2011 Fiscal Year Final Research Report
Arginine methylation in histone code
| Project/Area Number |
21390081
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKASHITA Gyosuk 島根大学, 医学部, 助教 (00397457)
BAN Reiko 島根大学, 医学部, 助教 (40509105)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ヒストン / 翻訳後修飾 / アルギニン残基 / メチル基 / 核内受容体コアクティベータ / がん関連転写制御因子 |
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| Research Abstract |
We identified a cancer-related transcriptional regulator protein NAC1 as a binding partner of histone-arginine methyltransferase PRMT4. The 450-kDa complex also contains nuclear receptor coactivator3NCoA-3. We revealed that PRMT4 regulates functions of hormone nuclear receptor and cancer-related transcription.
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[Journal Article] Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells2012
Author(s)
Inoko A, Matsuyama M, Goto H, Ohmuro-Matsuyama Y, Hayashi Y, Enomoto M, Ibi M, Urano T, Yonemura S, Kiyono T, Izawa I and Inagaki M.
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Journal Title
J. Cell Biol.
Volume: 197
Pages: 391-405
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[Journal Article] pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen2012
Author(s)
Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tokuda N, Tsuchida A, Matsubara T, Hori T, Okajima T, Furukawa K, Urano T and Furukawa K
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 419
Pages: 7-13
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