2011 Fiscal Year Final Research Report
Novel strategy for development of suppressive drugs for kidney disease based on inhibition of metabolic production of uremic toxins
| Project/Area Number |
21390048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
SAITO Hideyuki 熊本大学, 医学部附属病院, 教授 (40225727)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Akinobu 熊本大学, 医学部附属病院, 准教授 (00322313)
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| Co-Investigator(Renkei-kenkyūsha) |
NONOGUCHI Hiroshi 兵庫医科大学, 医学部, 准教授 (30218341)
MASUDA Satohiro 京都大学, 医学部附属病院, 講師 (90303825)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 急性腎障害 / 慢性腎不全 / 尿毒症物質 / 腎尿細管 |
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| Research Abstract |
This study was aimed to explore inhibitors of hepatic production of indoxyl sulfate based on uremic toxins which are involved in renal dysfuntion and kidney injury with uremia. By using the screening system for indoxyl sulfate production inhibitors, we found that polyphenolic compounds had potent inhibitory effects on hepatic indoxyl sulfate production. Administration of these polyphenols to rats with acute kidney injury ameliorated the disturbed renal function, suggesting that these approaches could be a useful strategy to develop therapeutic drugs for kidney injuries and/or dieases.
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