2012 Fiscal Year Final Research Report
Elucidation of interaction between malaria parasites and salivary glands using transgenic mosquitoes
| Project/Area Number |
21390126
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Kanazawa University (2010-2012)
Jichi Medical University (2009) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2012
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| Keywords | ハマダラカ / マラリア / トランスジェニシス / 唾液腺 / スポロゾイト |
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| Research Abstract |
We have successfully expressed vaccine antigens in the salivary glands of anopheline mosquitoes using the salivary gland-specific promoter. We observed that the transgenic mosquitoes released saliva containing the vaccine antigen through their proboscis. We made another transgenic mosquito expressing anti-malaria antibody in the salivary glands. The transgenic mosquito strongly impaired malaria transmission from mosquito to host.
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[Journal Article] Novel prophylactic vaccine using a prime-boost method and hemagglutinating virus of Japan-envelope against tuberculosis2011
Author(s)
Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Nishimatsu S, Sekine Y, Inoue Y, McMurray DN, Sakatani M.
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Journal Title
Clin Dev Immunol 2011
Pages: 1-11
DOI
Peer Reviewed
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[Journal Article] Development of therapeutic and prophylactic vaccine against Tuberculosis using monkey and transgenic mice models2011
Author(s)
Kita Y, Okada M, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Kishigami C, Nishimatsu S, Sekine Y, Takamori Y, McMurray DN, Cruz EC, Tan EV, Abalos RM, Burgos JA, Saunderson P, Sakatani M.
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Journal Title
Hum Vaccin
Volume: 7
Pages: 108-114
DOI
Peer Reviewed
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[Journal Article] Novel prophylactic and therapeutic vaccine against tuberculosis.2009
Author(s)
Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida1 S, Nishida Y, Nakatani H, Takao K, Kishigami C, Inoue Y, Matsumoto M, McMurray DN, Dela Cruz EC, Tan EV, Abalos RM, Burgos JA, Saunderson P, Sakatani M.
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Journal Title
Vaccine
Volume: 27
Pages: 3267-70
Peer Reviewed
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[Presentation] Protective efficacy of baculovirus dual expression system that displays the Plasmodium falciparum circumsporozoite protein in a murine infection model.2013
Author(s)
Iyori M, Nakaya H, Inagaki K, YamamotoD, Kawasaki M, Kwak K, Mizukoshi M, Goto Y, Matsuoka H, Matsumoto M, Yoshida S.
Organizer
Keystone Symposia A8 Malaria
Place of Presentation
GW Marriot (USA)
Year and Date
2013-01-22
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