2011 Fiscal Year Final Research Report
Statistical Analysis of Single Cell Mechanics by Atomic Force Microscopy
| Project/Area Number |
21310079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Koichi 北海道大学, 情報科学研究科, 特任教授 (20125397)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 原子間力顕微鏡 / 多数細胞 / 細胞レオロジー / ナノ計測 / 細胞周期 / 細胞分化 / 細胞診断 / 統計解析 |
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| Research Abstract |
We investigated the number distribution of single cell rheology by atomic force microscopy (AFM) and discuss the statistical data in connection with a modern model of cell rheology such as power-law rheology. (1) The number distribution of single cell rheology was measured as a function of external frequency. (2) The rheological behavior of cells was measured as cells were synchronized using serum starvation. (3) We succeeded to measure the ensemble-and time-averaged cell rheology and found differences between them. (4) We investigated the number distribution of power-law rheology of cells transformed from normal cells to immortalized cells.
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