2011 Fiscal Year Final Research Report
The possible role of autophagy in craniofacial development
| Project/Area Number |
21390547
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
YAMASHIRO Takashi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70294428)
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| Co-Investigator(Kenkyū-buntansha) |
YABUUCHI Toshinori 岡山大学, 岡山大学病院, 医員 (00452582)
KAWABE Noriaki 岡山大学, 岡山大学病院, 講師 (00397879)
NAKAGAWA Ichiro 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (70294113)
KUROSAKA Hiroshi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00397879)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUSHIMA Noboru 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10353434)
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| Project Period (FY) |
2009 – 2011
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| Keywords | オートファジー / 口蓋の形成 / 口蓋突起 / 骨組織 / ERストレス / ATG5 / LC3 |
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| Research Abstract |
Autophagy is a bulk protein degradation system and important for various physiological processes such as cell survival under starvation, development, immune responses, tumor suppression, and antiaging. The present study demonstrated that autophagy is involved in the palatal fusion in palatogenesis. Our study also indicated autophagy is also involved in osteogeneis and suggested that autopahgy might regulate the ER stress responses presumably to maintain cellular homeostasis.
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