The effects of"Preemptive Infection Control" in critical care center

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390163
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical sociology
• Research Institution: Nagasaki University (2011); Osaka University (2009-2010)
• Principal Investigator: TASAKI Osamu 長崎大学, 病院, 教授 (90346221)
• Co-Investigator(Kenkyū-buntansha): SUGIMOTO Hisashi 大阪大学, 名誉教授 (90127241) ; SHIMAZU Takeshi 大阪大学, 医学系研究科, 教授 (50196474) ; TOMONO Kazunori 大阪大学, 医学系研究科, 教授 (40202204) ; KUWAGATA Yasuyuki 大阪大学, 医学系研究科, 准教授 (50273678) ; OGURA Hiroshi 大阪大学, 医学系研究科, 講師 (70301265) ; SHIOZAKI Tadahiko 大阪大学, 医学系研究科, 助教 (60278687) ; MATSUMOTO Naoya 大阪大学, 医学部附属病院, 助教 (50359808) ; IRISAWA Taro 大阪大学, 医学部附属病院, 特任助教 (50379202) ; MUROYA Takashi 大阪大学, 医学部附属病院, 医員 (20528434) ; HIROSE Tomoya 大阪大学, 医学部附属病院, 医員 (70597509)
• Project Period (FY): 2009 – 2011
• Keywords: 感染制御学

Research Abstract

After introduction of preemptive contact precautions for intubated patients in critical care center, incidence of healthcare-associated MRSA infection (HA-MRSA infection) significantly decreased in not only intubated patients, but also all the patients. Risk factors for HA-MRSA infection in critical care center were intubation, open wound, antibiotic treatments, and use of steroids, all within 24hrs of admission. Neutrophil extracellular traps(NETs) were promptly expressed in sputum after respiratory infection, and decreased as infection subsided. NETs were expressed in blood in response to not only infection but also noninfectious severe insults. It is necessary to clarify clinical significance of NETs.

Research Products

• [Journal Article] Dynamic changes in the expression of neutrophil extracellular traps in acute respiratory infections (2012)
  • Author(s): Hirose T, Hamaguchi S, Matsumoto N, Irisawa T, Seki M, Tasaki O, Hosotsubo H, Tomono K, Shimazu T
  • Journal Title: Am J Respir Crit Care Med Volume: 15;185(10) Pages: 1130-1131
  • Peer Reviewed
• [Journal Article] 感染症におけるチーム医療 (2012)
  • Author(s): 山野修平、田崎修
  • Journal Title: 救急医学 Volume: 36巻 Pages: 677-680
• [Journal Article] Assessment of risk factors related to healthcare-associated methicillin-resistant Staphylococcus aureus infection at patient admission to an intensive care unit in Japan (2011)
  • Author(s): Yamakawa K, Tasaki O, Fukuyama M, Kitayama J, Matsuda H, Nakamori Y, Fujimi S, Ogura H, Kuwagata Y, Hamasaki T, Shimazu T
  • Journal Title: BMC Infect Dis Volume: 11 Pages: 303
  • DOI: doi: 10.1186/1471-2334-11-303.
  • Peer Reviewed
• [Journal Article] Pre-emptive contact precautions for intubated patients reduced healthcare-associated meticillin-resistant Staphylococcus aureus transmission and infection in an intensive care unit (2011)
  • Author(s): Matsushima A, Tasaki O, Tomono K, Ogura H, Kuwagata Y, Sugimoto H, Hamasaki T
  • Journal Title: J Hosp Infect Volume: 78(2) Pages: 97-101
  • DOI: doi: 10.1016/j.jhin.2011.02.010.
  • Peer Reviewed
• [Journal Article] ウイルス感染症(サイトメガロウイルス・単純ヘルペス) (2011)
  • Author(s): 山野修平、松本直也、田崎修
  • Journal Title: 救急医学 Volume: 35巻 Pages: 1444-1448
• [Journal Article] Identification of Neutrophil Extracellular Traps in the Blood of Patients with Systemic Inflammatory Response Syndrome
  • Author(s): S HAMAGUCHI, T HIROSE, Y AKEDA, N MATSUMOTO, T IRISAWA, M SEKI, H HOSOTSUBO, O TASAKI, K OISHI, T SHIMAZU, K TOMONO
  • Journal Title: The Journal of International Medical Research Volume: (in press)
  • Peer Reviewed
• [Presentation] 侵襲に対する生体反応としてのNETs(Neutrophil Extracellular Traps) (2012)
  • Author(s): 廣瀬智也、濱口重人、入澤太郎、松本直也、関雅文、田崎修、山本絋司、朝野和典、嶋津岳士
  • Organizer: 日本救急医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-13
• [Presentation] Quantitative analysis of dynamic changes in the expression of neutrophil extracellular traps in acute respiratory infections (2012)
  • Author(s): Hirose T, Hamaguchi S, Matsumoto N, Irisawa T, Seki M, Tasaki O, Hosotsubo H, Tomono K, Shimazu T
  • Organizer: 71^<st> Annual Meeting of the American Association for the Surgery of Trauma and Clinical Congress of Acute Care Surgery
  • Place of Presentation: Hawaii
  • Year and Date: 2012-09-12
• [Presentation] 軟部組織感染症の膿瘍腔ドレナージによる膿中NETs(Neutrophil Extracellular Traps)の動的変化 (2011)
  • Author(s): 入澤太郎、濱口重人、廣瀬智也、松本直也、田崎修、小倉裕司、鍬方安行、朝野和典、嶋津岳士
  • Organizer: 日本救急医学総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-20
• [Presentation] 急性呼吸器感染症における喀痰中NETs(Neutrophil Extracellular Traps)の動的変化 (2011)
  • Author(s): 廣瀬智也、濱口重人、入澤太郎、松本直也、田崎修、細坪秀夫、小倉裕司、朝野和典、嶋津岳士
  • Place of Presentation: 東京
  • Year and Date: 2011-11-20
• [Presentation] Risk factors and prediction model for MRSA nosocomial infection in intensive care unit (2010)
  • Author(s): Yamakawa K, Tasaki O, Kitayama J, Nakamori Y, Fujimi S, Ogura H, Kuwagata Y, Hamasaki T
  • Organizer: 69^<th> Annual Meeting of the American Association for the Surgery of Trauma
  • Place of Presentation: Boston, MA.
  • Year and Date: 2010-09-22
• [Presentation] The effect of preemptive contact precaution for intubated patients on the nosocomial infection of MRSA in the intensive care unit (2010)
  • Author(s): Muroya T, Tasaki O, Irisawa T, Shiozaki T, Ogura H, Kuwagata Y, Tomono K, Hamasaki T
  • Organizer: Society of Critical Care Medicine 39^<th> Critical Care Congress
  • Place of Presentation: Miami, Florida
  • Year and Date: 2010-01-09
• [Presentation] MRSAに対するフィトンチッド(F118)の効果に関する検討 (2009)
  • Author(s): 室谷卓、田崎修、朝野和典
  • Organizer: 第83回日本感染症学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-24