2011 Fiscal Year Final Research Report
Identification of Cancer Stem Cell and its niche system in Oral Cancer
| Project/Area Number |
21390539
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OKAMOTO Tetsuji 広島大学, 大学院・医歯薬学総合研究科, 教授 (00169153)
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| Co-Investigator(Kenkyū-buntansha) |
TORATANI Shigeaki 広島大学, 病院, 講師 (90172220)
HAYASHIDOU Yasutaka 広島大学, 病院, 講師 (70243251)
SHINTANI Tomoaki 広島大学, 病院, 助教 (90403518)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 口腔癌 / 癌幹細胞 / 無血清培地 / CD133 / Sp細胞 / 低酸素 / sphere形成 / 造腫瘍性 |
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| Research Abstract |
We have revealed that CD133-positive cells in oral squamous cell carcinoma cells has an important role for the sphere formation and side population cells also function for tumorigenicity and drug-resistance activity. In addition, epidermal growth factor, sonic hedgehog, interleukin-6 derived from the OSCC work as niche for the maintenance and property of CD133 cells. These results strongly suggested the possibility that CD133 and/ or Sp cells function as a cancer stem cell in oral squamous cell carcinomas. Thus, targeted therapy against the CD133 and/ or Sp cell might be useful for the OSCC therapy
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