2012 Fiscal Year Final Research Report
Analysis of benefits of dental pulp stem cells from permanent and milk teeth for the treatment of the intractable diseases and of their banking system.
| Project/Area Number |
21390524
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
UEDA Minoru 名古屋大学, 医学系研究科, 教授 (00151803)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Akihito 名古屋大学, 大学院・医学系研究科, 准教授 (50244083)
TANAKA Miturou 岩手医科大学, 歯学部, 教授 (10143596)
KUNISADA Takahiro (30205108)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 歯髄幹細胞 / セルバンク / 再生医療 / 難治性疾患治療 |
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| Research Abstract |
According to the development of the cell banking technology, weestablished a system that allows to quickly prepare dental pulp stem cell for transplantation into the diseased area. Furthermore, we found remarkable therapeutic benefits of serum free conditioned media (CM) of the dental pulp stem cells for treatment of the various intractable diseases, including cerebral infraction, severe bone defects, spinal cordinjury and fulminant hepatic failure. Our study demonstrate a marked advantage of newly developed cell banking system and therapeutic benefits of the dental pulp stem cells and their CMs for treatment of the multiple refractory diseases.
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