2011 Fiscal Year Final Research Report
Novel roles of adipocytes in the mammary gland development and breast cancer progression, and involvement of adipokines in the roles
| Project/Area Number |
21380177
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KIMURA Kazuhiro 北海道大学, 大学院・獣医学研究科, 教授 (30192561)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMATSU Yoko 北海道大学, 大学院・獣医学研究科, 助教 (90527178)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 乳腺 / 乳癌 / 脂肪細胞 / エストロゲン / プロラクチン / レプチン / HGF / NGF |
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| Research Abstract |
The mammary gland develops in subcutaneous adipose tissue in the post natal period, and adipocytes function as a nursing cell for epithelial cells. With hypertrophy of adipocytes, ductal development of mammary gland in non-pregnant mice was impaired. Hypertrophy of adipocytes also delayed side-branch formation from the duct in the early phase of pregnancy, and acinar formation and its maturation in the mid-and late phase of pregnancy. Hypertrophy of adipocytes caused hyper-leptinemia, and leptin mimicked some effects by hypertrophy of adipocytes both in vivo and in vitro. Therefore, it was suggested that hypertrophy of adipocytes suppressed mammary gland development and leptin partly played a role in the suppression.
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Research Products
(37 results)
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[Journal Article] Implications for C-peptide-cell membrane interaction2012
Author(s)
Ishii, T., Fukano, K., Shimada, K., Kamikawa, A., Okamatsu-Ogura Y., Terao, A., Yoshida, T., Saito, , M and Kimura, K.
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Journal Title
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[Journal Article] Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes2012
Author(s)
Shimada, K., Ohno, Y., Okamatsu-Ogura, Y., Suzuki, M., Kamikawa, A., Terao, A. and Kimura, K
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Journal Title
Peptides
Volume: 34
Pages: 336-342
Peer Reviewed
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[Journal Article] Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation2011
Author(s)
Shimba, S., Ogawa, T., Hitosugi, S., Ichihashi, Y., Nakadaira, Y., Kobayashi, M., Tezuka, M., Kosuge, Y., Ishige, K., Ito, Y., Komiyama, K., Okamatsu-Ogura, Y., Kimura, K. and Saito, M.
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Journal Title
PLoS ONE
Volume: 6
Pages: 6:e25231
Peer Reviewed
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[Journal Article] Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype2010
Author(s)
Sawada, T., Miyoshi, H., Shimada, K., Suzuki, A., Okamatsu, Y., Perfield II, J. W., Kondo, T., Nagai, S., Shimizu, C., Yoshioka, N., Greenberg, A. S., Kimura, K. and Koike, T.
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Journal Title
Peer Reviewed
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[Journal Article] Retinol binding protein 4 in dairy cows : its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum period.2010
Author(s)
Abd Eldaim, M. A., Kamikawa, A., Soliman, M. M., Ahmed, M. M., Okamatsu-Ogura, Y., Terao, A., Miyamoto, T. and Kimura, K.
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Journal Title
J. Dairy Res
Volume: 77
Pages: 27-32
Peer Reviewed
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[Journal Article] Proinsulin C-peptide prevents Type-1 diabetes-induced decrease of renal Na^+-K^+-ATPase α1-subunit in rats.2010
Author(s)
Nordquist, L., Shimada, K., Ishii, T., Furuya, D.T., Kamikawa, A. and Kimura, K.
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Journal Title
Diab. Metab. Res. Rev
Volume: 26
Pages: 193-199
Peer Reviewed
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[Journal Article] Proinsulin Ceptide induces cun N-terminal kinase 1 expression in LEII mouse lung capillary endothelial cells.2009
Author(s)
Furuya, D. T., Ishii, T., Kamikawa, A., Shimada, K., Machado, U.F., Saito, M. and Kimura, K
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Journal Title
Jpn. J. Vet. Res
Volume: 57
Pages: 163-167
Peer Reviewed
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[Journal Article] Diet induced obesity disrupts ductal development in the mammary glands of nonpregnant mice2009
Author(s)
Kamikawa, A., Ichii, O., Yamaji, D., Imao, T., Suzuki, C., Okamatsu-Ogura, Y., Terao, A., Kon, Y. and Kimura, K.
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Journal Title
Dev. Dyn
Volume: 238
Pages: 1092-1099
Peer Reviewed
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