Regulation of cell-metabolism by cardiovascular hormones and the comprehensive application to metabolic syndrome.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390286
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Keio University
• Principal Investigator: ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
• Co-Investigator(Kenkyū-buntansha): NAKAE Jun 慶應義塾大学, 医学部, 特任准教授 (00344573) ; WATANABE Mitsuhiro 慶應義塾大学, 医学部, 特任准教授 (10450842) ; SONE Masakatsu 京都大学, 大学院・医学研究科, 助教 (40437207)
• Research Collaborator: ICHIHARA Atsuhiro 東京女子医科大学, 医学部高血圧内分泌内科, 主任教授 (60203105) ; SASAMURA Hiroyuki 慶應義塾大学, 医学部, 特任准教授 (00235293) ; SHIBATA Hirotaka 慶應義塾大学, 医学部, 専任講師 (20245484) ; WAKINO Shu 慶應義塾大学, 医学部, 専任講師 (50265823) ; MIYASHITA Kazutoshi 慶應義塾大学, 医学部, 特任講師 (50378759)
• Project Period (FY): 2009 – 2011
• Keywords: 内分泌学 / 抗加齢医学 / 細胞代謝 / 心血管ホルモン / メタボリックシンドローム / FOXO1 / 胆汁酸 / iPS細胞

Research Abstract

Cardiovascular hormones control cytoskeletal structure in vascular smooth muscle cells and regulate vascular tonus. The present study revealed the regulation of cell-metabolism by cardiovascular hormones via modulation of intracellular organelles. The findings suggest comprehensive application of vascular hormones from the metabolic syndrome to cardiovascular diseases.

Research Products

• [Journal Article] Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor(FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure (2011)
  • Author(s): Watanabe M, Horai Y, Houten SM, Morimoto K, Sugizaki T, Arita E, Mataki C, Sato H, Tanigawara Y, Schoonjans K, H Itoh
  • Journal Title: J Bio Chem Volume: 286(30) Pages: 26913-26920
  • Peer Reviewed
• [Journal Article] (Pro) renin receptor is essential for normal podocyte structure and function (2011)
  • Author(s): Oshima Y, Kinouchi K, Ichihara A, Sakoda M, Kurauchi-Mito A, Bokuda K, Narita T, Kurosawa H, Ge-Hong Sun-Wada, Wada Y, Yamada T, Takemoto M, Moin A. Saleem, Susan E. Quaggin, H Itoh
  • Journal Title: Journal of the American Society of Nephrology Volume: 22(12) Pages: 2203-12
  • Peer Reviewed
• [Journal Article] Rho/Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch (2011)
  • Author(s): Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, H Itoh
  • Journal Title: Sci Signal Volume: 4(157) Pages: 3
  • Peer Reviewed
• [Journal Article] The(Pro) rennin Receptor/ATP6AP2 is Essential for Vascuolar H+-ATPase Assembly in Murine Cardiomyocytes (2010)
  • Author(s): K Kinouchi, A Ichihara, M Sano, Ge-Hong Sun-Wada, Y Wada, A Kurauchi-Mito, K Bokuda, T Narita, Y Oshima, M Sakoda, Y Tamai, H Sato, K Fukuda, H Itoh
  • Journal Title: Circ Res Volume: 107 Pages: 30-34
  • Peer Reviewed
• [Journal Article] Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function (2010)
  • Author(s): K. Hasegawa, S Wakino, K Yoshioka, S Tatematsu, Y Hara, H Minakuchi, K Sueyasu, N Washida, H Tokuyama, M Tzukerman, K Skorecki, K Hayashi, H Itoh
  • Journal Title: J Biol Chem Volume: 285(17) Pages: 13045-13056
  • Peer Reviewed
• [Journal Article] Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells (2010)
  • Author(s): Homma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka M, Fukunaga Y, Tamura N, H Itoh, Yamanaka S, Nakao K
  • Journal Title: Atherosclerosis Volume: 212(1) Pages: 42-7
  • Peer Reviewed
• [Journal Article] Induction and isolation of vascular cells from human induced pluripotent stem cells-brief report (2009)
  • Author(s): Taura D, Sone M, Homma K, Oyamada N, Takahashi K, Tamura N, Yamanaka S, Nakao K
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 29(7) Pages: 1100-3
  • Peer Reviewed
• [Journal Article] Pulse treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension (2009)
  • Author(s): K. Ishiguro, K. Hayashi, H. Sasamura, Y. Sakamaki, H Itoh
  • Journal Title: Hypertension Volume: 53 Pages: 83-89
  • Peer Reviewed
• [Journal Article] Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity (2009)
  • Author(s): Miyashita K, Itoh H, Tsujimoto H, Tamura N, Fukunaga Y, Sone M, Yamahara K, Taura D, Inuzuka M, Sonoyama T, Nakao K
  • Journal Title: Diabetes Volume: 58(12) Pages: 2880-92
  • Peer Reviewed
• [Presentation] 高血圧の成因、病態、治療に関するパラダイムシフト細胞内小器官とアンジオテンシン細胞内代謝モデュレーターとしての意義 (2011)
  • Author(s): 伊藤裕
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-11-25
• [Book] 最新内分泌代謝学高血圧・血管と内分泌総論 (2012)
  • Author(s): 宮下和季、伊藤裕
  • Publisher: 診断と治療社(印刷中)
• [Remarks]
  • URL: http://www.keio-emn.jp/
• [Patent(Industrial Property Rights)] 慢性腎臓病判定用血清マーカーおよびその検出方法、装置 (2009)
  • Inventor(s): 篠村裕之、林香、伊藤裕、末松誠、曽我朋義
  • Industrial Property Rights Holder: 篠村裕之、林香、伊藤裕、末松誠、曽我朋義
  • Industrial Property Number: 特願、2009-206717号
  • Filing Date: 2009-08-17