2010 Fiscal Year Final Research Report
Establishment of molecular pathological diagnosis of lung and esophageal cancers : Detection of precancerous region and early stage cancer and evaluation of their malignant level.
| Project/Area Number |
21390178
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shiga University of Medical Science (2010-2011)
The University of Tokyo (2009) |
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Principal Investigator |
DAIGO Yataro 滋賀医科大学, 医学部, 特任教授 (30345029)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 病態診断 / 個別化医療 |
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| Research Abstract |
To establish integrated molecular pathological diagnosis system of lung and esophageal cancers applicable as prevention and early cancer detection biomarkers and molecular therapies, we performed gene expression profile analysis of archived lung and esophageal carcinomas. Through a subsequent systematic approach using tissue microarray covering hundreds of clinical cancers as well as proteomics approach, we have identified a set of molecules that are potentially promising candidates for the development of novel serum and/or prognostic biomarkers for lung and esophageal cancers. By combining these markers, we constructed new cancer diagnosis system.
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Research Products
(31 results)
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[Journal Article] Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway2011
Author(s)
Toyokawa G, Cho HS, Masuda K, Yamane Y, Yoshimatsu M, Hayami S, Takawa M, Iwai Y, Daigo Y, Tsuchiya E, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BA, Nakamura Y, Hamamoto R
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Journal Title
Neoplasia
Volume: 13
Pages: 887-898
Peer Reviewed
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[Journal Article] A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T-lymphocytes reactive to tumor cells2011
Author(s)
Tomita Y, Imai K, Senju S, Irie A, Inoue M, Hayashida Y, Shiraishi K, Mori T, Daigo Y, Tsunoda T, Ito T, Nomori H, Nakamura Y, Kohrogi H, Nishimura Y
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Journal Title
Cancer Sci
Volume: 102
Pages: 697-705
DOI
Peer Reviewed
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[Journal Article] Identification of Epstein-Barr Virus-Induced Gene 3 as a Novel Serum and Tissue Biomarker and a Therapeutic Target for Lung Cancer2011
Author(s)
Nishino R, Takano A, Oshita H, Ishikawa N, Akiyama H, Ito H, Nakayama H, Miyagi Y, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
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Journal Title
Clin Cancer Res
Volume: 17
Pages: 6272-6282
Peer Reviewed
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[Journal Article] Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer2011
Author(s)
Toyokawa G, Masuda K, Daigo Y, Cho HS, Yoshimatsu M, Takawa M, Hayami S, Maejima K, Chino M, Field HI, Neal DE, Tsuchiya E, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R.
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Journal Title
Mol Cancer
Volume: 10
Pages: 65
Peer Reviewed
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[Journal Article] Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker2011
Author(s)
Takawa M, Masuda K, Kunizaki M, Daigo Y, Takagi K, Iwai Y, Cho HS, Toyokawa G, Yamane Y, Maejima K, Field HI, Kobayashi T, Akasu T, Sugiyama M, Tsuchiya E, Atomi Y, Ponder BA, Nakamura Y, Hamamoto R.
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Journal Title
Cancer Sci
Volume: 102
Pages: 1298-1305
DOI
Peer Reviewed
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[Journal Article] A comprehensive peptidome profiling technology for the identification of early detection biomarkers for lung adenocarcinoma2011
Author(s)
Ueda K, Saichi N, Takami S, Kang D, Toyama A, Daigo Y, Ishikawa N, Kohno N, Tamura K, Shuin T, Nakayama M, Sato TA, Nakamura Y, Nakagawa H.
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Journal Title
PLoS One
Volume: 6
Pages: e18567
Peer Reviewed
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[Journal Article] The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G(1)/S transition in cancer cells via transcriptional regulation of the HOXA1 gene2010
Author(s)
Cho HS, Toyokawa G, Daigo Y, Hayami S, Masuda K, Ikawa N, Yamane Y, Maejima K, Tsunoda T, Field HI, Kelly JD, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R.
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Journal Title
Peer Reviewed
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[Journal Article] Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations2010
Author(s)
Miki D, Kubo M, Takahashi A, Yoon KA, Kim J, Lee GK, Zo JI, Lee JS, Hosono N, Morizono T, Tsunoda T, Kamatani N, Chayama K, Takahashi T, Inazawa J, Nakamura Y, Daigo Y.
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Journal Title
Nature Genetics
Volume: 42
Pages: 893-896
Peer Reviewed
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[Journal Article] Development of serum glycoproteomic profiling technique ; simultaneous identification of glycosylation sites and site-specific quantification of glycan structure changes2010
Author(s)
Ueda K, Takami S, Saichi N, Daigo Y, Ishikawa N, Kohno N, Katsumata M, Yamane A, Ota M, Sato TA, Nakamura Y, Nakagawa H.
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Journal Title
Mol Cell Proteomics
Volume: 9
Pages: 1819-1828
Peer Reviewed
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[Journal Article] Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy2010
Author(s)
Sato N, Yamabuki T, Takano A, Koinuma J, Aragaki M, Masuda K, Ishikawa N, Kohno N, Ito H, Miyamoto M, Nakayama H, Miyagi Y, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y.
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Journal Title
Cancer Res
Volume: 70
Pages: 5326-5336
Peer Reviewed
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