2011 Fiscal Year Final Research Report
Basic Research on the Treatment of Cardiovasular Disease by Regulating Aging Signals
| Project/Area Number |
21390237
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
MINAMINO Tohru 千葉大学, 大学院・医学研究院, 講師 (90328063)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子心臓病態学 / 老化 |
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| Research Abstract |
he incidence and the prevalence of diabetes, heart failure, coronary heart disease and hypertension increase with advancing age. However, the molecular mechanisms underlying the increased risk of such diseases that is conferred by aging remain unclear. In the present study, we demonstrated that cellular aging signals contribute to the pathogenesis of cardiovascular disease.
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Research Products
(25 results)
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[Journal Article] Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice2012
Author(s)
Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I
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Journal Title
Hypertension
Volume: 59
Pages: 627-633
DOI
Peer Reviewed
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[Journal Article] p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure2012
Author(s)
Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T
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Journal Title
Cell Metab
Volume: 15
Pages: 51-64
DOI
Peer Reviewed
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[Journal Article] Role of JAGGED1 in arterial lesions after vascular injury2011
Author(s)
Wu X, Zou Y, Zhou Q, Huang L, Gong H, Sun A, Tateno K, Katsube K, Radtke F, Ge J, Minamino T, Komuro I
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 31
Pages: 2000-2006
Peer Reviewed
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[Journal Article] Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy2010
Author(s)
Toko H, Takahashi H, Kayama Y, Oka T, Minamino T, Okada S, Morimoto S, Zhan DY, Terasaki F, Anderson ME, Inoue M, Yao A, Nagai R, Kitaura Y, Sasaguri T, Komuro I
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Journal Title
Circulation
Volume: 122
Pages: 891-899
Peer Reviewed
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[Journal Article] Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury2010
Author(s)
Naito AT, Okada S, Minamino T, Iwanaga K, Liu M, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I
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Journal Title
Circ Res
Volume: 106
Pages: 1692-1702
DOI
Peer Reviewed
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[Journal Article] Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload2010
Author(s)
Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED Komuro I
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Journal Title
J Clin Invest
Volume: 120
Pages: 1506-1514
DOI
Peer Reviewed
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[Journal Article] Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis2010
Author(s)
Moriya J, Minamino T, Tateno K, Okada S, Uemura A, Shimizu I, Yokoyama M, Nojima A, Okada M, Koga H, Komuro I
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Journal Title
Circ. Res
Volume: 106
Pages: 391-398
DOI
Peer Reviewed
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[Journal Article] A crucial role for adipose tissue p53 in the regulation of insulin resistance2009
Author(s)
Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I
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Journal Title
Nat. Med
Volume: 15
Pages: 1082-1087
DOI
Peer Reviewed
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[Journal Article] Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure2009
Author(s)
Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I, Takahashi H, Okada S, Tateno K, Moriya J, Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H Komuro I
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Journal Title
J. Exp. Med
Volume: 206
Pages: 1565-1574
DOI
Peer Reviewed
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