2011 Fiscal Year Final Research Report
Development of methodologies for catalytic decomposition of proteins
| Project/Area Number |
21390031
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OTAKA Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20201973)
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| Co-Investigator(Kenkyū-buntansha) |
SHIGENAGA Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10423394)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ペプチド / ペプチドミメティック / 外部刺激応答型アミノ酸 / ペプチド結合切断 / 標的タンパク質 / ホスファターゼ抵抗性リン酸化アミノ酸 |
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| Research Abstract |
Analysis of protein functions has been indispensable for disclose of unknown cellar phenomena and drug development. Our purpose in this research is the development of methodologies for catalytic decomposition of proteins, which leads to the uncovering protein functions. We have developed a wide variety of chemical devise for elucidation of peptides-and proteins-associated events, including stimulus-responsive amino acids, peptide mimetics, and nonhydrolyzable phosphoamino acids. On the basis of these researches, we have developed several chemical means for the catalytic protein decomposition.
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[Journal Article] Proline cis/ trans-Isomerase Pin1 Regulates Peroxisome Proliferator-activated Receptor gamma Activity through the Direct Binding to the Activation Function-1 Domain2010
Author(s)
Fujimoto, Y.; Shiraki, T.; Horiuchi, Y.; Waku, T.; Shigenaga, A.; Otaka, A.; Ikura, T.; Igarashi, K.; Aimoto, S.; Tate, S.; Morikawa, K
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 3126-3132
DOI
Peer Reviewed
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[Journal Article] Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 12009
Author(s)
Yun, S. M.; Moulaei, T.; Lim, D.; Bang, J. K.; Park, J. E.; Shenoy, S. R.; Liu, F.; Kang, Y. H.; Liao, C. Z.; Soung, N. K.; Lee, S.; Yoon, D. Y.; Lim, Y.; Lee, D. H.; Otaka, A.; Appella, E.; McMahon, J. B.; Nicklaus, M. C.; Burke, T. R.; Yaffe, M. B.; Wlodawer, A.; Lee, K. S.
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Journal Title
Nature Structural & Molecular Biology
Volume: 16
Pages: 876-882
DOI
Peer Reviewed
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