動体追跡医科学研究

2012 Fiscal Year Annual Research Report

• Project/Area Number: 21249065
• Research Institution: Hokkaido University
• Principal Investigator: 白土 博樹 北海道大学, 医学(系)研究科(研究院), 教授 (20187537)
• Co-Investigator(Kenkyū-buntansha): 本間 さと 北海道大学, 医学(系)研究科(研究院), 特任教授 (20142713) ; 玉木 長良 北海道大学, 医学(系)研究科(研究院), 教授 (30171888) ; 久下 裕司 北海道大学, アイソトープ総合センター, 教授 (70321958) ; 水田 正弘 北海道大学, 情報科学研究科, 教授 (70174026) ; 伊達 広行 北海道大学, 保健科学研究院, 教授 (10197600) ; 田中 真樹 北海道大学, 医学(系)研究科(研究院), 教授 (90301887) ; 芳賀 永 北海道大学, 先端生命科学研究科(研究院), 准教授 (00292045) ; 西岡 健 北海道大学, 保健科学研究院, 教授 (80271659) ; 加藤 元嗣 北海道大学, 大学病院, 准教授 (60271673) ; 大泉 聡史 北海道大学, 大学病院, 准教授 (10421968) ; 松永 尚文 山口大学, 医学(系)研究科(研究院), 教授 (40157334) ; 早川 和重 北里大学, 医学部, 教授 (70114189) ; 西尾 禎治 独立行政法人国立がん研究センター, 臨床開発センター粒子線医学開発部 粒子線生物学室, 室長 (40415526) ; 但野 茂 北海道大学, 工学(系)研究科(研究院), 教授 (50175444) ; 石川 正純 北海道大学, 医学(系)研究科(研究院), 教授 (80314772) ; 小野寺 康仁 北海道大学, 医学(系)研究科(研究院), 助教 (90435561) ; 澁谷 景子 山口大学, 医学(系)研究科(研究院), 教授 (50335262) ; 浜田 俊幸 北海道大学, 医学(系)研究科(研究院), 特任准教授 (20360208) ; 鬼丸 力也 北海道大学, 医学(系)研究科(研究院), 准教授 (80374461) ; 清水 伸一 北海道大学, 医学(系)研究科(研究院), 特任准教授 (50463724) ; 土屋 和彦 北海道大学, 大学病院, 准教授 (60580892) ; 加藤 徳雄 北海道大学, 大学病院, 助教 (80572495) ; 木下 留美子 北海道大学, 医学(系)研究科(研究院), 特任助教 (70507582) ; 井上 哲也 北海道大学, 大学病院, 助教 (10431363) ; 小野寺 俊輔 北海道大学, 医学(系)研究科(研究院), 特任助教 (30374458) ; 高尾 聖心 北海道大学, 医学(系)研究科(研究院), 特任助教 (10614216) ; 加賀 基知三 北海道大学, 大学病院, 講師 (80224335)
• Project Period (FY): 2009-04-01 – 2013-03-31
• Keywords: 動体追跡 / 細胞遊走 / 放射線治療 / 胃癌 / 低酸素細胞

Research Abstract

最終年度は、生体の動きを細胞からヒトのあらゆるレベルで、リアルタイムに計測することで、新たな動体追跡医科学という領域を切り開く試みが行われた。１．放射線照射後に生残したヒト肺腺癌由来細胞A549細胞の浸潤能が照射前よりも亢進するメカニズムは、アクチン結合タンパク質の一つであるFilaminBの発現が上昇し、浸潤能の亢進をもたらすことが明らかとなった。２．小動物の追跡を実用可能とする技術的要件を明らかにし、複数同時動体追跡を可能にし、その有効性を明らかにした。長期間覚醒マウスの組織部位からの遺伝子発現を示す発光を２台のカメラで同時に追跡し、かつ発光量を定量する３次元動体追跡法を完成し、覚醒マウスの in vivo 発光イメージングによる遺伝子発現を連続的に長期間計測できる方法が確立された。３．食道、胃、十二指腸の粘膜下層に粘膜下層剥離術の技術を応用して、金ボールマーカーの挿入法を確立。バルーン小腸鏡を活用し、臨床的に胃リンパ腫などを対象に金ボールを埋め込み、合併症なくRTRT施行された。これにより、全消化管に金ボールマーカーの挿入は技術的に可能となり、これまで以上にRTRTの適用が拡大できることが判明した。４．動体追跡照射を行う場合に、Linear-quadratic model (LQ model)を利用した適切な線量分割方法の導出法に関する検討を進め、グラフィカル表示法を開発した。５．実験動物の脳に治療用放射線の定位照射を行い、マカクサルの脳の一部への放射線照射の影響をMRIと行動解析によって追跡調査した例はなく、本研究が世界初の試みとなる。今年度は２頭のサルの前頭眼野を中心とし領域に計３回の照射を行った。照射後数週間は浮腫が著明であり、行動指標として用いた眼球運動にも軽度の変化が認められたが、１か月程度の経過で画像所見、行動ともに照射前のレベルに落ち着いた。

Current Status of Research Progress

Reason

24年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

24年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Symptomatic Outcomes in Relation to Tumor Expansion After Fractionated Stereotactic Radiation Therapy for Vestibular Schwannomas: Single-Institutional Long-Term Experience (2013)
  • Author(s): Aoyama H, Onodera S, Takeichi N, Onimaru R, Terasaka S, Sawamura Y, Shirato H
  • Journal Title: Int J Radiat Oncol BiolPhys Volume: 1;85(2) Pages: 329-334
  • DOI: doi:10.1016/j.ijrobp.2012.05.003
  • Peer Reviewed
• [Journal Article] Irradiation-tolerant Lung Cancer Cells Acquire Invasive Ability Dependent on Dephosphorylation of the Myosin Regulatory Light Chain (2013)
  • Author(s): S. Ishihara, M. Yasuda, T. Nishioka, T. Mizutani, K. Kawabata, H. Shirato and H. Haga
  • Journal Title: FEBS Letters Volume: 587 Pages: 732-736
  • Peer Reviewed
• [Journal Article] Stereotactic body radiotherapy using gated radiotherapy with real-time tumor-tracking for stage I non-small cell lung cancer (2013)
  • Author(s): Inoue T, Katoh N, Onimaru R, Shimizu S, Tsuchiya K, Suzuki R, Sakakibara-Konishi J, Shinagawa N, Oizumi S, Shirato H
  • Journal Title: Radiat Oncol Volume: 8(1):69 Pages: -
  • DOI: doi: 10.1186/1748-717X-8-69
  • Peer Reviewed
• [Journal Article] Contrast-enhanced whole body joint MR Imaging in rheumatoid patients on tumour necrosis factor-alpha agents: a pilot study to evaluate novel scoring system for MR synovitis (2013)
  • Author(s): Kamishima T, Kato M, Atsumi T, Koike T, Onodera Y, Terae S
  • Journal Title: Clin Exp Rheumatol Volume: 31(1) Pages: 154
  • Peer Reviewed
• [Journal Article] Irradiation-tolerant lung cancer cells acquire invasive ability dependent on dephosphorylation of the myosin regulatory light chain (2013)
  • Author(s): Ishihara S, Yasuda M, Nishioka T, Mizutani T, Kawabata K, Shirato H, Haga H
  • Journal Title: FEBS Lett Volume: 587(6) Pages: 732-736
  • DOI: doi: 10.1016/j.febslet.2013.01.055
  • Peer Reviewed
• [Journal Article] Differential responses of circadian Per2 expression rhythms in discrete brain areas to daily injection of methamphetamine and restricted feeding in rats. (2013)
  • Author(s): Natsubori A. et al.
  • Journal Title: Eur.J.Neurosci. Volume: 37 Pages: 251-258
  • DOI: doi: 10.1111/ejn.12034.
  • Peer Reviewed
• [Journal Article] Daily exposure to cold phase-shifts circadian clock of neonatal rat in vivo. (2013)
  • Author(s): Yoshikawa T et al.
  • Journal Title: Eur.J.Neurosci. Volume: 37 Pages: 491-497
  • DOI: doi: 10.1038/embor.2012.37.
  • Peer Reviewed
• [Journal Article] High reproducibility of tumor hypoxia evaluated by 18F-fluoromisonidazole PET for head and neck cancer. (2013)
  • Author(s): Okamoto S, Shiga T, Yasuda K, Ito YM, Magota K, Kasai K, Kuge Y, Shirato H, Tamaki N
  • Journal Title: J Nucl Med Volume: 54卷 Pages: 201-207
  • DOI: doi: 10.2967/jnumed.112.109330.
  • Peer Reviewed
• [Journal Article] Biological characteristics of intratumoral [F-18] fluoromisonidazole distribution in a rodent model of glioma (2013)
  • Author(s): Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno N, Hanzawa H, Sakamoto T, Tamaki N, Kuge Y
  • Journal Title: Int J Oncol Volume: 42卷 Pages: 823-830
  • DOI: doi: 10.3892/ijo.2013.1781
  • Peer Reviewed
• [Journal Article] Monitoring tumor proliferative response to radiotherapy using (18)F-fluorothymidine in human head and neck cancer xenograft in comparison with Ki-67 (2013)
  • Author(s): Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima KI, Tamaki N, Kitagawa Y, Kuge Y
  • Journal Title: Ann Nucl Med Volume: - Pages: -
  • Peer Reviewed
• [Journal Article] Retrospective and prospective information coding by different neurons in the prefrontal cortex. (2013)
  • Author(s): Matsushima, A. & Tanaka, M.
  • Journal Title: NeuroReport Volume: 24 Pages: 73-78
  • DOI: doi: 10.1097/WNR.0b013e32835c8d66
  • Peer Reviewed
• [Journal Article] Manipulation of object choice by electrical microstimulation in macaque frontal eye fields. (2013)
  • Author(s): Matsushima, A. & Tanaka, M.
  • Journal Title: Cereb. Cortex Volume: - Pages: -
  • Peer Reviewed
• [Journal Article] Changes in Endoscopic Findings of Gastritis after Cure of H. pylori Infection: Multicenter Prospective Tria (2013)
  • Author(s): Kato M, TeraoS, et
  • Journal Title: Dig Endosc: Volume: - Pages: -
  • DOI: doi: 10.1111/j.1443-1661.2012.01385.x
  • Peer Reviewed
• [Journal Article] Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori. (2013)
  • Author(s): Haneda M, Kato M, Ishigaki S, Suzuki M, Takahashi M, Nakagawa M, Ono S, Mori Y, Mabe K, Kudo T, Nakagawa S, Shimizu Y, Asaka M.
  • Journal Title: J Gastroenterol Hepatol. Volume: 28 Pages: 78-83
  • DOI: doi: 10.1111/j.1440-1746.2012.07285.x.
  • Peer Reviewed
• [Journal Article] Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking- Ultrasonography Test. (2013)
  • Author(s): Hata T. Kato M. Kudo T. Nishida M. Nishida U. Imai A. Yoshida T. Hirota J. Kamada G. Ono S. Nakagawa M. Nakagawa, S. Shimizu, Y. Takeda H. Asaka M.
  • Journal Title: Digestion Volume: 87 Pages: 34-39
  • DOI: doi:10.1159/000343935
  • Peer Reviewed
• [Journal Article] Endoscopic resection (endoscopic mucosal resection/ endoscopic submucosal dissection) for superficial esophageal squamous cell carcinoma: Current status of various techniques. (2013)
  • Author(s): Shimizu Y, Takahashi M, Yoshida T, Ono S, Mabe K, Kato M, Asaka M, Sakamoto N.
  • Journal Title: Digestive Endosc Volume: Suppl 1 Pages: 13-19
  • DOI: doi: 10.1111/j.1443-1661.2012.01408.x
  • Peer Reviewed
• [Journal Article] Clinical outcome of supracricoid laryngectomy with cricohyoidoepiglottopexy: Radiation failure versus previously untreated patients. (2013)
  • Author(s): Nakayama M, Okamoto M, Hayakawa K, Ishiyama H, Kotani S, Miyamoto S, Seino Y, Okamoto T, Soda I, Sekiguchi A.
  • Journal Title: Auris Nasus Larynx Volume: 40(2): Pages: 207-210
  • DOI: doi: 10.1016/j.anl.2012.07.014
  • Peer Reviewed
• [Journal Article] Application of the pencil-beam redefinition algorithm in heterogeneous media for proton therapy (2013)
  • Author(s): Y. Egashira, T. Nishio, K. Hotta, R. Kohno, M. Uesaka
  • Journal Title: Phys. Med. Biol. Volume: 58(4) Pages: 1169-1184
  • DOI: doi:10.1088/0031-9155/58/4/1169
  • Peer Reviewed
• [Journal Article] Conceptual design of multi-targets for accelerator-driven system experiments with 100-MeV protons (2013)
  • Author(s): Y. Takahashi, T. Azuma, T. Nishio, T. Yagi, C. H. Pyeon, T. Misawa
  • Journal Title: Annals of Nuclear Energy Volume: 54 Pages: 162-166
  • DOI: doi: 10.1016/j.anucene.2012.10.018
  • Peer Reviewed
• [Journal Article] Interfractional dose variations in the stomach and the bowels during breath-hold intensity-modulated radiotherapy for pancreatic cancer: implications for a dose-escalation strategy. (2013)
  • Author(s): Nakamura A, Shibuya K, Nakamura M, Matsuo Y, Shiinoki T, Nakata M, Mizowaki T, Hiraoka M
  • Journal Title: Medical Physics Volume: 40(2) Pages: 121701 1-9
  • DOI: doi: 10.1118/1.4773033
  • Peer Reviewed
• [Journal Article] Differences in the dose-volume metrics with heterogeneity correction status and its influence on local control in stereotactic body radiation therapy for lung cancer. (2013)
  • Author(s): Ueki N, Matsuo Y, Shibuya K, Nakamura M, Narabayashi M, Sakanaka K,Norihisa Y, Mizowaki T, Hiraoka M
  • Journal Title: J Radiat Res Volume: 54(2) Pages: 337-343
  • DOI: doi: 10.1093/jrr/rrs084
  • Peer Reviewed
• [Journal Article] Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning (2012)
  • Author(s): Masahiro Mizuta, Hiroyuki Date, Seishin Takao, Naoki Kishimoto, Kenneth L. Sutherland, Rikiya Onimaru, and Hiroki Shirato
  • Journal Title: Medical Physics Volume: 39 (11) Pages: 6791-6795
  • DOI: doi:10.1118/1.4757580
  • Peer Reviewed
• [Journal Article] Clinical Outcomes of Stereotactic Body Radiotherapy for Patients with Lung Tumors in the State of Oligorecurrence (2012)
  • Author(s): Inoue T, Katoh N, Onimaru R, Shirato H
  • Journal Title: Pulmonary Medicine Volume: 2012:369820 Pages: -
  • DOI: doi:10.1155/2012/369820
  • Peer Reviewed
• [Journal Article] Preoperative percutaneous transhepatic portal vein embolization with ethanol injection (2012)
  • Author(s): Sakuhara Y, Abo D, Hasegawa Y, Shimizu T, Kamiyama T, Hirano S, Fukumori D, Kawamura T, Ito YM, Tha KK, Shirato H, Terae S
  • Journal Title: AJR Am J Roentgenol. Volume: 198(4) Pages: 914-922
  • DOI: doi: 10.2214/AJR.11.6515.
  • Peer Reviewed
• [Journal Article] Feasibility of a dual microcatheter-dual interlocking detachable coil technique in preoperative embolization in preparation for distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer (2012)
  • Author(s): Abo D, Hasegawa Y, Sakuhara Y, Terae S, Shimizu T, Tha KK, Tanaka E, Hirano S, Kondo S, Shirato H
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 19(4) Pages: 431-437
  • DOI: doi: 10.1007/s00534-011-0455-9
  • Peer Reviewed
• [Journal Article] Usefulness of portography and contrast-enhanced computed tomography to predict the embolized area in percutaneous transhepatic portal vein embolization with absolute ethanol under temporary balloon occlusion (2012)
  • Author(s): Hasegawa Y, Abo D, Sakuhara Y, Kato F, Kamishimma T, Shimizu T, Ito YM, Terae S, Shirato H
  • Journal Title: Jpn J Radiol Volume: 30(1) Pages: 53-61
  • DOI: doi: 10.1007/s11604-011-0008-9
  • Peer Reviewed
• [Journal Article] Guidelines for respiratory motion management in radiation therapy (2012)
  • Author(s): Matsuo Y, Onishi H, Nakagawa K, Nakamura M, Ariji T, Kumazaki Y, Shimbo M, Tohyama N, Nishio T, Okumura M, Shirato H, Hiraoka M
  • Journal Title: J Radiat Res Volume: - Pages: -
  • Peer Reviewed
• [Journal Article] Regional control after concomitant chemoradiotherapy without planned neck dissection in node-positive head and neck squamous cell carcinomas (2012)
  • Author(s): Sakashita T, Homma A, Oridate N, Suzuki S, Hatakeyama H, Kano S, Mizumachi T, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
  • Journal Title: Auris Nasus Larynx Volume: - Pages: -
  • DOI: doi: 10.1016/j.anl.2012.07.002
  • Peer Reviewed
• [Journal Article] A Mathematical Study to Select Fractionation Regimen Based on Physical Dose Distribution and the Linear-Quadratic Model (2012)
  • Author(s): Mizuta M, Takao S, Date H, Kishimoto N, Sutherland KL, Onimaru R, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 84(3) Pages: 829-833
  • DOI: doi: 10.1016/j.ijrobp.2012.01.004
  • Peer Reviewed
• [Journal Article] De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide. (2012)
  • Author(s): Nishide S. et al.
  • Journal Title: Eur J Neurosci Volume: 35 Pages: 291-299
  • DOI: doi: 10.1111/j.1460-9568.2011.07952.x.
  • Peer Reviewed
• [Journal Article] Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis. (2012)
  • Author(s): Kwon HJ et. al
  • Journal Title: Cell Death and Disease Volume: 3 Pages: e278
  • DOI: doi: 10.1038
  • Peer Reviewed
• [Journal Article] JNK regulates the photic response of the mammalian circadian clock. (2012)
  • Author(s): Yoshitane H. et al.
  • Journal Title: EMBO Report Volume: 13 Pages: 455-461
  • DOI: doi: 10.1038/embor.2012.37.
  • Peer Reviewed
• [Journal Article] Single-cell resolution fluorescence imaging of circadian rhythms detected with a Nipkow spinning disk confocal system. (2012)
  • Author(s): Enoki R. et al.
  • Journal Title: J Neurosci Methods Volume: 202 Pages: 72-79
  • DOI: doi: 10.1016/j.jneumeth.2012.03.004.
  • Peer Reviewed
• [Journal Article] Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus. (2012)
  • Author(s): Enoki R. et al.
  • Journal Title: Proc. Natl. Acad.Sci USA Volume: 109 Pages: 21498-21503
  • DOI: doi: 10.1038/embor.2012.37.
  • Peer Reviewed
• [Journal Article] Suprachiasmatic nucleus: cellular clocks and networks. (2012)
  • Author(s): Honma S et al.
  • Journal Title: Prog Brain Res Volume: 199 Pages: 129-141
  • DOI: pii: S0168-0102(13)00005-9. 10.1016/j.neures
  • Peer Reviewed
• [Journal Article] 18F-Fluoromisonidazole positron emission tomographymay differentiate glioblastoma multiforme from lessmalignant gliomas (2012)
  • Author(s): Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, Yamaguchi S,Houkin K, Tanaka S, KugeY, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 39卷 Pages: 760-770
  • DOI: doi: 10.1007/s00259-011-2037-0
  • Peer Reviewed
• [Journal Article] Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma (2012)
  • Author(s): Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y
  • Journal Title: Int J Oncol Volume: 41卷 Pages: 1593-1600
  • DOI: doi: 10.3892/ijo.2012.1624.
  • Peer Reviewed
• [Journal Article] 医薬品開発（又は創薬・育薬）における分子イメージング技術の現状と進歩 (2012)
  • Author(s): 久下裕司、西嶋剣一、孫田恵一、趙松吉、玉木長良
  • Journal Title: 医薬品医療機器レギュラトリーサイエンス Volume: 43卷 Pages: 308-313
• [Journal Article] A Mathematical Study to Select Fractionation Regimen based on Physical Dose Distribution and the Linear-Quadratic Model, (2012)
  • Author(s): M. Mizuta, S. Takao, H. Date, N. Kishimoto, K. L. Sutherland,R. Onimaru, and H. Shirato
  • Journal Title: International Journal of Radiation Oncology, Biology Volume: Vol.84, No.3 Pages: 829-833
  • DOI: doi:10.1016/j.ijrobp.2012.01.004
  • Peer Reviewed
• [Journal Article] Graphical Representation of the Effects on Tumor and OAR for Determining the Appropriate Fractionation Regimen in Radiation Therapy Planning (2012)
  • Author(s): M. Mizuta, H. Date, S. Takao, N. Kishimoto, K. L. Sutherland,R. Onimaru, H. Shirato
  • Journal Title: Medical Physics Volume: Vol.39, No.11 Pages: 6791-6795
  • DOI: doi: 10.1118/1.4757580
  • Peer Reviewed
• [Journal Article] A Simulation Study of the Radiation-Induced Bystander Effect: Modeling with Stochastically Defined Signal Reemission (2012)
  • Author(s): Kohei Sasaki, Kosuke Wakui, Kaori Tsutsumi, Akio Itoh, and Hiroyuki Date
  • Journal Title: Computational and Mathematical Methods in Medicine Volume: 2012 Pages: 5 pages
  • DOI: doi:10.1155/2012/389095
  • Peer Reviewed
• [Journal Article] Investigation of the change in marker geometry during respiration motion: a preliminary study for dynamic-multi-leaf real-time tumor tracking (2012)
  • Author(s): Rie Yamazaki, Seiko Nishioka, Hiroyuki Date, Hiroki Shirato, Takao Koike, and Takeshi Nishioka
  • Journal Title: Radiation Oncology Volume: 7:218 Pages: 5 pages
  • DOI: doi:10.1186/1748-717X-7-218
  • Peer Reviewed
• [Journal Article] Neuronal correlates of multiple top-down signals during covert tracking of moving objects in macaque prefrontal cortex. (2012)
  • Author(s): Matsushima, A. & Tanaka, M.
  • Journal Title: J. Cogn. Neurosci. Volume: 24 Pages: 2043-2056
  • DOI: doi: 10.1162/jocn_a_00265
  • Peer Reviewed
• [Journal Article] Alteration of the timing of self-initiated but not reactive saccades by electrical stimulation in the supplementary eye field. (2012)
  • Author(s): Kunimatsu, J. & Tanaka, M.
  • Journal Title: Eur. J. Neurosci. Volume: 36 Pages: 3258-3268
  • DOI: doi: 10.1111/j.1460-9568.2012.08242.x
  • Peer Reviewed
• [Journal Article] 視床-大脳皮質経路による運動の制御：ニホンザルの眼球運動を指標とした研究（Role of the primate thalamocortical pathways in the generation of eye movements.） (2012)
  • Author(s): 國松 淳、田中真樹
  • Journal Title: 比較生理生化学会誌 Volume: 29 Pages: 235-241
  • Peer Reviewed
• [Journal Article] The Number of Cyclic Stretch Regulates Cellular Elasticity in C2C12 Myoblasts (2012)
  • Author(s): K. Takemoto, T. Mizutani, K. Tamura, K. Takeda, H. Haga, K. Kawabata
  • Journal Title: Open Journal of Cell Biology Volume: 2 Pages: 1-10
  • DOI: doi: 10.4236/cellbio.2012.11001
  • Peer Reviewed
• [Journal Article] Investigation of the change in marker geometry during respiration motion: a preliminary study for dynamic-multi-leaf real-time tumor tracking. (2012)
  • Author(s): Yamazaki R, Nishioka S, Date H, Shirato H, Koike T, Nishioka T.
  • Journal Title: Radiation Oncology. Volume: 18 Pages: 218-222
  • DOI: doi:10.1186/1748-717X-7-218
  • Peer Reviewed
• [Journal Article] Recent Develop -ment of Gastric Cancer Prevention (2012)
  • Author(s): Kato M, Asaka M.
  • Journal Title: Jpn J Clin Oncol. Volume: 42 Pages: 987-994
  • DOI: doi: 10.1093/jjco/hys151.
  • Peer Reviewed
• [Journal Article] Relationship between Diffusion-Weighted Magnetic Resonance Imaging and Histological Tumor Grading of Hepatocellular Carcinoma (2012)
  • Author(s): Nakanishi M, Chuma M, Hige S, Omatsu T, Yokoo H, Nakanishi K, Kamiyama T, Kubota K, Haga H, Matsuno Y, Onodera Y, Kato M, Asaka M.
  • Journal Title: Ann Surg Oncol Volume: 19 Pages: 1302-1309
  • DOI: doi: 10.1245/s10434-011-2066-8.
  • Peer Reviewed
• [Journal Article] Efficacy of carbon dioxide-insufflating colonoscopy in patients with irritable bowel syndrome (IBS): a randomized double-blind study. (2012)
  • Author(s): Imai A, Kato M, Ono S, Shimizu Y, Takeda H, Asaka M.
  • Journal Title: J Gastroenterol Hepatol. Volume: 27 Pages: 1623-1628
  • DOI: doi: 10.1111/j.1440-1746.2012.07208.x
  • Peer Reviewed
• [Journal Article] Coccoid Helicobacter pylori Can Directly Adhere and Invade in Agminated Formation to Human Gastric Epithelial Cells. (2012)
  • Author(s): Saito N, Ooi HK, Konishi K, Shoji E, Kato M, Asaka M
  • Journal Title: Advances in Microbiology Volume: 2 Pages: 112-116
  • DOI: doi:10.4236/aim.2012.22015
  • Peer Reviewed
• [Journal Article] Frequency of Helicobacter pylori -Negative Gastric Cancer and Gastric Mucosal Atrophy in a Japanese Endoscopic Submucosal Dissection Series Including Histological, Endoscopic and Serological Atrophy. (2012)
  • Author(s): Ono S, Kato M, Suzuki M, Ishigaki S, Takahashi M, Haneda M, Mabe K, Shimizu Y.
  • Journal Title: Digestion Volume: 86 Pages: 59-65
  • DOI: doi: 10.1159/000339176.
  • Peer Reviewed
• [Journal Article] Phase I results of vinorelbine with concurrent radiotherapy in elderly patients with unresectable, locally advanced non-small-cell lung cancer: West Japan Thoracic Oncology Group (WJTOG3005-DI). (2012)
  • Author(s): Harada H, Seto T, Igawa S, Tsuya A, Wada M, Kaira K, Naito T, Hayakawa K, Nishimura T, Masuda N, Yamamoto N.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(5) Pages: 1777－1782
  • DOI: doi: 10.1016/j.ijrobp.2011.03.037
  • Peer Reviewed
• [Journal Article] Diffusion-weighted imaging of local recurrent prostate cancer after radiation therapy: comparison with 22-core three-dimensional prostate mapping biopsy. (2012)
  • Author(s): Hara T, Inoue Y, Satoh T, Ishiyama H, Sakamoto S, Woodhams R, Baba S, Hayakawa K.
  • Journal Title: Magn Reson Imaging. Volume: 30(8) Pages: 1091－1098
  • DOI: doi: 10.1016/j.mri.2012.04.022.
  • Peer Reviewed
• [Journal Article] Huidelines for respiratory motion management in radiation therapy (2012)
  • Author(s): Y. Matsuo, H. Onishi, K. Nakagawa, M. Nakamura, T. Ariji, Y. Kumazaki, M. Shimbo, N. Tohyama, T. Nishio, M. Okumura, H. Shirato, M. Hiraoka
  • Journal Title: J. Rad. Res. Volume: - Pages: -
  • DOI: doi: 10.1093/jrr/rrs122
  • Peer Reviewed
• [Journal Article] Impact of early radiological response evaluation on radiotherapeutic outcomes in the patients with nasal cavity and paranasal sinus malignacies (2012)
  • Author(s): H. Hojo, S. Zenda, T. Akimoto, R. Kohno, M. Kawashima, S. Arahira, T. Nishio, M. Tahara, R. Hayashi, K. Sasai
  • Journal Title: J. Radiat. Res. Volume: 53 Pages: 704-709
  • DOI: doi: 10.1093/jrr/rrs021
  • Peer Reviewed
• [Journal Article] Experimental evaluation of a spatial resampling technique to improve the accuracy of pencil-beam dose calculation in proton therapy (2012)
  • Author(s): Y. Egashira, T. Nishio, T. Matsuura, S. Kameoka, M. Uesaka
  • Journal Title: Med. Phys. Volume: 39(7) Pages: 4104-4114
  • DOI: doi: 10.1118/1.4722984
  • Peer Reviewed
• [Journal Article] Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion. (2012)
  • Author(s): Onodera Y, Nam JM, Hashimoto A, Norman JC, Shirato H, Hashimoto S, Sabe H
  • Journal Title: The Journal of Cell Biology Volume: 197 Pages: 983-996
  • DOI: doi: 10.1083
  • Peer Reviewed
• [Journal Article] Analysis of dosimetric parameters associated with acute gastrointestinal toxicity and upper gastrointestinal bleeding in locally advanced pancreatic cancer patients treated with gemcitabine-based concurrent chemoradiotherapy. (2012)
  • Author(s): Nakamura A, Shibuya K, Matsuo Y, Nakamura M, Shiinoki T, Mizowaki T, Hiraoka M
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 84(2) Pages: 369-375
  • DOI: doi: 10.1016/j.ijrobp.2011.12.026
  • Peer Reviewed
• [Journal Article] Preliminary report of late recurrences, at 5 years or more, after stereotactic body radiation therapy for non-small cell lung cancer. (2012)
  • Author(s): Matsuo Y, Shibuya K, Nagata Y, Norihisa Y, Narabayashi M, Sakanaka K, Ueki N, Mizowaki T, Hiraoka M
  • Journal Title: J Thoracic Oncol Volume: 7(2): Pages: 453-456
  • DOI: doi: 10.1097/JTO.0b013e31823c5b29
  • Peer Reviewed
• [Journal Article] JNK regulates the photic response of the mammalian circadian clock (2012)
  • Author(s): Yoshitane H et al.
  • Journal Title: EMBO Report Volume: Vol.13 Pages: 445-461
  • DOI: doi: 10.1038/embor.2012.37
  • Peer Reviewed
• [Journal Article] 術前臨床データによる小型肺癌に対する縮小手術の適応 (2012)
  • Author(s): 樋田泰浩、寺村鉱一、武藤潤、大高和人、長谷龍之介、中田玲子、渡邊祐介、松居喜郎、加賀基知三
  • Journal Title: 胸部外科 Volume: 65 Pages: 52-57
• [Presentation] 動体追跡技術による全身の時計遺伝子発現定量解析と行動解析 (2013)
  • Author(s): 浜田俊幸
  • Organizer: 第155回日本獣医学会学術大会
  • Place of Presentation: 東京大学駒場キャンパス(東京都）
  • Year and Date: 20130328-20130330
• [Presentation] 動体追跡技術による全身の時計遺伝子発現定量解析と行動解析 (2013)
  • Author(s): 浜田俊幸
  • Organizer: 155回日本獣医学会大会
  • Place of Presentation: 東京大学駒場キャンパス(東京都）
  • Year and Date: 20130328-20130330
  • Invited
• [Presentation] 標的原子核破砕反応と高精度陽子線がん治療に関する研究 (2013)
  • Author(s): 西尾禎治、松下慶一郎、関根雅晃、宮武彩
  • Organizer: 日本物理学会第６８回年次大会
  • Place of Presentation: 広島大学(東広島市)
  • Year and Date: 20130326-20130329
• [Presentation] Development of RTP System with the Plug-in Function for Various Radiation Therapy System (2013)
  • Author(s): T. Nishio
  • Organizer: Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, Symposium
  • Place of Presentation: Convention Center（Hokkaido)
  • Year and Date: 20130207-20130208
  • Invited
• [Presentation] A Mathematical Method for Estimating Optimal Fractionation Regimen in Radiotherapy (2013)
  • Author(s): Seishin Takao, Masahiro Mizuta, Hiroyuki Date, Yuriko Komiya, Kenneth L. Sutherland, Rikiya Onimaru, and Hiroki Shirato
  • Organizer: 3rd International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • Place of Presentation: Hokkaido University（Sapporo）
  • Year and Date: 20130207-20130208
• [Presentation] Involvement of cell polarity and cell migration in folding phenomena of epithelial sheets (2012)
  • Author(s): S. Ishida, R. Tanaka, N. Yamaguchi, T. Mizutani, K. Kawabata, H. Haga
  • Organizer: 第52回米国細胞生物学会年会
  • Place of Presentation: モスコーンセンター（米国）
  • Year and Date: 20121215-20121219
• [Presentation] EGFR and Integrin α2β1 Dependent Invasiveness of Lung Adenocarcinoma Cells that Survived 10 Gy Ionizing Radiation (2012)
  • Author(s): X. Li, S. Ishihara, M. Yasuda, T. Mizutani, K. Kawabata, T. Nishioka, H. Haga
  • Organizer: 第52回米国細胞生物学会年会
  • Place of Presentation: モスコーンセンター（米国）
  • Year and Date: 20121215-20121219
• [Presentation] Collective behavior of epithelial cells responding to stiffness, roughness and composition of extracellular matrix (2012)
  • Author(s): 芳賀 永
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 20121211-20121214
  • Invited
• [Presentation] Multiple components of prefrontal signals for covert tracking of moving object (2012)
  • Author(s): 田中真樹
  • Organizer: The 3rd International Symposium on Prefrontal Cortex- Searching for Mechanism of Mind
  • Place of Presentation: Kyoto Univ Inamori Cntr.（京都市）
  • Year and Date: 20121129-20121130
  • Invited
• [Presentation] Naming rule in radiation therapy and its efficacy (2012)
  • Author(s): 安田耕一, 鈴木隆介, 藤田勝久, 清水伸一, 鬼丸力也, 加藤徳雄, 木下留美子, 西岡健太郎, 原田慶一, 白土博樹
  • Organizer: 日本放射線腫瘍学会 第25回学術大会
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Year and Date: 20121123-20121124
• [Presentation] 子宮頸癌に対する根治的化学放射線療法の検討 (2012)
  • Author(s): 原田慶一、木下留美子、西岡健太郎、小野寺俊輔、土屋和彦、加藤徳雄、清水伸一、白土博樹、長谷川雅一、北原利博
  • Organizer: 日本放射線腫瘍学会 第25回学術大会
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Year and Date: 20121123-20121124
• [Presentation] Study on Radiation Therapy with Distribution Valued Data (2012)
  • Author(s): M. Mizuta
  • Organizer: 3rd Workshop in Symbolic Data Analysis
  • Place of Presentation: Madrid, Comillas Pontifical University(Spain)
  • Year and Date: 20121107-20121109
• [Presentation] Stereotactic body radiotherapy (SBRT) using real-time tracking radiotherapy (RTRT) system for patients with lung cancer aged 80 and over (2012)
  • Author(s): Onimaru R, Katoh N, Inoue T, Shimizu S, Shinagawa N, Sakakibara-Konishi J, Oizumi S, Shirato H
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center(USA)
  • Year and Date: 20121028-20121031
• [Presentation] Decreasing acute and late toxicity using urethral dose reduction and smaller safety margin around CTV for prostate cancer intensity-modulated radiation therapy (IMRT) (2012)
  • Author(s): Shimizu S, Nishioka K, Onimaru R, Kinoshita R, Harada K, Nishikawa N, Abe T, Maruyama S, Shinohara N, Shirato H
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center(USA)
  • Year and Date: 20121028-20121031
• [Presentation] Retrospective comparison between Cisplatin plus fluorouracil and weekly Cisplatin in concurrent chemotherapy setting for stage II-IV nasopharyngeal carcinoma (2012)
  • Author(s): Tsuchiya K, Yasuda K, Nishikawa Y, Kinoshita R, Onimaru R, Shirato H
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center(USA)
  • Year and Date: 20121028-20121031
• [Presentation] Real-time tumor tracking radiation therapy for lymphoma of the stomach (2012)
  • Author(s): Katoh N, Suzuki R, Shimizu S, Inoue T, Yasuda K, Onimaru R, Kimura R, Kato M, Ishikawa M, Shirato H
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center(USA)
  • Year and Date: 20121028-20121031
• [Presentation] Interfractional setup error and intrafractional bladder motion during radiotherapy for bladder tumors (2012)
  • Author(s): Nishioka K, Shimizu S, Abe T, Maruyama S, Onimaru R, Kinoshita R, Harada K, Nishikawa N, Shinohara N, Shirato H
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center(USA)
  • Year and Date: 20121028-20121031
• [Presentation] Stereotactic body radiotherapy using gated radiotherapy with real-time tumor-tracking for stage I non-small cell lung cancer (2012)
  • Author(s): Inoue T, Katoh N, Onimaru R, Suzuki R, Sakakibara-Konishi J, Shinagawa N, Oizumi S, Hiroki Shirato H
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center(USA)
  • Year and Date: 20121028-20121031
• [Presentation] The role of spot scanning proton therapy in the treatment of large abdominal tumors: A comparative planning study of hepatocellular carcinoma (2012)
  • Author(s): Toramatsu C, Katoh N, Shimizu S, Nihongi H, Matsuura T, Takao S, Miyamoto N, Kinoshita R, Umegaki K, Shirato H
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center(USA)
  • Year and Date: 20121028-20121031
• [Presentation] Co-overexpression Of GEP100 With EGFR Correlates With Early Recurrence After Breast Conservation Therapy (BCT) (2012)
  • Author(s): Kinoshita R, Nam JM, Hosoda M, Kubota KC, Tanino M, Hashimoto A, Ito YM, Tanaka S, Sabe H, Shirato H
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center(USA)
  • Year and Date: 20121028-20121031
• [Presentation] Targeting beta1 integrin suppresses invasive recurrence in a three-dimensional model of radiation treated ductal carcinoma in situ (2012)
  • Author(s): Nam JM, Ahmed KM, Costes S, Zhang H, Sabe H, Shirato H, Park CC
  • Organizer: ASTRO 54th Annual meeting
  • Place of Presentation: Boston Convention and Exhibition Center(USA)
  • Year and Date: 20121028-20121031
• [Presentation] Phase II study of nimotuzumab in combination with concurrent chemoradiation therapy (CRT) in patients with locally advanced non-small cell lung cancer (NSCLC). (abstract: Int J Radiat Oncol Biol Phys, 84(3, Suppl): S68, 2012) (2012)
  • Author(s): Nishimura Y, Harada H, Soejima T, Tsujino K, Hayakawa K, Kozuka T, Tanaka M, Sasaki T, Yamamoto N, Nakagawa K
  • Organizer: 54th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Boston Convention and Exhibition Center（USA）
  • Year and Date: 20121028-20121031
• [Presentation] 特別講演１．癌の診断・治療効果評価におけるPETの応用～基礎研究を中心に～ 口腔顔面核医学フォーラム2012 (2012)
  • Author(s): 趙松吉、久下裕司、玉木長良
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌（札幌市）
  • Year and Date: 20121011-20121013
  • Invited
• [Presentation] 腫瘍・肉芽腫における18F-FMISO集積の特徴：18F-FDG及び組織学的比較 (2012)
  • Author(s): 趙松吉、伊敏、趙芫、西嶋剣一、村上正紘、于聞文、チョウドリ ヌスラット ファティマ、孫田恵、小華和柾志、玉木長良、久下裕司
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
  • Year and Date: 20121011-20121013
• [Presentation] 固形腫瘍内における放射線誘導性再酸素化の動態の評価 (2012)
  • Author(s): 永根大幹、安井博宣、趙松吉、久保直樹、玉木長良、久下裕司、稲波修
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
  • Year and Date: 20121011-20121013
• [Presentation] The relationship between the pretreatment uptake area of FMISO and local recurrence site in nasopharyngeal cancer (2012)
  • Author(s): Yasuda K, Tsuchiya K, Okamoto S, Onimaru R, Shiga T, Katoh N, Suzuki R, Harada K, Kuge Y, Tamaki N, Shirato H
  • Organizer: The 10th International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: 北海道医学部学友会館「フラテ」（札幌市）
  • Year and Date: 20121002-20121003
• [Presentation] Novel noninvasive imaging of clock gene expression in the olfactory bulbs and skin of freely moving mice (2012)
  • Author(s): Hamada T
  • Organizer: The 10th International Symposium for Future Drug Discovery and Medical Care" Frontiers of Interdisciplinary Research in Medicine
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 20121002-20121003
• [Presentation] 転移性脳腫瘍症例における全脳照射後の1年以内のQOLの変化について (2012)
  • Author(s): 小野寺俊輔、青山英史、鬼丸力也、白土博樹
  • Organizer: 第48回日本医学放射線学会 秋季臨床大会
  • Place of Presentation: 長崎ブリックホール（長崎県）
  • Year and Date: 20120928-20120930
• [Presentation] 低酸素イメージングと放射線治療 (2012)
  • Author(s): 安田耕一、鬼丸力也、岡本祥三、志賀哲、加藤徳雄、玉木長良、白土博樹
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
  • Year and Date: 20120919-20120921
• [Presentation] 放射線治療の最前線と癌治療 (2012)
  • Author(s): 白土博樹
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
  • Year and Date: 20120919-20120921
• [Presentation] A stiff substrate activates transcription factor NF-B and increases the adhesion area in cancer cells (2012)
  • Author(s): 石原 誠一郎、安田 元昭、芳賀 永
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: さっぽろ芸文館（北海道）
  • Year and Date: 20120919-20120921
• [Presentation] Monitoring the circadian clock’s tick; multiple hands for multiple functions. (2012)
  • Author(s): Sato Honma
  • Organizer: 4th International Symposium on Photonic Bioimaging
  • Place of Presentation: Hokkaido University Conference Center(Sapporo)
  • Year and Date: 20120916-20120917
• [Presentation] 中枢時計の発達と時計遺伝子機能 (2012)
  • Author(s): 小野大輔
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道大学学術交流会館（札幌市）
  • Year and Date: 20120915-20120916
• [Presentation] In vivo４Dイメージングによる覚醒マウス時計遺伝子発現定量解析 (2012)
  • Author(s): 浜田俊幸
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道大学学術交流会館（札幌市）
  • Year and Date: 20120915-20120916
• [Presentation] In vivo 4Dイメージングによる覚醒マウスの時計遺伝子発現定量解析 (2012)
  • Author(s): 浜田俊幸
  • Organizer: 第19回日本時間生物学術大会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 20120915-20120916
• [Presentation] 陽子線治療における最適な治療ワークフローの検討 (2012)
  • Author(s): 高尾聖心, 松浦妙子, 寅松千枝, 二本木英明, 宮本直樹, 清水伸一, 木下留美子, 松田浩二, 木谷貴雄, 梅垣菊男, 白土博樹
  • Organizer: 第104回日本医学物理学会大会
  • Place of Presentation: つくば国際会議場(つくば市)
  • Year and Date: 20120913-20120915
• [Presentation] 腫瘍の放射線治療における数理モデルについて (2012)
  • Author(s): 水田正弘、高尾聖心、伊達 広行、白土 博樹
  • Organizer: 2012年度統計関連学会連合大会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 20120909-20120912
• [Presentation] 分布値データ解析のための数学的ツールについて (2012)
  • Author(s): 水田正弘
  • Organizer: 2012年度統計関連学会連合大会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 20120909-20120912
• [Presentation] FLT can early reflect response of tumor proliferation to multikinase inhibitor (sorafenib) treatment in a human renal cell carcinoma xenograft: comparison with Ki-67 (2012)
  • Author(s): Murakami M, Zhao S, Zhao Y, Nusrat C, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y
  • Organizer: The 2012 World Molecular Imaging Congress
  • Place of Presentation: The Convention Centre Dublin - CCD( Ireland)
  • Year and Date: 20120905-20120908
• [Presentation] On-line PET imaging for proton therapy system (2012)
  • Author(s): M. Yamada, D. Amano, T. Tachikawa, M. Hirabayashi, T. Nishio
  • Organizer: 22nd International Conference on the Application of Accelerators in Research and Industry (CAARI 2012)
  • Place of Presentation: Renaissance Worthington Hotel（USA)
  • Year and Date: 20120805-20120810
• [Presentation] Optimization of Dose Fractionation based on 3D dose distribution and LQ model (2012)
  • Author(s): M. Mizuta
  • Organizer: The 31st Sapporo International Cancer Symposium 2012
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 20120723-20120724
  • Invited
• [Presentation] Invasive migration of irradiation-survived human lung adenocarcinoma cells in 3D matrix (2012)
  • Author(s): 芳賀 永
  • Organizer: 第31回札幌国際がんシンポジウム
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 20120723-20120724
  • Invited
• [Presentation] Performace of beam ON-LINE PET system constructed with two opposing planar-type detector heads in proton therapy (2012)
  • Author(s): T. Nishio, A. Miyatake, K. Matsushita, M. Sekine
  • Organizer: The 31st Sapporo International Cancer Symposium / Advanced Radiation Therapy and Cancer Research Up-to-Date
  • Place of Presentation: Hokkaido University（Sapporo）
  • Year and Date: 20120723-20120724
• [Presentation] Development of dynamic phantom for quality control in four-dimensional radiotherapy (2012)
  • Author(s): N. Miyamoto, Y. Hirata, K. Naoe, R. Suzuki, C. Toramatsu, S. Shimizu, Y. Miyabe, S. Kaneko, T. Nishio, M. Ishikawa, M. Hiraoka, H. Shirato
  • Organizer: The 31st Sapporo International Cancer Symposium / Advanced Radiation Therapy and Cancer Research Up-to-Date
  • Place of Presentation: Hokkaido University（Sapporo）
  • Year and Date: 20120723-20120724
• [Presentation] Usability of Treatment Procedure in Spot Scanning Proton Beam Therapy System (2012)
  • Author(s): Seishin Takao, Shinichi Shimizu, Taeko Matsuura, Chie Toramatsu, Hideaki Nihongi, Naoki Miyamoto, Koji Matsuda, Toru Umekawa, Kikuo Umegaki, and Hiroki Shirato
  • Organizer: 31st Sapporo International Cancer Symposium
  • Place of Presentation: Hokkaido University（Sapporo）
  • Year and Date: 20120723-20120724
• [Presentation] 覚醒マウスにおける時計遺伝子発現の４Dイメージング (2012)
  • Author(s): 浜田俊幸
  • Organizer: 第2回睡眠研究会
  • Place of Presentation: 名古屋大学（名古屋市）
  • Year and Date: 20120705-20120706
  • Invited
• [Presentation] 覚醒マウスにおける時計遺伝子発現の４Dイメージング (2012)
  • Author(s): 浜田俊幸
  • Organizer: 第2回睡眠研究会
  • Place of Presentation: 名古屋大学シンポジオン(名古屋市)
  • Year and Date: 20120704-20120705
• [Presentation] MultiTransmitとSmart Exam Breastを用いた3T乳腺MRIの画質評価 (2012)
  • Author(s): 加藤扶美 真鍋徳子 水戸寿々子 石坂欣也 小野寺祐也 三村理恵 寺江 聡 白土博樹
  • Organizer: 第20回日本乳癌学会学術総会
  • Place of Presentation: 市民会館崇城大学ホール（熊本県）
  • Year and Date: 20120627-20120630
• [Presentation] Dosimetric Comparison of Intensity Modulated Radiotherapy and Standard Wedged Tangential Technique for Whole-Breast Radiotherapy with Relatively Small Breast Volume (2012)
  • Author(s): Tsuchiya K, Kinoshita R, Nishioka K, Shimizu S, Shirato H
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: 広島国際会議場（広島市）
  • Year and Date: 20120619-20120621
• [Presentation] Optimization of energy window setting of the semiconductor PET for clinical FDG studies (2012)
  • Author(s): Shiga T, Takeuchi W, Morimoto Y, Kubo N, Hirata K, Kobasi K, Hattori N, Tamaki N
  • Organizer: The 59th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: Miami, the Miami Beach Convention Center(US)
  • Year and Date: 20120609-20120613
• [Presentation] Reproducibility of hypoxic evaluation using FMISO-PET for head and neck cancer (2012)
  • Author(s): Okamoto S, Shiga T, Yasuda K, Kasai K, Magota K, Kuge K, Shirato H, Tamaki
  • Organizer: The 59th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: Miami, the Miami Beach Convention Center(US)
  • Year and Date: 20120609-20120613
• [Presentation] FMISO PET reflects antiangiogenic tumor response to multi-kinase inhibitor (sorafenib) in human renal cell carcinoma xenograft (2012)
  • Author(s): Murakami M, Zhao S, Zhao Y, Nusrat C, Yu W, Nishijima K, Takiguchi T, Tamaki N, Kuge Y
  • Organizer: The 59th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: Miami, the Miami Beach Convention Center(US)
  • Year and Date: 20120609-20120613
• [Presentation] Radiation-induced nitric oxide contributes to the tumor reoxygenation in SCCVII tumors (2012)
  • Author(s): Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Kameya H, Nakamura H, and Inanami O N, Kuge Y
  • Organizer: The 59th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: Miami, the Miami Beach Convention Center(US)
  • Year and Date: 20120609-20120613
• [Presentation] Substrate stiffness enhances MMP-7 expression and ECM degradation in cancer cells (2012)
  • Author(s): 佐々木 千絵、桝田 浩孝、中村 公則、綾部 時芳、水谷 武臣、川端 和重、芳賀 永
  • Organizer: 第64回日本細胞生物学会大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 20120528-20120531
• [Presentation] Involvement of cell polarity in folding phenomena of epithelial sheets (2012)
  • Author(s): 石田 すみれ、田中 良昌、水谷 武臣、川端 和重、芳賀 永
  • Organizer: 第64回日本細胞生物学会大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 20120528-20120531
• [Presentation] Integrin α2 dependent increased invasiveness of lung adenocarcinoma cells that survived 10 Gy ionizing radiation (2012)
  • Author(s): 李 雪、石原 誠一郎、山田 泰士、安田 元昭、水谷 武臣、川端 和重、西岡 健、芳賀 永
  • Organizer: 第64回日本細胞生物学会大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 20120528-20120531
• [Presentation] Live cell imaging of collective migration in 3D morphogenesis of epithelial cells (2012)
  • Author(s): 今井 美沙子、水谷 武臣、川端 和重、芳賀 永
  • Organizer: 第64回日本細胞生物学会大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 20120528-20120531
• [Presentation] Modeling of Radiation-Induced Bystander Effect with Re-emitting Signals Following the Poisson Statistics (2012)
  • Author(s): K. Sasaki, H. Date, T. Tsujiguchi, K. Wakui and A. Itoh
  • Organizer: World Congress on Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing International Convention Center, Beijing(China)
  • Year and Date: 20120526-20120531
• [Presentation] Analysis of Cell Surviving Fraction with Non-Lethal Probability for Radiation Exposure (2012)
  • Author(s): Kosuke Wakui, Kohei Sasaki, Hiroyuki Date
  • Organizer: World Congress on Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing International Convention Center, Beijing(China)
  • Year and Date: 20120526-20120531
• [Presentation] Signal integration of circadian neuronal networks. (2012)
  • Author(s): Sato Honma
  • Organizer: Society for Research on Biological Rhythms Biannual meeting
  • Place of Presentation: Sandestin Resort (USA)
  • Year and Date: 20120519-20120524
• [Presentation] Suprachiasmatic nucleus output couplings. (2012)
  • Author(s): Sato Honma
  • Organizer: Society for Research on Biological Rhythms Biannual meeting
  • Place of Presentation: Sandestin Resort (USA)
  • Year and Date: 20120519-20120524
• [Presentation] 生物時計の発達と睡眠覚醒リズム：時間生物学の小児科学への応用 (2012)
  • Author(s): 本間さと
  • Organizer: 日本小児神経学会
  • Place of Presentation: 札幌ロイトンホテル(北海道)
  • Year and Date: 20120517-20120519
• [Presentation] Design of Treatment Workflow in a Proton Therapy System with Compact Rotating Gantry (2012)
  • Author(s): Seishin Takao, Shinichi Shimizu, Chie Toramatsu, Taeko Matsuura, Hideaki Nihongi, Naoki Miyamoto, Koji Matsuda, Toru Umekawa, Kikuo Umegaki, and Hiroki Shirato
  • Organizer: 51st Annual Meeting of Particle Therapy Co-Operative Group
  • Place of Presentation: COEX（Seoul）
  • Year and Date: 20120514-20120519
• [Presentation] Continuous monitoring of circadian clock’ s tick in the suprachiasmatic neurons. (2012)
  • Author(s): Sato Honma
  • Organizer: International Syposium on Frontiers in Sleep and Biological Rhythms’ Research
  • Place of Presentation: Dokuz Eylul University Izmir (Turkey)
  • Year and Date: 20120430-20120502
• [Presentation] Treatment outcome of radiation therapy for breast cancer: The Hokkaido University Hospital experience (2012)
  • Author(s): Kinoshita R, Shimizu S, Nishioka K, Harada K, Onodera S, Hosoda M, Taguchi K, Takahashi H, Shirato H
  • Organizer: 第71回 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 20120413-20120415
• [Presentation] 胃悪性リンパ腫に対する迎撃照射とマーカー移動の解析 (2012)
  • Author(s): 加藤徳雄、鈴木隆介、井上哲也、安田耕一、鬼丸力也、清水伸一、木村理奈、石川正純、白土博樹
  • Organizer: 第71回 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 20120413-20120413
• [Presentation] Upcoming Dynamic Real-time Tumor-tracking for Lung Cancer: A Preliminary Study of its Validity
  • Author(s): Rie Yamazaki, Seiko Nishioka, Hiroyuki Date, Takao Koike, Hiroki Shirato, Takeshi Nishioka
  • Organizer: Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • Place of Presentation: Sapporo Convention Center(Hokkaido)
• [Presentation] A Mathematical Method for Estimating Optimal Fractionation Regimen in Radiotherapy
  • Author(s): Seishin Takao, Masahiro Mizuta, Hiroyuki Date, Yuriko Komiya, Kenneth L. Sutherland, Rikiya Onimaru, Hiroki Shirato
  • Organizer: Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • Place of Presentation: Sapporo Convention Center(Hokkaido)
• [Presentation] タイミング予測の神経機構
  • Author(s): 田中真樹
  • Organizer: システム神経科学セミナーシリーズ第4回
  • Place of Presentation: 国立精神神経センター神経研究所（東京都）
  • Invited
• [Presentation] タイミング予測の神経機構
  • Author(s): 田中真樹
  • Organizer: 第15回山形めまい研究会
  • Place of Presentation: 山形国際ホテル（山形県）
  • Invited
• [Presentation] 小脳の時間情報処理：行動特性を支配するゲノム基盤と脳機能の解明
  • Author(s): 田中真樹
  • Organizer: 平成24年度 京都大学霊長類研究所共同利用研究会
  • Place of Presentation: 京都大学霊長類研究所（愛知県）
  • Invited
• [Presentation] 自発性サッカードのタイミング制御におけるドパミンの関与
  • Author(s): 國松 淳, 田中真樹
  • Organizer: 第６回生理研Motor Control研究会
  • Place of Presentation: 生理学研究所（愛知県）
• [Presentation] オドボール課題遂行中のサル視床ニューロンの予期的活動
  • Author(s): 松山 圭, 國松 淳, 田中真樹
  • Organizer: 第６回生理研Motor Control研究会
  • Place of Presentation: 生理学研究所（愛知県）
• [Presentation] サル前頭眼野の電気刺激による物体選択の操作．複数の刺激位置を記憶するための神経機構
  • Author(s): 松嶋藻乃, 田中真樹
  • Organizer: 包括脳ワークショップ
  • Place of Presentation: 仙台国際センター（仙台市）
• [Presentation] 線条体ドパミンによる自発的な運動のタイミング調節
  • Author(s): 國松 淳, 田中真樹
  • Organizer: 第92回日本生理学会北海道地方会
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] Saccade target selection determines direction of cerebellar adaptation
  • Author(s): Habtemariam A, 松嶋藻乃, 田中真樹
  • Organizer: 第92回日本生理学会北海道地方会
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] 記憶すべき複数刺激の相対位置により異なる二つの符号化
  • Author(s): 松嶋藻乃,田中真樹
  • Organizer: 第92回日本生理学会北海道地方会
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] 即時的な行動選択に関わる淡蒼球の神経活動
  • Author(s): 吉田篤司, 田中真樹
  • Organizer: 第92回日本生理学会北海道地方会
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] サル視床ニューロンにおける反応性から予測性への活動変化
  • Author(s): 松山 圭, 國松 淳, 田中真樹
  • Organizer: 第92回日本生理学会北海道地方会
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] Long-term follow-up Study about Preventive Effect of H. pylori Eradication for the Incidence of Metachronous Gastric Cancer after Endoscopic Resection of Primary Early Gastric Cancer.
  • Author(s): Kato M, Kikuchi S, Asaka M.
  • Organizer: DDW2012
  • Place of Presentation: Convention Center （USA)
• [Presentation] NSAID/Aspirin induced small intestinal injury.
  • Author(s): Kato M,
  • Organizer: APDW2012
  • Place of Presentation: Queen Sirkit National Convention Center （Bangkok）
  • Invited
• [Presentation] A randomized controlled study for the third-line rescuer therapy after failure of two H. pylori eradication in Japan.
  • Author(s): Kato M, Murakami K, Furuta T.
  • Organizer: XXVth Internationa Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
  • Place of Presentation: The Grand Union Hotel（Ljubljana）
• [Presentation] The identification for high risk group of gastric cancer using serum pepsinogen after successful eradication of H. pylori
  • Author(s): Kato M, Haneda M, Ishigaki S, Suzuki M, Takahashi M, Ono S, Mabe K, Shimizu Y
  • Organizer: UEGW 2012
  • Place of Presentation: Amsterdam RAI（Amsterdam）
• [Presentation] Insertion and fixation of gold markers using new disposable insertion system for Real-Time Tumor-Tracking Radiotherapy against lung cancer
  • Author(s): Naofumi Shinagawa
  • Organizer: World Congress of Bronchology
  • Place of Presentation: Cleveland（USA）
• [Presentation] Insertion and fixation of gold markers using new disposable insertion system for Real-Time Tumor-Tracking Radiotherapy against lung cancer
  • Author(s): Naofumi Shinagawa
  • Organizer: 3rd International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • Place of Presentation: 札幌コンベンションセンター（北海道）
• [Presentation] Clinical outcomes of concurrent chemoradiotherapy using cisplatin and vinorelbine for stage III non-small cell lung cancer. International Conference Center Hiroshima, Japan, July 19th -21st, 2012
  • Author(s): Souda I, Hayakawa K, Ishiyama H, Niibe Y, Komori S, Sekiguchi A, Igawa S, Mitsufuji H, Katagairi M, Masuda N
  • Organizer: The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: 広島国際会議場（広島市）
• [Presentation] Development of fast and high-spatial-resolution 3-dimensional dosimetry equipment for both the narrow beam and the broad beam in proton therapy. (abstract: Int J Radiat Oncol Biol Phys, 84(3, Suppl): S55, 2012)
  • Author(s): Nakamura S, Asai H, Akita S, Aoyama Y, Kamikubo Y, Sugama Y, Takei H, Nishio T, Maruyama K, Hayakawa K
  • Organizer: 54th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Boston Convention and Exhibition Center（USA）
• [Presentation] 肺癌の放射線治療
  • Author(s): 澁谷 景子
  • Organizer: 第47回日本呼吸器学会中国・四国地方会
  • Place of Presentation: 海峡メッセ下関（下関市）
  • Invited
• [Presentation] 肝胆膵
  • Author(s): 澁谷 景子
  • Organizer: JASTRO日本放射線腫瘍学会 第14回放射線腫瘍学夏季セミナー
  • Place of Presentation: 九州大学医学部百年記念講堂（福岡市）
  • Invited
• [Presentation] 放射線治療の最前線
  • Author(s): 澁谷 景子
  • Organizer: 国際膵臓シンポジウム2012 市民公開講座
  • Place of Presentation: 国立京都国際会館アネックスホール（京都市）
  • Invited
• [Presentation] 肺癌の克服に向けて―将来への提言―
  • Author(s): 澁谷 景子
  • Organizer: 第53回日本肺癌学会総会
  • Place of Presentation: ホテルグランヴィア岡山（岡山市）
  • Invited
• [Presentation] 体内時計による全身の時計遺伝子発現リズム調節機構解明へー 光イメージングを用いてのアプローチ
  • Author(s): 浜田俊幸
  • Organizer: 先端的光イメージング研究拠点形成プロジェクト 研究成果報告シンポジウム
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] 動体追跡法による覚醒マウス脳内遺伝子発現の定量解析に関する研究
  • Author(s): 浜田俊幸
  • Organizer: 早稲田大学先進理工学部生理・薬理研究室セミナー
  • Place of Presentation: 早稲田大学（東京都）
  • Invited
• [Presentation] 覚醒マウス嗅球および皮膚における時計遺伝子発現の４Dイメージング
  • Author(s): 浜田俊幸
  • Organizer: 北海道医学大会生理系分科会
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] 原発巣へのFDG集積による非浸潤性非小細胞癌の判定
  • Author(s): 武藤 潤，樋田泰浩，加賀基知三，加藤達哉，大高和人，井上 玲，中田玲子，平野 聡，松居喜郎
  • Organizer: 第29回日本呼吸器外科学会総会
  • Place of Presentation: 秋田県民会館（秋田市）
• [Presentation] 非小細胞肺癌患者におけるSUV補正の有鞘性の検討
  • Author(s): 大高和人,樋田泰浩,長谷龍之介,武藤潤,中田玲子,加賀基知三,松居喜郎
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Book] MT標準臨床検査学「臨床医学総論」II 放射性同位元素検査技術学 第１章 放射線同位元素の物理と計測装置 (2013)
  • Author(s): 伊達 広行
  • Total Pages: 208-219
  • Publisher: 医学書院
• [Book] DOJIN SCIENCE SERIES 02 時間生物学 (2012)
  • Author(s): 本間 さと
  • Total Pages: 55-65
  • Publisher: 科学同人
• [Book] 日本放射線腫瘍学会・日本放射線腫瘍学研究機構・編：臨床放射線腫瘍学-最新知見に基づいた放射線治療の実践- (2012)
  • Author(s): 早川和重（分担）
  • Total Pages: 300－305
  • Publisher: 南江堂，東京
• [Book] 日本放射線腫瘍学会編・放射線治療計画ガイドライン2012年版 (2012)
  • Author(s): 早川和重（分担）
  • Total Pages: 123－128
  • Publisher: 金原出版，東京
• [Book] Computer Simulation and Analysis of Three-Dimensional Tumor Geometry in Radiotherapy, Applied Biological Engineering - Principles and Practice (2012)
  • Author(s): Takao S, Tadano S, Taguchi H, and Shirato H. （分担）
  • Total Pages: 662（うち29-46）
  • Publisher: InTech
• [Remarks] 空間的注意
  • URL: http://bsd.neuroinf.jp/wiki/