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2012 Fiscal Year Final Research Report

Analysis of benefits of dental pulp stem cells from permanent and milk teeth for the treatment of the intractable diseases and of their banking system.

Research Project

  • PDF
Project/Area Number 21390524
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionNagoya University

Principal Investigator

UEDA Minoru  名古屋大学, 医学系研究科, 教授 (00151803)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Akihito  名古屋大学, 大学院・医学系研究科, 准教授 (50244083)
TANAKA Miturou  岩手医科大学, 歯学部, 教授 (10143596)
KUNISADA Takahiro   (30205108)
Project Period (FY) 2009 – 2012
Keywords歯髄幹細胞 / セルバンク / 再生医療 / 難治性疾患治療
Research Abstract

According to the development of the cell banking technology, weestablished a system that allows to quickly prepare dental pulp stem cell for transplantation into the diseased area. Furthermore, we found remarkable therapeutic benefits of serum free conditioned media (CM) of the dental pulp stem cells for treatment of the various intractable diseases, including cerebral infraction, severe bone defects, spinal cordinjury and fulminant hepatic failure. Our study demonstrate a marked advantage of newly developed cell banking system and therapeutic benefits of the dental pulp stem cells and their CMs for treatment of the multiple refractory diseases.

  • Research Products

    (8 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Conditioned media from mesenchymal stem cells enhanced bone regeneration in rat calvarial bone defects2012

    • Author(s)
      M. Osugi, W. Katagiri, R. Yoshimi, T. Inukai, H. Hibi and M. Ueda
    • Journal Title

      Tissue Engineering Part A

      Volume: Vol.18, No.13-14 Pages: 1479-1489

    • Peer Reviewed
  • [Journal Article] Viable cryopreserving tissue-engineered cell-biomaterial for cell banking therapy in an effective cryoprotectant2011

    • Author(s)
      E. Umemura, Y. Yamada, S. Nakamura, K. Ito, K. Hara and M. Ueda
    • Journal Title

      Journal of Tissue Engineering, Part C, Methods

    • Peer Reviewed
  • [Journal Article] Dental Pulp Derived CD31-/CD146- Side Population Stem/Progenitor Cells Enhance Recovery of Focal Cerebral Ischemia in Rats2010

    • Author(s)
      M. Sugiyama, K. Iohara, H. W. H. Hattori,M. Ueda, K. Matsushita, M. Nakashima
    • Journal Title

      Tissue engineering part A

    • Peer Reviewed
  • [Presentation] Conditioned media from bone marrow derived mesenchymal stem cells and adipose derived stem cells enhanced bone regeneration in rat calvarial bone defects2012

    • Author(s)
      M. Osugi, W. Katagiri, R. Yoshimi, T. Inukai, T. Kawai, H. Hibi and M. Ueda
    • Organizer
      3rd TERMIS World Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      20120905-08
  • [Presentation] Characterized Studies for SHED Compared to BMMSCs by Genes Profiling2010

    • Author(s)
      K. Hara, Y. Yamada, S. Nakamura, Y. Nishino, E. Umemura, T. Inukai, K. Ito, W. Katagiri, M. Ueda
    • Organizer
      The Japanese Society of Oral and Maxillofacial Surgeons 55th Congress and Workshop, Award for excellence of oral presentation
    • Place of Presentation
      千葉(幕張メッセ)
    • Year and Date
      2010-10-18
  • [Patent(Industrial Property Rights)] Using culture conditioned medium for cerebral infarction and brain regeneration2011

    • Inventor(s)
      M. Ueda, H. Hattori, M. Sugiyama, T. Inoue
    • Industrial Property Number
      61/437,697(US)
    • Filing Date
      2011-01-31
    • Overseas
  • [Patent(Industrial Property Rights)] Composition for treatment of damaged part2011

    • Inventor(s)
      M. Ueda, Y. Yamada, K. Ebisawa, A. Yamamoto, K. Sakai, K. Matsubara, H. Hattori, M. Sugiyama and T. Inoue
    • Industrial Property Number
      WO 2011/118795
    • Filing Date
      2011-09-29
    • Overseas
  • [Patent(Industrial Property Rights)] Dental pulp stem cells derived composites for neuronal disease treatment

    • Inventor(s)
      M. Ueda, A. Yamamoto, K. Sakai
    • Industrial Property Number
      2010-092585(2010)

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Published: 2014-08-29   Modified: 2016-01-05  

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