブが最適かを検討し、放射線治療中のPET撮像を可能にするための問題点として、低酸素細胞領域の時間的移動が示唆された。いままでの動体追跡照射の問題であった保留性を高めた新しい体内マーカーの開発研究を行った。動体追跡装置を利用した癌治療の長期的効果を解析し、他治療との比較検討を探索的に行った。

Research Products

• [Journal Article] Evaluation of the Effectiveness of the Stereotactic Body Frame in Reducing Respiratory Intrafractional Organ Motion using the Real-time Tumor-tracking Radiotherapy System. (2010)
  • Author(s): Bengua G, Ishikawa M, Sutherl, K, Horita K, Yamazaki R, Fujita K, Onimaru R, Katoh N, Inoue T, Onodera S, Shirato H.
  • Journal Title: Int J Radiat Oncol Biol Phys. (In press)
  • Peer Reviewed
• [Journal Article] Physical exercise accelerales re-entrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8h phase-advanced sleep schedule. (2010)
  • Author(s): Yamanaka, Y.
  • Journal Title: Am.J.Physiol.Regul.Integ.Comp.Physiol. (In press)
  • Peer Reviewed
• [Journal Article] A parameter study of pencil beam proton dose distributions for the treatment of ocular melanoma utilizing spot scanning (2010)
  • Author(s): K.Sutherland, S.Miyajima, H.Date, H.Shirato, M.Ishikawa, M.Murakami, M.Yamagiwa, P.Bolton, T.Tajima
  • Journal Title: Radiol.Phys.Technol. 3 Pages: 16-22
  • Peer Reviewed
• [Journal Article] Nuclear collision processes around the Bragg peak in proton therapy (2010)
  • Author(s): Y.Matsuzaki, H.Date, K.L.Sutherland, Y.Kiyanagi
  • Journal Title: Radiol.Phys.Technol. 3 Pages: 84-92
  • Peer Reviewed
• [Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : Its potentiation by combination with Th1 cell therapy (2010)
  • Author(s): Takeshima T, Chamoto K, et al.
  • Journal Title: Cancer Research (In press)
  • Peer Reviewed
• [Journal Article] 3-Methylcholanthrene-induced transforming growth factor-beta-producing carcinomas, but not sarcomas, are refractory to regulatory T cell-depletion therapy. (2010)
  • Author(s): Chamoto K, et al.
  • Journal Title: Cancer Science (In press)
  • Peer Reviewed
• [Journal Article] The development and clinical use of a beam ON-LINE PET system mounted on a rotating gantry port in proton therapy (2010)
  • Author(s): Teiji, Nishio, et al.
  • Journal Title: Int.J.Radiat.Oncol.BiolPhys. 76(1) Pages: 277-286
  • Peer Reviewed
• [Journal Article] Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. 2010 (2010)
  • Author(s): Kuge Y, et al.
  • Journal Title: Springer Science+Business Media, Heidelberger(Tamaki N, Kuge Y eds.)(Springer) Pages: 19-29/303
• [Journal Article] Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinom a cells. 93 (2009)
  • Author(s): Chamoto K, Takeshima T, Wakita D, Ohkuri T, Ashino S, Omatsu T, Shirato H, Kitamura H, Togashi Y, Nishimura T.
  • Journal Title: Cancer Sci. 100(5) Pages: 934-939
  • Peer Reviewed
• [Journal Article] A feasibility study of novel plastic scintillation dosimetry with pulse-counting mode. (2009)
  • Author(s): Ishikawa M, Bengua G, Sutherl, KL, Hiratsuka J, Katoh N, Shimizu S, Aoyama H, Fujita K, Yamazaki R, Horita K, Shirato H.
  • Journal Title: Phys Med Biol. 54(7) Pages: 2079-2092
  • Peer Reviewed
• [Journal Article] Radiation pneumonitis in patients treated for malignant pulmonary lesions with hypofractionated radiation therapy. (2009)
  • Author(s): Borst GR, Ishikawa M, Nijkamp J, Hauptmann M, Shirato H, Onimaru R, van den Heuvel MM, Belderbos J, Lebesque JV, Sonke JJ.
  • Journal Title: Radiother Oncol. 91(3) Pages: 307-313
  • Peer Reviewed
• [Journal Article] Value of fluorodeoxyglucose positron emission tomography before radiotherapy for head and neck cancer : does the standardized uptake value predict treatment outcome? (2009)
  • Author(s): Suzuki K, Nishioka T, Homma A, Tsuchiya K, Yasuda M, Aoyama H, Onimaru R, Tamaki N, Shirato H.
  • Journal Title: Jpn J Radiol. 27(6) Pages: 237-242
  • Peer Reviewed
• [Journal Article] Can hybrid FDG-PET/CT detect subclinical lymph node metastasis of esophageal cancer appropriately and contribute to radiation treatment planning? A comparison of image-based and pathological findings. (2009)
  • Author(s): Shimizu S, Hosokawa M, Itoh K, Fujita M, Takahashi H, Shirato H.
  • Journal Title: Int J Clin Oncol. 14(5) Pages: 421-425
  • Peer Reviewed
• [Journal Article] The liver X receptors(LXRα and LXRβ)are potent regulators for hepatic Decl expression (2009)
  • Author(s): Noshiro, M, et al.
  • Journal Title: Genes to Cells 14 Pages: 29-40
  • Peer Reviewed
• [Journal Article] Self-sustained circadian rhythm in cultured human mononuclear cells isolated from peripheral blood. (2009)
  • Author(s): Ebisawa, S., et al.
  • Journal Title: Neurosci Res. 66 Pages: 223-227
  • Peer Reviewed
• [Journal Article] The SCN-independent clocks, methamphetamine and food restriction. (2009)
  • Author(s): Honma, K.
  • Journal Title: Eur.J.Neurosci 30 Pages: 1707-1717
  • Peer Reviewed
• [Journal Article] 睡眠障害の時間治療 (2009)
  • Author(s): 山仲勇二郎
  • Journal Title: 医療ジャーナル 145 Pages: 107-112
• [Journal Article] Synthesis and evaluation of a radioiodinated Lumiracoxib derivative for the imaging of cyclooxygenase-2 expression. (2009)
  • Author(s): Kuge Y, et al.
  • Journal Title: Nucl Med Biol. 36(8) Pages: 869-876
  • Peer Reviewed
• [Journal Article] A New PET Scanner with semiconductor detectors enables better indentifcation of intratumoral ihomogeneity (2009)
  • Author(s): Shiga T, Morimoto Y, Kubo N, Katoh N, Katoh C, Takeuchi W, Usui R, Hirata, K, Kojima S, Umegaki K, Shirato H, Tamaki N
  • Journal Title: J Nucl Med 50(1) Pages: 148-155
  • Peer Reviewed
• [Journal Article] Radioiodine therapy for thyroid cancer depicted uterine leiomyoma (2009)
  • Author(s): Hirata K, Shiga T, Kubota K, Okamoto S, Kamibayashi T, Tamaki N
  • Journal Title: Clin Nucl Med 34(3) Pages: 180-181
  • Peer Reviewed
• [Journal Article] Clinical value and limitations of 11C-methionine PET for detection and localization of suspected parathyroid adenomas (2009)
  • Author(s): Hermann K, Takei T, Kanegae K, Shiga T, Buck AK, Altomonte J, Schwaiger M, Schuster T, Nishijima K, Kuge Y, Tamaki N
  • Journal Title: Mol Imaging Biol 11(5) Pages: 356-363
  • Peer Reviewed
• [Journal Article] ランダム関数の関数主要点と関数クラスタリングについて (2009)
  • Author(s): 清水信夫, 水田正弘
  • Journal Title: 計算機統計学 21 Pages: 1-13
  • Peer Reviewed
• [Journal Article] 相対射影追跡法の関数データへの拡張 (2009)
  • Author(s): 弘新太郎, 南弘征, 水田正弘
  • Journal Title: 計算機統計学 21 Pages: 15-28
  • Peer Reviewed
• [Journal Article] Nanometer site analysis of electron tracks and dose localization in bio-cells exposed to X-ray irradiation (2009)
  • Author(s): H.Date, Y.Yoshii, K.L. Sutherl
  • Journal Title: Nucl.Instr.and Meth.B. 267 Pages: 1135-1138
  • Peer Reviewed
• [Journal Article] Time-of-flight observation of electron swarm in methane (2009)
  • Author(s): H.Hasegawa, H.Date, K.Yoshida, M.Shimozuma
  • Journal Title: Journal of Applied Physics. 105 Pages: 113308(1-6)
  • Peer Reviewed
• [Journal Article] Long-term outcome after endoscopic resection in patients with hypopharyngeal carcinoma invading the subepithelium : a case series. (2009)
  • Author(s): Shimizu Y, Yoshida T, Kato M, Ono S, Nakagawa M, Homma A, Oridate N, Asaka M.
  • Journal Title: Endoscopy 41 Pages: 374-376
  • Peer Reviewed
• [Journal Article] Effects of preoperative administration of omeprazole on bleeding after endoscopic submucosal dissection : a prospective randomized controlled trial (2009)
  • Author(s): Ono S, Kato M, Ono Y, Nakagawa M, Nakagawa S, Shimizu Y, Asaka M.
  • Journal Title: Endoscopy 41 Pages: 299-303
  • Peer Reviewed
• [Journal Article] Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD : the first multicenter trial in Japan (2009)
  • Author(s): Ozawa S, Kumai K, Higuchi K, Arakawa T, Kato M, Asaka M, Katada N, Kuwano H, Kitajima M.
  • Journal Title: J Gastroenterol 44 Pages: 675-684
  • Peer Reviewed
• [Journal Article] Preliminary trial of rebamipide for prevention of low-dose aspirin-induced gastric injury in healthy subjects : A randomized double-blind, Placebo-controlled, cross-over study (2009)
  • Author(s): Ono S, Kato M, Imai A, Yoshida T, Hirota J, Hata T, Takagi K, Kamada G, Ono Y, Nakagawa M, Nakagawa S, Shimizu Y, Takeda H, Asaka M.
  • Journal Title: J Clin Biochem Nutr 45 Pages: 248-253
  • Peer Reviewed
• [Journal Article] Metachronous gastric cancer following complete remission of gastric MALT lymphoma (2009)
  • Author(s): Ono S, Kato M, Takagi K, Kodaira J, Kubota K, Matsuno Y, Komatsu Y, Asaka M
  • Journal Title: Ann Oncol 20 Pages: 1748-1749
  • Peer Reviewed
• [Journal Article] Successful salvage endoscopic mucosal resection for residual superficial hypopharyngeal carcinoma after chemoradiotherapy, with long-term survival (2009)
  • Author(s): Yoshida T, Shimizu Y, Ono S, Oridate N, Kato M, Asaka M.
  • Journal Title: Endoscopy 41 Pages: 568-569
  • Peer Reviewed
• [Journal Article] Immediate acid-suppressing effects of ranitidine hydrochloride and rabeprazole sodium following initial administration and reintroduction : A randomized, cross-over study using wireless pH monitoring capsules. (2009)
  • Author(s): Ono S, Kato M, Ono Y, Imai A, Yoshida T, Shimizu Y, Asaka M.
  • Journal Title: J Gastroenterol Hepatol 24 Pages: 639-645
  • Peer Reviewed
• [Journal Article] Investigation of Gastric and Duodenal Mucosal Defects Caused by Low-dose Aspirin in Patients with Ischemic Heart Disease (2009)
  • Author(s): Nema H, Kato M, Katsurada T, Nozaki Y, Yotsukura A, Yoshida I, Sato K, Kawai Y, Takagi Y, Okusa T, Takiguchi S, Sakurai M, Asaka M
  • Journal Title: J Clin Gastroenterol 43 Pages: 130-132
  • Peer Reviewed
• [Journal Article] IFN-g-dependent type 1 immunity is crucial for immunosurveillance against squamous cell carcinoma in a novel mouse carcinogenesis model. Carcinogenesis (2009)
  • Author(s): Wakita D, Chamoto K, et al.
  • Journal Title: Carcinogenesis 30 Pages: 1408
  • Peer Reviewed
• [Journal Article] 動体追跡照射における体内マーカ追跡用による皮膚吸収線量定シミュレーション (2009)
  • Author(s): 河窪正照
  • Journal Title: 日本放射線技術学会誌 65 Pages: 456-461
  • Peer Reviewed
• [Journal Article] Single infusion of Zoledronic acid to prevent androgen deprivation therapy-induced bone loss in men with hormone-naive prostate carcinoma (2009)
  • Author(s): Satoh T, Kimura M, Ishiyama H, Hayakawa K, Baba S, et al.
  • Journal Title: Cancer 115(15) Pages: 3468-3474
  • Peer Reviewed
• [Journal Article] Genitourinary toxicity after high-dose-rate(HDR)brachytherapy combined with Hypofractionated External beam radiotherapy for localized prostate cancer : an analysis to determine the correlation between dose-volume histogram parameters in HDR brachytherapy and severity of toxicity. (2009)
  • Author(s): Ishiyama H, Kitano M, Satoh T, Kotani S, Uemae M, Matsumoto K, Okusa H, Tahata K, Baba S, Hayakawa K.
  • Journal Title: Int J Radiat Oncol Biol Phys 75(1) Pages: 23-28
  • Peer Reviewed
• [Journal Article] Cost comparison of curative therapies for localized prostate cancer in Japan : a single-institution experience. (2009)
  • Author(s): Satoh T, Ishiyama H, Hayakawa K, Baba S, et al.
  • Journal Title: Jpn J Radiol. 27(9) Pages: 348-354
  • Peer Reviewed
• [Journal Article] Analysis of Three-Dimensional Characteristics in Tumor Morphology (2009)
  • Author(s): S.Takao, S.Tadano, H.Taguchi, H.Shirato
  • Journal Title: Journal of Biomechanical Science and Engineering 4 Pages: 221-229
  • Peer Reviewed
• [Journal Article] Computer Simulation of Radiotherapy for Malignant Tumor-A Mechanical Analogy Method (2009)
  • Author(s): S.Takao, S.Tadano, H.Taguchi, H.Shirato
  • Journal Title: Journal of Biomechanical Science and Engineering 4 Pages: 576-588
  • Peer Reviewed
• [Journal Article] Roles of the primate motor thalamus in the generation of anti-saccades
  • Author(s): Kunimatsu J, Tanaka M
  • Journal Title: Journal of Neuroscience (In press)
  • Peer Reviewed
• [Presentation] Basics of real-time tumor tracking radiothrepy(RTRT)and development of a next generation RTRT (2010)
  • Author(s): Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutberland, Bengua Gerard, Ryusuke Suzuki, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
  • Organizer: 5th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai, Excel Hotel Tokyu
  • Year and Date: 20100224-20100225
• [Presentation] 頭頸部リンパ節腫瘍の放射線治療効果予測におけるパラメータ同定 (2010)
  • Author(s): 高尾聖心, 但野茂, 田口大志, 白土博樹
  • Organizer: 日本機械学会第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山市、岡山理科大学
  • Year and Date: 2010-01-09
• [Presentation] 左胃動静脈瘻に対してTAEによる閉鎖を行った一例 (2009)
  • Author(s): 曽山武士、阿保大介、長谷川悠、作原祐介、西川昇、白土博樹、寺江聡、清水匡
  • Organizer: 第121回北日本地方会
  • Place of Presentation: 仙台市、艮稜会館
  • Year and Date: 20091106-20091107
• [Presentation] Transcatheter Arterial Embolization with Absolute Ethanol Injection for Enlarged Polycystic Kidneys : Early Clinical Experience (2009)
  • Author(s): Yusuke Sakuhara, Daisuke Abo, Yu Hasegawa, Tadashi Shimizu, MD, Hiroki Shirato, Satoshi Terae.
  • Organizer: RSNA
  • Place of Presentation: 仙台市、艮稜会館
  • Year and Date: 20091106-20091107
• [Presentation] Can the real-time tumor-tracking radiotherapy give the planned dose to the tumor? DVH analysis based on measured real-time tracking data (2009)
  • Author(s): Masayori Ishikawa, Kenneth Sutherland, Gerard Bengua, Ryusuke Suzuki, Naoki Miyamoto, Norio Katoh, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
  • Organizer: 51st Annual meeting of American Society of Therapeutic Radiology and Oncology
  • Place of Presentation: Chicago, McComick Place West Chicago
  • Year and Date: 20091101-20091105
• [Presentation] Detection of Patient Set-up Errors With a Portal Image-DRR Registration Software System (2009)
  • Author(s): Kenneth Sutherland, Masayori Ishikawa, Gerard Bengua, Yoichi Ito, Hiroki Shirato
  • Organizer: 51st Annual meeting of American Society of Ther apeutic Radiology and Oncology
  • Place of Presentation: Chicago, McComick Place West Chicago
  • Year and Date: 20091101-20091105
• [Presentation] RTRT-based evaluation of the systematic errors in 3D CRT patient set-up localization using skin or shell markers (2009)
  • Author(s): Gerard Bengua, Masayori Ishikawa, Kenji Horita, Shitaro Tsuji, Hiroki Shirato
  • Organizer: 9th Asia-Oceania Congress of Medical Physics and The Seventh South East Asia Congress of Medical Physics
  • Place of Presentation: Chienmai、The Empress Convention Center
  • Year and Date: 20091020-20091025
• [Presentation] Statistical properties of radiation damage to bio-cells by X-rays exposure (2009)
  • Author(s): H.Date, Y.Yoshii
  • Organizer: 8^<th> International Meeting on the Effects of Low Doses and Very Low Doses of Ionizing Radiation on HumanHealth and Biotopes
  • Place of Presentation: Windsor Hotel, Barra da Tijuca, Rio de Janeiro, Brazil
  • Year and Date: 20090928-20090930
• [Presentation] Evaluation of FMISO Uptake in Rat Tumor Tissue : Comparison with FDG Uptake (2009)
  • Author(s): Hatano T, et al.
  • Organizer: 2009 World Molecular Imaging Congress
  • Place of Presentation: Montrcal, Canada
  • Year and Date: 20090923-20090926
• [Presentation] 動体追跡装置を用いた肺定位照射時の投与線量解析-動体追跡データに基づくDVH解析- (2009)
  • Author(s): 石川正純、Kenneth Sutherland、宮本直樹、Gerard Bengua、清水伸一、青山英史、鬼丸力也、木村傑、白土博樹
  • Organizer: 日本放射線腫瘍学会第22回学術大会
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 20090917-20090919
• [Presentation] 動体追跡放射線治療におけるX線透視条件の最適化 (2009)
  • Author(s): 宮本直樹、石川正純、Kenneth Sutherland、Gerard Bengua、清水伸一、青山英史、鬼丸力也、木村傑、白土博樹
  • Organizer: 第98回日本医学物理学会
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 20090917-20090919
• [Presentation] 動体追跡装置におけるコントラスト-ノイズ比(CNR)の測定方法の検討 (2009)
  • Author(s): 木村傑、宮本直樹、石川正純、Kenneth Sutherland、Gerard Bengua、清水伸一、青山英史、鬼丸力也、白土博樹
  • Organizer: 第98回日本医学物理学会
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 20090917-20090919
• [Presentation] CT during arteriographyによる膵の血流分布領域の検討 (2009)
  • Author(s): 作原祐介、児玉芳尚、阿保大介、長谷川悠、清水匡、白土博樹、寺江聡
  • Organizer: 第38回 日本インターベンショナルラジオロジー学会総会
  • Place of Presentation: 大阪、ハイアット・リージェンシー・オーサカ
  • Year and Date: 20090805-20090807
• [Presentation] Stereotactic Body Radiutherapy for Peripheral Stage I Non-small Cell Lung Cancer : A single institution experience by respiratory gating and tumor-tracking methods. (2009)
  • Author(s): Hayakawa K, Kotani S, Niibe Y.Katagiri M, Mitsufuji H, Masuda N, et al.
  • Organizer: 13^<th> World Conference on Lung Cancer
  • Place of Presentation: San Francisco, USA, MOSCONE WEST
  • Year and Date: 20090731-20090804
• [Presentation] 3.0T MRIを用いた乳房MRI撮像法(Split Dynamic法)の検討 (2009)
  • Author(s): 加藤扶美, 尾松徳彦, 小野寺祐也, 神島保, 大山徳子, 寺江聡, 白土博樹, 高橋将人, 細田充主, 高橋弘昌, 水戸寿々子, 石坂欣也, 坂元哲郎, 勝又康友, Marc Van Cauteren
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: 東京都、ホテルグランパシフィック
  • Year and Date: 20090703-20090704
• [Presentation] POWER DOPPLER ULTRASOUND OF RHEUMATOID SYNOVITIS : QUANTIFICATION OF VASCULAR SIGNAL AND ANALYSIS OF INTER-OBSERVER VARIABILITY (2009)
  • Author(s): T.Kamishima, K.Tanimura, M.Henmi, A.Narita, F.Sakamoto, S.Terae, H.Shirato
  • Organizer: 欧州リウマチ学会
  • Place of Presentation: デンマーク、Bella Center
  • Year and Date: 20090609-20090612
• [Presentation] RHEUMATOID FINGER JOINT SYNOVTTIS : POWER DOPPLER US QUANTIFICATIONS FOLLOWING ANTI-TUMOR NECROSIS FACTOR ALPHA TREATMENT (2009)
  • Author(s): T.Kamishima, A.Sagawa, K.Tanimura, A.Shimizu, M.Matsuhashi, M.Shinohara, H.Hagiwara, M.Henmi, A.Narita, S.Terae, H.Shirato
  • Organizer: 欧州リウマチ学会
  • Place of Presentation: デンマーク、Bella Center
  • Year and Date: 20090609-20090612
• [Presentation] 3D-BASED SIMPLIFIED WRIST PANNUS VOLUME MEASUREMENT ON CONTRAST-ENHANCED AND NON-ENHANCED MRI IN RHEUM ATOID ARTHRITIS (2009)
  • Author(s): T.Kamishima, K.Tanimura, M.Shimizu, M.Matsuhashi, J.Fukae, Y.Kon, Y.Aoki, A.Kitano, S.Terae, H.Shirato
  • Organizer: 欧州リウマチ学会
  • Place of Presentation: デンマーク、Bella Center
  • Year and Date: 20090609-20090612
• [Presentation] ラット腫瘍組織におけるFMISO集積の評価:FDG集積との比較 (2009)
  • Author(s): 波多野利行, 他
  • Organizer: 第4回日本分子イメージング学会学術集会
  • Place of Presentation: 東京、学術総合センター
  • Year and Date: 20090514-20090515
• [Presentation] 陽子線治療におけるbeam on-line PET systemの臨床利用と有用性 (2009)
  • Author(s): 西尾禎治, 他
  • Organizer: 日本医学物理学会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 20090417-20090419
• [Presentation] 体内臓器同期照射を目的とした次世代動体追跡装置の開発～複数マーカ追跡への挑戦～ (2009)
  • Author(s): 石川正純、Kenneth Sutherland、宮本直樹、Gerard Bengua、清水伸一、青山英史、鬼丸力也、木村傑、白土博樹
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 20090417-20090419
• [Presentation] 体内臓器同期照射を目的とした次世代動体追跡装置の開発～透視画像の歪みと位置計算誤差～ (2009)
  • Author(s): 宮本直樹、石川正純、Kenneth Sutherland、Gerard Bengua、清水伸一、青山英史、鬼丸力也、木村傑、白土博樹
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 20090417-20090419
• [Presentation] 体内臓器同期照射を目的とした次世代動体追跡装置の開発～デジタル画像機器としての定量的評価～ (2009)
  • Author(s): 木村傑、石川正純、Kenneth Sutherland、宮本直樹、Gerard Bengua、鈴木隆介、清水伸一、青山英史、鬼丸力也、白土博樹
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 20090417-20090419
• [Presentation] 対向型PET装置を用いた患者位置確認システムの開発-GEANT4基礎シミュレーション- (2009)
  • Author(s): 山口哲、石川正純、棚邊哲史、Gerard Bengua、Kenneth Sutherland、宮本直樹、鈴木隆介、青山英史、武島嗣英、白土博樹
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 20090417-20090419
• [Presentation] 対向型PET装置を用いた分子イメージング動体追跡装置の開発～^<18>F点線源を用いた追跡精度の検証～ (2009)
  • Author(s): 棚邊哲史、石川正純、山口哲、武島嗣英、鈴木隆介、宮本直樹、加藤徳雄、清水伸一、鬼丸力也、白土博樹
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 20090417-20090419
• [Presentation] 定位放射線治療後の肝細胞癌および周囲組織の病理組織学的変化 (2009)
  • Author(s): 沖本智昭
  • Organizer: 山口県放射線科医会
  • Place of Presentation: 山口、山口グランドホテル
  • Year and Date: 2009-12-12
• [Presentation] Urokinase-type plasminogen activator overexpressed in cancer stem cell promote the immunosuppressive tumor escape via TGF-β-Treg axis (2009)
  • Author(s): 茶本健司, et al.
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪、大阪国際会議場
  • Year and Date: 2009-12-03
• [Presentation] Overview of other endoscopic situations(such as stomach and duodenum) (2009)
  • Author(s): Kato M
  • Organizer: GASTRO2009
  • Place of Presentation: London, Excel London
  • Year and Date: 2009-11-22
• [Presentation] Roles of the thalamus in voluntary eye movements (2009)
  • Author(s): Tanaka M
  • Organizer: International Symposium--New Perspectives on Neural Mechanisms of Cognition and Action
  • Place of Presentation: Tokyo、玉川大学脳科学研究所
  • Year and Date: 2009-11-13
• [Presentation] Thalamic roles in voluntary eye movements (2009)
  • Author(s): Tanaka M
  • Organizer: 第8回中国神経科学学会全国大会
  • Place of Presentation: 中国、広州華泰賓館
  • Year and Date: 2009-11-08
• [Presentation] 生体リズムのイメージング (2009)
  • Author(s): 本間さと
  • Organizer: 第62回日本自自律神経学会
  • Place of Presentation: 和歌山、ダイワロイネットホテル
  • Year and Date: 2009-11-06
• [Presentation] Seasonality in sleep and wakefulness. (2009)
  • Author(s): Honma, S.
  • Organizer: The 6^<th> Congress of Asian Sleep Research Society.
  • Place of Presentation: Osaka, Osaka Convention Center
  • Year and Date: 2009-10-26
• [Presentation] ホルモン分泌と生物時計機構:生物発光レポーターとその応用 (2009)
  • Author(s): 本間さと
  • Organizer: 第9回日本内分泌学会北海道地方会
  • Place of Presentation: 札幌、かでる2.7
  • Year and Date: 2009-10-10
• [Presentation] uPA overexpressed in cancer stem cell promote the immunosuppressive tumor escape via TGF-β-Treg axis (2009)
  • Author(s): Chamoto K, et al.
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] 時間情報処理の神経生理学的研究:視覚科学の学際的アプローチに向けて (2009)
  • Author(s): 田中真樹
  • Organizer: 東北大学共同プロジェクト講演会
  • Place of Presentation: 東北大学、電気通信研究所
  • Year and Date: 2009-09-30
• [Presentation] Time trend changes of H.pylori infection and gastric cancer in Asian-Pacific region (2009)
  • Author(s): Kato M
  • Organizer: Asian Pacific Digestive Week 2009
  • Place of Presentation: Taipei, Taipei International Convention Center
  • Year and Date: 2009-09-29
• [Presentation] Entrainment of neuronal activity to periodic stimuli in the primate deep cerebellar nuclei(サル小脳核ニューロンにみられた引き込み現象) (2009)
  • Author(s): Tanaka M, Ohmae S, Uematsu A
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋、名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] Evaluation of Therapeutic Response to Radiotherapy Based on Tumor Geometry (2009)
  • Author(s): S.Takao, S.Tadano, H.Taguchi, H.Shirato
  • Organizer: IV International Conference on Computational Bioengineering
  • Place of Presentation: Bertinoro Conference Centre, Bcrtinoro, Italy
  • Year and Date: 2009-09-17
• [Presentation] Subcortical control of behavioral timing (2009)
  • Author(s): Tanaka M
  • Organizer: Basal Ganglia : Health and Disease(Satellite Symposium of the 32^<nd> Annual Meeting of the Japan Neuroscience Society)
  • Place of Presentation: Okazaki,岡崎カンファレンスセンター
  • Year and Date: 2009-09-15
• [Presentation] サル前頭前野における空間的注意のトップダウン制御 (2009)
  • Author(s): 松嶋藻乃、田中真樹
  • Organizer: 第89回日本生理学会北海道地方会
  • Place of Presentation: 札幌、北海道大学
  • Year and Date: 2009-09-12
• [Presentation] 欠落oddball課題における2種類の検出メカニズム (2009)
  • Author(s): 大前彰吾、植松明子、田中真樹
  • Organizer: 第89回日本生理学会北海道地方会
  • Place of Presentation: 札幌、北海道大学
  • Year and Date: 2009-09-12
• [Presentation] サル前頭葉内側部の微小電気刺激が運動タイミングに及ぼす影響 (2009)
  • Author(s): 國松淳、田中真樹
  • Organizer: 第89回日本生理学会北海道地方会
  • Place of Presentation: 札幌、北海道大学
  • Year and Date: 2009-09-12
• [Presentation] 生存戦略としての生物時計-その分子・細胞メカニズム (2009)
  • Author(s): 本間さと
  • Organizer: 第4回体温調節・温度受容研究会
  • Place of Presentation: 岡崎、岡崎カンファレンスセンター
  • Year and Date: 2009-09-11
• [Presentation] Non-photic time cues and animal life : photic cue is not almighty Symposium on"Entrainment by non-photic time cues (2009)
  • Author(s): Honma, S.
  • Organizer: IX th European Congress on Biological Rhythms
  • Place of Presentation: France, University of Strasbourg, Sttasboug
  • Year and Date: 2009-08-24
• [Presentation] Clock for all seasons composed of functionally heterogenous SCN cells. (2009)
  • Author(s): Honma, S.
  • Organizer: International Symposium on Biological Rhythms
  • Place of Presentation: Sapporo, Hokkaido University Conference Center
  • Year and Date: 2009-08-03
• [Presentation] 関数データ解析法とその応用 (2009)
  • Author(s): 水田正弘
  • Organizer: 応用統計学会2009年度年会 特別講演
  • Place of Presentation: 東京都、統計数理研究所
  • Year and Date: 2009-08-01
• [Presentation] Clock mechanisms in mammals encoding photoperiods. (2009)
  • Author(s): Honma, S.
  • Organizer: International Congress of Physiological Societies(IUPS)2009
  • Place of Presentation: Japan, International Conference Center, Kyoto
  • Year and Date: 2009-07-30
• [Presentation] Manipulation of the timing of self-initiated saccades by electrical stimulation of the primate dorsomedial frontal cortex (2009)
  • Author(s): Kunimatsu J, Tanaka M
  • Organizer: The 36th International Congress of Physiological Sciences(IUPS2009)
  • Place of Presentation: 京都、京都国際会議場
  • Year and Date: 2009-07-28
• [Presentation] Properties of top-down signals in the primate frontal cortex during covert tracking of a moving object (2009)
  • Author(s): Matsushima A, Tanaka M
  • Organizer: The 36th International Congress of Physiological Sciences(IUPS2009)
  • Place of Presentation: 京都、京都国際会議場
  • Year and Date: 2009-07-28
• [Presentation] Photic regulation of phase and tau ; adaptive role of a kinase in the SCN (2009)
  • Author(s): Honma, S.
  • Organizer: Gordon Conference on Chronobiology
  • Place of Presentation: USA, Slave Regina Collage, New Port, RI
  • Year and Date: 2009-07-23
• [Presentation] Preventive effect of H.pylori eradication for development of gastric cancer (2009)
  • Author(s): Kato M
  • Organizer: Sapporo Cancer Seminar 2009 29^<th> International Symposium on Cancer
  • Place of Presentation: Sapporo, The Hokkaido University Conference Hall
  • Year and Date: 2009-07-14
• [Presentation] CD133^+癌幹細胞に高発現するuPAは活性型TGF-β産生促進を介してTregを誘導する (2009)
  • Author(s): 茶本健司, et al.
  • Organizer: 第13回がん免疫学会総会
  • Place of Presentation: 福岡、北九州国際会議場
  • Year and Date: 2009-06-25
• [Presentation] 隋外造血を伴った腎周囲形質細胞腫の1例 (2009)
  • Author(s): 森田亮、神島保、白土博樹、寺江聡、久保田佳奈子、中野史人、矢部一郎、丸山覚、三村理恵
  • Organizer: 第120回北日本地方会
  • Place of Presentation: 弘前、ホテルニューキャッスル
  • Year and Date: 2009-06-19
• [Presentation] 巨大頚部リンパ節転移を伴った上咽頭がんの一例 (2009)
  • Author(s): 西川昇、長谷川雅一、安田耕一、鬼丸力也、白土博樹
  • Organizer: 第120回北日本地方会
  • Place of Presentation: 弘前、ホテルニューキャッスル
  • Year and Date: 2009-06-19
• [Presentation] 頭頚部癌におけるアンジオCT : Conventional CTとConebeam CTの比較検討 (2009)
  • Author(s): 吉田大介、寺江聡、白土博樹、工藤與亮
  • Organizer: 第120回北日本地方会
  • Place of Presentation: 弘前、ホテルニューキャッスル
  • Year and Date: 2009-06-19
• [Presentation] 定位放射線治療-肝細胞癌に対する新たな局所療法- (2009)
  • Author(s): 沖本智昭
  • Organizer: 日本癌局所療法研究会
  • Place of Presentation: 山口、宇部全日空ホテル
  • Year and Date: 2009-06-05
• [Presentation] Neuronal correlates of covert tracking of visual stimuli in the prefrontal cortex (2009)
  • Author(s): Tanaka M
  • Organizer: The 19th Annual Meeting of Neural Control of Movement
  • Place of Presentation: Hawaii Waikoloa Beach Mariott
  • Year and Date: 2009-05-02
• [Presentation] Effects of microstimulation in the primate dorsomedial frontal cortex on the timing of self-initiated saccades (2009)
  • Author(s): Kunimatsu J, Tanaka M
  • Organizer: 19th Annual Meeting of Neural Control of Movement
  • Place of Presentation: Hawaii, Waikoloa Beach Mariott
  • Year and Date: 2009-05-01
• [Presentation] A crucial role of cancer stem cell for the regulation of immunosuppressive tumor escape via Treg induction. (2009)
  • Author(s): Chamoto K, et al.
  • Organizer: American Association for Cancer Research 100th Annual Meeting.
  • Place of Presentation: USA, Colorado Convention Cente, Denver
  • Year and Date: 2009-04-21
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development (2010)
  • Author(s): Honma, S.
  • Total Pages: 303
  • Publisher: Springer
• [Book] 第7章 注意と眼球運動 In:イラストレクチャー認知神経科学(pp.108-124, ISBN : 978-4-274-20822-5)(村上郁也編) (2010)
  • Author(s): 河原純一郎、田中真樹
  • Total Pages: 302
  • Publisher: オーム社、東京
• [Book] 睡眠学 (2009)
  • Author(s): 本間さと
  • Total Pages: 735
  • Publisher: 朝倉書店
• [Book] 光周性の分子生物学 (2009)
  • Author(s): 吉川朋子
  • Total Pages: 199
  • Publisher: シュプリンガー・ジャパン
• [Book] Atlas of Gastroenterology, 4th Edition (2009)
  • Author(s): David Y, Graham, Horiuchi A, Kato M
  • Total Pages: 14
  • Publisher: Peptic ulcer disease
• [Book] 日本臨床腫瘍学会編:新臨床腫瘍学(改訂第2版),放射線腫瘍学,pp.236-245 (2009)
  • Author(s): 早川和重(分担)
  • Total Pages: 922
  • Publisher: 南江堂,東京
• [Book] Thalamic roles in eye movements in : Oxford Handbook on Eye Movements(S.P.Liversedge I.D.Glichrist, S.Everling, Eds.)
  • Author(s): Tanaka M, Kunimatsu J
  • Publisher: Oxford University Press, UK(In press)