2011 Fiscal Year Final Research Report
Detection of Circulating Endothelial Cells in Severe Sepsis
| Project/Area Number |
21390482
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
KOIKE Kaoru 京都大学, 医学研究科, 教授 (10267164)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Naoyuki 名古屋大学, 医学研究科, 教授 (50332466)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 敗血症 / 遊離型血管内皮細胞 / CEC / AP-1 / TAK-1 / NF-κB / 播種性血管愛凝固症候群 / DIC |
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| Research Abstract |
Sepsis is a severe disorder as systemic inflammation with infection. In this illness, vascular endothelial damage proceeds to induce disseminated intravascular coagulation(DIC). This study revealed that circulating endothelial cell(CEC) was increased and plasma platelet count was decreased in the time dependent manner after sepsis induction by cecal ligation and puncture in male BALB-C mice. Nuclear factor-kappaB decoy oligonucleotides more strongly decreased CEC count than inactivation of FADD, TAK-1, and activator protein-1. The CEC count could be a reliable marker to evaluate DIC and dysfunction of vascular endothelium.
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