2014 Fiscal Year Final Research Report
| Project/Area Number |
21370004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Chuo University (2012-2013)
Saitama University (2011)
Nagoya City University (2009-2010) |
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Principal Investigator |
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| Project Period (FY) |
2009-04-01 – 2015-03-31
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| Keywords | 減数分裂 / 細胞周期 / Cdk1 / Cdc25 / Wee1 / 転写因子 |
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| Outline of Final Research Achievements |
In eukaryotes, the cyclin-dependent kinase Cdk1p (Cdc2p) plays a central role in entry into and progression through nuclear division during mitosis and meiosis. Cdk1p is activated during meiotic nuclear divisions by dephosphorylation of its tyrosine-15 residue. The phosphorylation status of this residue is largely determined by the Wee1p kinase and the Cdc25p phosphatase. In fission yeast, the forkhead-type transcription factor Mei4p is essential for entry into the first meiotic nuclear division. We recently identified cdc25+ as an essential target of Mei4p in the control of entry into meiosis I. Here, we show that wee1+ is another important target of Mei4p in the control of entry into meiosis I. The results we obtained suggest that repression of wee1+ expression is primarily owing to Mei4p-mediated transcriptional interference.
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| Free Research Field |
分子生物学
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