2011 Fiscal Year Final Research Report
Molecular mechanism of altered cannabinoid signaling in the pathophysiology of schizophrenia
| Project/Area Number |
21390332
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kazuo 理化学研究所, 分子精神科学研究チーム, 副チームリーダー (10322695)
TODA Shigenobu 金沢大学, 附属病院, 講師 (00323006)
YOSHIHARA Toru 金沢大学, 子どものこころの発達研究センター, 特任助教 (00401935)
NISHIUCHI Takumi 金沢大学, 学際科学実験センター, 准教授 (20334790)
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| Co-Investigator(Renkei-kenkyūsha) |
GEORGIEV Danko 金沢大学, 医学系, 博士研究員 (90532193)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 精神薬理学 / マリファナ / 死後脳 |
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| Research Abstract |
In the neocortex of juvenile mice that received chronic injections of a endocannabinoid receptor agonist, we failed to replicate expression changes of certain GABA-related genes that were observed in schizophrenia. However, juvenile monkeys chronically exposed to tetrahydrocannabinol, the main psychoactive constituent of marijuana, expression levels of KCNS3, which encodes PV neuron-specific potassium channel subunit Kv9. 3, were significantly decreased in the prefrontal cortex(PFC). KCNS3 mRNA levels were also decreased in the PFC of subjects with schizophrenia.
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[Journal Article] A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population2011
Author(s)
Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N
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Journal Title
PLoS One
Volume: 6(12)
Pages: e28929
Peer Reviewed
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