Nutritional functions and its organ metabolism network

2011 Fiscal Year Final Research Report

• Project/Area Number: 21300277
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: The University of Tokushima
• Principal Investigator: TAKEDA Eiji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00144973)
• Co-Investigator(Kenkyū-buntansha): TAKETANI Yutaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263825)
• Project Period (FY): 2009 – 2011
• Keywords: 栄養素 / 相互作用 / パラチノース / オレイン酸 / 線維芽細胞増殖因子21(FGF21)

Research Abstract

In this research, it is clarified that synergistic effects of combination of palatinose and oleic acid or sucrose and linolic acid are explained by changes of fatty acid components in various organs and that fibroblast growth factor 21 is an important metabolically protective factor because increased expression is observed in both hunger and satiety stimuli.

Research Products

• [Journal Article] Protective Effects of Dipeptidyl Peptidase-4(DPP-4) Inhibitor against Increased (2011)
  • Author(s): Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y
  • Journal Title: Cell Apoptosis Induced by Dietary Sucrose and Linoleic Acid in Mice with Diabetes. Volume: 286(29) Pages: 25467-25476
  • DOI: DOI:10.1074/jbc.M110.217216
  • Peer Reviewed
• [Journal Article] Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity (2011)
  • Author(s): Taniguchi-Fukatsu A, Yamanaka-Okumura H, Naniwa-Kuroki Y, Nishida Y, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance Volume: 7 Pages: 1-8
  • DOI: DOI:10.1017/s0007114511004156
  • Peer Reviewed
• [Journal Article] Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet (2011)
  • Author(s): Uebanso T, Taketani Y, Yamamoto H, Amo K, Tanaka S, Arai H, Takei Y, Masuda M, Yamanaka-Okumura H, Takeda E
  • Journal Title: J Nutr Biochem
  • DOI: DOI:10.1016/j.jnutbio.2011.03.023
  • Peer Reviewed
• [Journal Article] Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals : Is FGF21 a Nutritional Adaptation Factor? (2011)
  • Author(s): Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E
  • Journal Title: PLoS One Volume: 6(8) Pages: e22976
  • DOI: DOI:10.1371/journal.pone.0022976
  • Peer Reviewed
• [Journal Article] Effects of xylitol on metabolic parameters and visceral fat accumulation (2011)
  • Author(s): Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: J Clin Biochem Nutr Volume: 49(1) Pages: 1-7
  • DOI: DOI:10.3164/jcbn.10-111
  • Peer Reviewed
• [Journal Article] Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice (2011)
  • Author(s): Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E, Terauchi Y
  • Journal Title: Diabetes Volume: 60 Pages: 1246-1257
  • DOI: DOI:10.2337/db10-1338
  • Peer Reviewed
• [Journal Article] Increasing early insulin secretion compensate adequately for hepatic insulin resistance in CCI4-induced cirrhosis rats (2010)
  • Author(s): Arai H, Awane N, Mizuno A, Fukaya M, Sakuma M, Harada N, Kawaura A, Yamamoto H, Okumura H, Taketani Y, Doi T, Takeda E
  • Journal Title: The Journal of Medical Investigation Volume: 57(1-2) Pages: 54-61
  • DOI: 10.2152/jmi.57.54
  • Peer Reviewed
• [Journal Article] Effect of long-term late-evening snack on health-related quality of life in cirrhotic patients (2010)
  • Author(s): Yamanaka-Okumura H, Nakamura T, Miyake H, Takeuchi H, Katayama T, Morine Y, Imura S, Shimada M, Takeda E
  • Journal Title: Hepatology Research Volume: 40(5) Pages: 470-476
  • DOI: DOI:10.111/j.1872-034X.2010.00637.x
  • Peer Reviewed
• [Journal Article] Protective effects of glycoglycerolipids extracted from spinach on 5-fluorouracil induced intestinal mucosal injury (2010)
  • Author(s): Shiota A, Hada T, Baba T, Sato M, Yamanaka-Okumura H, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: J Med Invest Volume: 57(3, 4) Pages: 314-320
  • DOI: 10.2152/jmi.57.314
  • Peer Reviewed
• [Journal Article] Does-dependent Effects of Barley Cooked with White Rice on postprandial Glucose and Desacyl Ghrelin Levels (2009)
  • Author(s): Sakuma M, Yamanaka-Okumura H, Naniwa Y, Matsumoto D, Tsunematsu M, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: J Clin Biochem Nutr Volume: 44(2) Pages: 151-159
  • DOI: 10.3164/jcbn.08-232
  • Peer Reviewed
• [Journal Article] Improvement of Glucose Metabolism in Patients with Impaired Glucose Tolerance or Diabetes by Long-Term Administration of a Palatinose-Based Liquid Formula as a Part of Breakfast (2009)
  • Author(s): Sakuma M, Arai H, Mizuno A, Fukaya M, Matsuura M, Sasaki H, Yamanaka-Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E
  • Journal Title: J Clin Biochem Nutr Volume: 45 Pages: 155-162
  • DOI: 10.3164/jcbn.09-08
  • Peer Reviewed
• [Journal Article] Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways (2009)
  • Author(s): Uebanso T, Taketani Y, Fukaya M, Sato K, Takei Y, Sato T, Sawada N, Amo K, Harada N, Arai H, Yamamoto H, Takeda E
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 297 Pages: E76-E84
  • DOI: DOI:10.1152/ajpendo.00014.2009
  • Peer Reviewed
• [Presentation] 食餌中の糖・脂質の異なる組合せがZucker fattyラットのインスリン感受性と骨格筋の脂肪酸組成に及ぼす影響 (2012)
  • Author(s): 大南博和、阿望幾久子、竹谷豊、佐藤佳瑞智、新井英一、小金井恵、佐々木一、奥村仙示、山本浩範、武田英二
  • Organizer: 第15回日本病態栄養学会
  • Place of Presentation: 京都国際会議場、京都市
  • Year and Date: 20120114-15
• [Presentation] Flavonoid Derivatives Prevent Disuse Muscle Atrophy (2011)
  • Author(s): Mukai R, Kawamura T, Nemoto H, Nikawa T, Yamamoto H, Takeda E, Terao J
  • Organizer: The International Conference on Food Factors 2011
  • Place of Presentation: Taipei International Convention Center,台北、台湾
  • Year and Date: 20111120-23
• [Presentation] ヒトFGF21は絶食・飽食シグナルを感知する栄養代謝の変化に応答する因子である (2011)
  • Author(s): 竹谷豊、上番増喬、大南博和、武田英二
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路夢舞台会議場、兵庫県
  • Year and Date: 20110923-24
• [Presentation] Natto And Viscous Vegetables Improved Insulin Sensitivity, Lipid Metabolism and Oxidative Stress in Impaired Glucose Tolerance Subjects 7^<th> APCCN 2011 (2011)
  • Author(s): Takeda E, Taniguchi-Fukatsu A, Naniwa-Kuroki Y, Nishida Y, Yamamoto H, Taketani Y, Yamanaka-Okumura H
  • Organizer: the Sofitel Centara Grand Bangkok
  • Place of Presentation: バンコク、タイ
  • Year and Date: 20110605-09
• [Presentation] 組織の脂肪酸組成に対して食餌性糖・脂質の組合せが与える影響と、インスリン抵抗性への関連性 (2011)
  • Author(s): 大南博和、阿望幾久子、竹谷豊、上番増喬、佐藤佳瑞智、深谷牧子、新井英一、小金井恵、佐々木一、山本浩範、武田英二
  • Organizer: 第53回日本糖尿病学会学術集会
  • Place of Presentation: 岡山コンベンションセンター、岡山市
  • Year and Date: 20110527-29
• [Presentation] パラチノースとオレイン酸の組合せ食による肥満モデルラットの糖・脂質代謝異常抑制効果 (2010)
  • Author(s): 山本浩範、佐々木一、武田英二
  • Organizer: 第41回日本消化吸収学会総会・第18回日本消化器関連学会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 20101013-16
• [Presentation] IDENTIFICATION OF LABORATORY BIOMARKER REFLECTING NON PROTEIN RESPIRATORY QUOTIENT(NPRQ) IN HEPATIC CIRRHOSIS (2010)
  • Author(s): Yamanaka-Okumura H, Yamauchi R, Urano E, Katayama T, Imura S, Utsunomiya T, Shimada M, Takeda E
  • Organizer: 32nd ESPEN Congress
  • Place of Presentation: the Nice Acropolis Congress and Exhibition Centre,ニース、フランス
  • Year and Date: 20100905-08
• [Presentation] GENE EXPRESSION PROFILING OF HUMAN PERIPHERAL BLOOD IS AFFECTED BY THE DIFFERENCES IN GLYCEMIC AND INSULINEMIC RESPONSES TO FOOD INTAKE (2010)
  • Author(s): Kawakami Y, Yamanaka-Okumura H, Sakuma M, Matsumoto Y, Sato T, Takeda E
  • Organizer: 32nd ESPEN Congress
  • Place of Presentation: the Nice Acropolis Congress and Exhibition Centre,ニース、フランス
  • Year and Date: 20100905-08
• [Presentation] Human FGF21 is Paradoxically Induced by both Fasting and Over-Feeding Signals-Is FGF21 a Nutritional Adaptation Factor?. (2010)
  • Author(s): Uebanso T, Taketani Y, Yamamoto H, Amo K, Arai H, Takei Y, Masuda M, Tanimura A, Yamanaka-Okumura H, Takeda E
  • Organizer: American Diabetes Association(ADA) 70th Annual Scientific Sessions
  • Place of Presentation: Orange Country Convention Center,オーランド、アメリカ合衆国
  • Year and Date: 20100625-29
• [Presentation] The Interaction of Dietary Carbohy drate and Fat on Pancreatic Islet Dysfunction Mediated by Glucolipotoxicity (2010)
  • Author(s): Amou K, Ominami H, Taketani Y, Sato K, Fukaya M, Uebanso T, Arai H, Koganei M, Sasaki H, Yamamoto H, Takeda E
  • Organizer: American Diabetes Association(ADA) 70th Annual Scientific Sessions
  • Place of Presentation: Orange Country Convention Center,オーランド、アメリカ合衆国
  • Year and Date: 20100625-29
• [Presentation] Combined Efects of Dietary Carbohy drate and Fat on Tissue Fatty Acid Composition and Insulin Resistance、American Diabetes Association(ADA) 70th Annual Scientific Sessions (2010)
  • Author(s): Ominami H, Amou K, Taketani Y, Uebanso T, Sato K, Fukaya M, Arai H, Koganei M, Sasaki H, Yamamoto H, Takeda E
  • Organizer: American Diabetes Association(ADA) 70th Annual Scientific Sessions
  • Place of Presentation: Orange Country Convention Center,オーランド、アメリカ合衆国
  • Year and Date: 20100625-29
• [Presentation] Increased. Cell Apoptosis with Multiorgan Glucolopotoxicity by a Combination of Dietary Suger and Fatty Acid and Protectiove Effects of DPP-4 Inhibitor Des-Fluoro-Sitagliptin Against Them (2010)
  • Author(s): Shirakawa J, Takeda E, Terauchi Y
  • Organizer: American Diabetes Association(ADA) 70th Annual Scientific Sessions
  • Place of Presentation: Orange Country Convention Center,オーランド、アメリカ合衆国
  • Year and Date: 20100625-29
• [Presentation] 糖・脂肪毒性の相互作用を介した膵β細胞障害の発症機序の解明 (2010)
  • Author(s): 阿望幾久子、大南博和、竹谷豊、佐藤佳瑞智、深谷牧子、上番増喬、新井英一、小金井恵、佐々木一、山本浩範、武田英二
  • Organizer: 第53回日本糖尿病学会学術集会
  • Place of Presentation: 岡山コンベンションセンター、岡山市
  • Year and Date: 20100527-29
• [Presentation] 肝疾患患者に対するテーラーメイド栄養管理の血液生化学指標についての検討 (2010)
  • Author(s): 奥村仙示、山内利香、浦野恵利、居村暁、宇都宮徹、島田光生、武田英二
  • Organizer: 第33回日本栄養アセスメント研究会
  • Place of Presentation: 千里ライフサイエンスセンター、大阪府
  • Year and Date: 20100514-15
• [Presentation] FGF21はグルコースにより誘導される (2010)
  • Author(s): 上番増喬、竹谷豊、山本浩範、阿望幾久子、新井英一、竹井悠一郎、増田真志、谷村綾子、原田永勝、奥村仙示、武田英二
  • Organizer: 第13回日本病態栄養学会年次学術集会
  • Place of Presentation: 京都国際会議場、京都市
  • Year and Date: 20100109-10
• [Presentation] Hypocaloric Carbohydrate Restricted Diet Improves Fatty Liver and Hypertriglyceridemia in Sucrose-fed Obese Rats via Two Pathways (2009)
  • Author(s): Uebanso T, Taketani Y, Fukaya M, Sato K, Takei Y, Sato T, Sawada N, Amo K, Arai H, Harada N, Yamamoto H, Takeda E
  • Organizer: American Diabetes Association 69th Scientific Sessions
  • Place of Presentation: Memorial Convention Center,ニューオーリンズ、アメリカ合衆国
  • Year and Date: 20090605-09
• [Presentation] 低エネルギー高タンパク食は肥満ラットにおいて2つの経路を介して脂肪肝、高TG血症を改善する (2009)
  • Author(s): 上番増喬、竹谷豊、深谷牧子、佐藤佳瑞智、阿望幾久子、新井英一、奥村仙示、山本浩範、武田英二
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090521-24
• [Book] メタボリックシンドローム、第8章各疾患の栄養管理、キーワードでわかる臨床栄養改訂版栄養で治す!基礎から実践まで (2011)
  • Author(s): 武田英二、池田翔子、香西美奈
  • Publisher: 株式会社羊土社