2011 Fiscal Year Final Research Report
Elucidation of roles of essential trace metals in higher nervous activity
| Project/Area Number |
21390185
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAITO Takeshi 北海道大学, 大学院・保健科学研究院, 教授 (40153811)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 微量金属 / 金属イオン膜輸送蛋白 / 中枢神経系 / 神経伝達物質 / 老化 |
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| Research Abstract |
The aim of this study is to elucidate roles of trace elements, metal transporters and metallochaperone in the central nervous system. Our results indicate that reduction of Cu transporter Ctr1 but not MT induction is the primary cause of the inhibition of Cu absorption by excessive intake of Zn. Declines of syntheses of catecholamines and zinc concentrations were observed in the cerebral cortex of SAMP10 with aging. Cu-polyphenol induces apoptosis via CCS-XIAP degradation induced by incorporated Cu in PC12 cells
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[Journal Article] Comparison of general water quality of rivers in Indonesia and Japan2009
Author(s)
Kido, M., Yustiawati, Syawal, MS, Sulastri, Hosokawa, T., Tanaka, S., Saito, T., Iwakuma, T., Kurasaki, M.
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Journal Title
Environmental Monitoring and Assessment
Volume: 156
Pages: 317-329
Peer Reviewed
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