2012 Fiscal Year Final Research Report
Development of hybrid therapy of myocardial regenerative medicine and ventricular assist circulation to improve prognosis of heart transplant candidate
| Project/Area Number |
21390398
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TAKEWA Yoshiaki 独立行政法人国立循環器病研究センター, 研究所, 室長 (20332405)
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| Co-Investigator(Kenkyū-buntansha) |
TAENAKA Yoshiyuki 独立行政法人国立循環器病研究センター, 研究所, 副所長 (00142183)
TATSUMI Eisuke 独立行政法人国立循環器病研究センター, 研究所, 部長 (00216996)
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| Co-Investigator(Renkei-kenkyūsha) |
HONMA Akihiko 独立行政法人国立循環器病研究センター, 研究所, 室長 (20287428)
SUMIKURA Hirohito 独立行政法人国立循環器病研究センター, 研究所, 研究員 (20433998)
OHNUMA Kentarou 独立行政法人国立循環器病研究センター, 研究所, 研究員 (50527992)
HANADA Shigeru 独立行政法人国立循環器病研究センター, 研究所, 研究員 (90514547)
KAKUTA Yukihide 独立行政法人国立循環器病研究センター, 研究所, 研究員 (30443485)
FUJII Yutaka 独立行政法人国立循環器病研究センター, 研究所, 研究員 (20589303)
TAKAKI Miyako 奈良県立医科大学, 医学部, 教授 (00033358)
MIZUGUCHI Hiroyuki 大阪大学, 薬学研究科, 教授 (50311387)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 心臓大血管外科学 |
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| Research Abstract |
We created a heart failure model of large animals (adult goats), conducted a continuous flow left ventricular assist circulation, transferred SERCA2a gene, which can increase the myocardial contractility, and investigated whether this hybrid therapy could improve and recover the cardiac function. In terms of assist circulation, a synchronized alteration of rotational speed of a continuous flow pump was effective to accelerate the myocardial recovery. Additional gene therapy could increase the myocardial contractility. The synergistic effect of ventricular assist and myocardial regenerative medicine showed the potential to improve prognosis of heart failure patients such as heart transplant candidates
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[Journal Article] Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models.2013
Author(s)
Umeki A, Nishimura T, Takewa Y, Ando M, Arakawa M, Kishimoto Y, Tsukiya T, Mizuno T, Kyo S, Ono M, Taenaka Y, Tatsumi E.
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Journal Title
J Artif Organs
Volume: (Epub のみ頁未定)
Peer Reviewed
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[Journal Article] Change of coronary flow by continuous-flow left ventricular assist device with cardiac beat synchronizing system (native heart load control system) in acute ischemic heart failure model.2012
Author(s)
Umeki A, Nishimura T, Ando M, Takewa Y, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E.
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Journal Title
Circ J
Volume: 77
Pages: 995-1000
DOI
Peer Reviewed
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[Journal Article] Alteration of LV end-diastolic volume by controlling the power of the continuous-flow LVAD, so it is synchronized with cardiac beat : development of a native heart load control system (NHLCS).2012
Author(s)
Umeki A, NishimuraT, Ando M, Takewa Y, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E.
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Journal Title
J Artif Organs
Volume: 15(2)
Pages: 128-133
DOI
Peer Reviewed
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[Journal Article] In vivo myocardial distribution of multipotent progenitor cells following intracoronary delivery in a swine model of myocardial infarction.2009
Author(s)
Ly HQ, Hoshino K, Pomerantseva I, Kawase Y, Yoneyama R, Takewa Y, Fortier A, Gibbs-Strauss SL, Vooght C, Frangioni JV, Hajjar RJ.
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Journal Title
Eur Heart J.
Volume: 30(23)
Pages: 2861-2868
DOI
Peer Reviewed
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[Presentation] Optimization of the coronary flow by a novel cardiac cycle-synchronized rotation control model in a continuous-flow LVAD in chronic heart failure model.2012
Author(s)
Arakawa M, Takewa Y, Nishimura T, Umeki A, Ando M, Kishimoto Y, Mizuno T, Tsukiya T, Kyo S, Adachi H, Tatsumi E
Organizer
European Society for Artificial Organs
Place of Presentation
Rostock (Germany)
Year and Date
20120926-20120929
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[Presentation] The continuous flow LVAD with native heart load control system (NHLCS) for bridge to recovery could control the coronary flow and myocardial oxygen consumption in acute heart failure model.2011
Author(s)
Nishimura T, Umeki A, Takewa Y, Ando M, Mizuno T, Tsukiya T, Yamazaki K, Ono M, Kyo S, Taenaka Y, Tatsumi E.
Organizer
Joint ESAO-IFAO Congress
Place of Presentation
Porto (Portugal)
Year and Date
20111009-20111012
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[Presentation] The change of coronary flow by controlling the power of continuous-flow left ventricular assist device in acute heart failure : Counterpulse drive mode can increase the coronary flow.2011
Author(s)
Umeki A, Takewa Y, Nishimura T, Ando M, Mizuno T, Tsukiya T, Ono M, Kyo S, Yamazaki K, Taenaka Y, Tatsumi E.
Organizer
American Society for Artificial Internal Organs
Place of Presentation
Washington D.C. (USA)
Year and Date
20110610-20110612
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[Presentation] The continuous-flow LVAD with native heart load control system(NHLCS) for bridge to recovery could control myocardial consumption of oxygen in acute heart failure model.2011
Author(s)
Nishimura T, Umeki A, Takewa Y, Ando M, Tsukiya T, Mizuno T, Kyo S, Ono M, Yamazaki K, Taenaka Y, Tatsumi E.
Organizer
American Society for Artificial Internal Organs
Place of Presentation
Washington D.C. (USA)
Year and Date
20110610-20110612
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