2011 Fiscal Year Final Research Report
Regulation of hepatic lipid metabolism through ileal bile acid-FGF signaling
| Project/Area Number |
21390039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMAZOE Yasushi 東北大学, 大学院・薬学研究科, 教授 (00112699)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINARI Kouichi 東北大学, 大学院・薬学研究科, 准教授 (60343399)
MIYATA Masaaki 東北大学, 大学院・薬学研究科, 助教 (90239418)
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| Project Period (FY) |
2009 – 2011
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| Keywords | FGF15/19 / FXR / 脂質代謝 / 胆汁酸 / 腸内細菌 |
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| Research Abstract |
We studied on the bile acid-mediated regulation of ileal FGF15/19 expression and FGF15/19-mediated regulation of hepatic lipid metabolism. The suppression of enterobacteria-mediated bile acid conversion decreased ileal FGF15 levels resulting in the elevation of hepatic bile acid synthesis. Multiple FXR responsive elements that are involved in the bile acid-mediated transcriptional activation of FGF19 gene we re found in the promoter region. FGF19 treatment decreased hepatic triglyceride and free fatty acid levels in Fxr-null mice.
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