2012 Fiscal Year Final Research Report
pH regulation of organelles and its physiological role and molecular mechanism
| Project/Area Number |
21370055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Chugoku Gakuen University (2011-2012)
Osaka University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MITSUI Kaiji 大阪大学, 理学研究科, 助教 (60379279)
NAGAMORI Syushi 大阪大学, 医学研究科, 助教 (90467572)
MATSUSHITA Masafumi 大阪大学, 理学研究科, 助教 (50403100)
OHGAKI Ryuichi 大阪大学, 医学研究科, 助教 (20467525)
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| Project Period (FY) |
2009 – 2012
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| Keywords | エンドサイトーシス / 酵母の NHE / 細胞内局所p H 制御 / 細胞内蛋白質局在化 機構 / 細胞内 pH 調節 Na+/H+ 交換輸送体 / 細胞内小胞型 NHE / 細胞内蛋白質の輸送 |
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| Research Abstract |
Na+/H+ exchangers (NHE. Or Nha) are found in the plasma or endosome membranes for the most cells of living organisms. Cytoplasmic pH is maintained at 7 while intracellular ensodome pH is set at weak acidic pH. NHEs are provided to regulate the cytoplasmic and endosome pH. However, their physiological function is still not clarified. In the present study, we focused on the physiological role of NHE localized at various endosomes and found a novel role in the intracellular protein trafficking.
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[Journal Article] Na+/H+ exchanger isoform 6 (NHE6/ SLC9A6) is involved in clathrin-dependent endocytosis of transferrin2011
Author(s)
Lou, X., Matsushita, M., Numaza, M., Taguchi, Mitsui, K., and Kanazawa, H.
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Journal Title
Am. J. Physiol. Cell Physiol.
Volume: 301
Pages: C1431-1444
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[Journal Article] James1Quantitative proteomic analysis of the adipocyte plasma membrane2011
Author(s)
Matthew J. Prior1, Mark Larance1, Robert T. Lawrence1, Jamie Soul1, SeanHumphrey1, James Burchfield1, Carol Kistler2, Jonathon R. Davey1, Penelope J. La-Borde1, Michael Buckley3, Hiroshi Kanazawa4, Robert G. Parton4, MichaelGuilhaus5 and David E.
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Journal Title
J. Proteome. Res
Volume: 10
Pages: 4970-4982
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