2011 Fiscal Year Final Research Report
Function and mode of action of Rab family small G proteins in the formation of neuronal network
| Project/Area Number |
21390082
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SASAKI Takuya 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (40241278)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 高次神経機能 / 神経回路 / 神経突起形成 / Rab3 / Rab13 |
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| Research Abstract |
Rab family small G proteins serve as molecular switches in the regulation of vesicular trafficking. In this study, we focus on the role and mode of action of Rab3A, Rab13, and their related proteins in the formation of neuronal network. As to Rab3A, we found using the knockout mice that Rabconnectin, the Rab3A-related protein, is involved in neuronal function, probably through formation of synaptic organization. We also found that the Rab13-JRAB system regulates the reorganization of actin cytoskeleton during neurite extension in PC12 cells. Our results suggest that this system may simultaneously coordinate vesicle transport and actin cytoskeletal reorganization in the neuronal network
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Author(s)
Withanage, K., Nakagawa, K., Ikeda, M., Kurihara, H., Kudo, T., Yang, Z., Sakane, A., Sasaki, T., Hata, Y.
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J. Biochem
Volume: (in press)
DOI
Peer Reviewed
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Author(s)
Tabata, K., Matsunaga, K., Sakane, A., Sasaki, T., Noda, T. and Yoshimori, T.
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Mol. Biol. Cell
Volume: 21(23)
Pages: 4162-4173
DOI
Peer Reviewed
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[Journal Article] APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle2009
Author(s)
Szodorai, A., Kuan, Y-H., Hunzelmann, S., Engel, U., Sakane, A., Sasaki, T., Takai Y., Kirsch, J., Muller, U., Beyreuther, K., Brady, S., Morfini, G. and Kins, S.
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Journal Title
J. Neurosci
Volume: 29(46)
Pages: 14534-14544
DOI
Peer Reviewed
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