Integrated study on mechanism of development and disorder of masticatory and swallowing function and visualization of neural circuits

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390549
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Nagasaki University
• Principal Investigator: YOSHIDA Noriaki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40230750)
• Co-Investigator(Kenkyū-buntansha): KOGA Yoshiyuki 長崎大学, 医学部・歯学部附属病院, 講師 (50175329) ; KITAURA Hideki 長崎大学, 医歯薬学総合研究科, 助教 (60295087) ; TANAKA Motohiro 長崎大学, 医歯薬学総合研究科, 助教 (90420629)
• Co-Investigator(Renkei-kenkyūsha): UTSUMI Kai 長崎大学, 医歯薬学合研究科, 助教 (80622604) ; INOUE Tomio 昭和大学, 歯学部, 教授 (70184760) ; ENOUE Makoto 新潟大学, 医歯学系, 教授 (00303131) ; 岡安 一郎 長崎大学, 医学部・歯学部附属病院, 助教 (80346923)
• Project Period (FY): 2009 – 2011
• Keywords: 咀嚼 / 嚥下 / 発達 / 障害

Research Abstract

A process of development of masticatory and swallowing function was elucidated. As a result, it was suggested that the critical period of development of those functions was beyond 6 weeks of age in mice. Regarding the mechanism of disorder of masticatory and swallowing function, the formation of an abnormal central pattern generator is unlikely to occur. Such a disturbance may be produced at the site inferior to the central pattern generator. The obtained results indicated that neural circuits controlling jaw and tongue movements have a mutual interaction.

Research Products

• [Journal Article] Effects of chewing efforts on the sensory and pain thresholds in human facial skin (2012)
  • Author(s): Okayasu I, Komiyama O, Yoshida N, Oi K, De Laat A
  • Journal Title: Arch Oral Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice (2012)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
  • Journal Title: Arch Oral Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid (2012)
  • Author(s): Sirisoontorn I, Hotokezaka H, Hashimoto M, Gonzales C, Luppanapornlarp S, Darendeliler MA, Yoshida N
  • Journal Title: Am J Orthod Dentofac Volume: (in press)
  • Peer Reviewed
• [Journal Article] Motor coorination of masseter and temporalis muscle during mastication in mice (2011)
  • Author(s): Utsumi D, Nakamura A, Matsuo K, Zeredo JL, Koga Y, Yoshida N
  • Journal Title: J Stomat Occ Med Volume: 3(4) Pages: 187-194
  • Peer Reviewed
• [Journal Article] The effects of fluoride intake on orthodontic tooth movement and on orthodontically induced root resorption (2011)
  • Author(s): Gonzales C, Hotokezaka H, Karadeniz EI, Miyazaki T, Kobayashi ET, Drrendeliler MA, Yoshida N
  • Journal Title: Am J Orthod Dentofac Volume: 139(2) Pages: 196-205
  • Peer Reviewed
• [Journal Article] Tooth movement and root resorption ; The effect of ovariectomy on orthodontic force application in rats (2011)
  • Author(s): Sirisoontorn I, Hotokezaka H, Hashimoto M, Gonzales C, Luppanapornlarp S, Darendeliler MA, Yoshida N
  • Journal Title: Angle Orthod Volume: 81 Pages: 570-577
  • Peer Reviewed
• [Journal Article] IFN-γdirectly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/ Fas ligand interactions (2011)
  • Author(s): Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Masuyama R, Yoshida N
  • Journal Title: Immunol Lett Volume: 137(1-2) Pages: 53-61
  • Peer Reviewed
• [Journal Article] Takano-Yamamoto T : IL-12-and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Masuyama R, Yoshida N
  • Journal Title: Calcified Tissue Int Volume: 89(1) Pages: 65-73
  • Peer Reviewed
• [Journal Article] Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis, upper cervical cord, NTS and Pa5 following capsaicin injection into masticatory and swallowing-related muscles in rats (2011)
  • Author(s): Tsujimura T, Shinoda M, Honda K, Hitomi S, Kiyomoto M, Matsuura S, Katagiri A, Tsuji K, Inoue M, Shiga Y, Iwata K
  • Journal Title: Brain Res Volume: 12(1417) Pages: 45-54
  • Peer Reviewed
• [Journal Article] Decreased intake of sucrose solutions in orexin knockout mice (2011)
  • Author(s): Matsuo E, Mochizuki A, Inoue T
  • Journal Title: J Mol Neurosci Volume: 43(2) Pages: 217-24
  • Peer Reviewed
• [Journal Article] The nucleus locus coeruleus/ subcoeruleus contributes to antinociception during freezing behavior following the air-puff startle in rats (2011)
  • Author(s): Tsuruoka M, Tamaki J, Maeda M, Hayashi B, Inoue T
  • Journal Title: Brain Res Volume: 1393 Pages: 52-61
  • Peer Reviewed
• [Journal Article] IL-18 inhibits TNF-alpha-induced osteoclastogenesis possibly via a T cell-independent mechanism in synergy with IL-12 in vivo (2010)
  • Author(s): Morita Y, Kitaura H, Yoshimatsu M, Fujimura Y, Kohara H, Eguchi T, Yoshida N
  • Journal Title: Calcified Tissue Int Volume: 86(3) Pages: 242-248
  • Peer Reviewed
• [Journal Article] Repair of root resorption 2 to 16 weeks after the application of continuous forces on maxillary first molars in rats : a 2-and 3-dimensional quantitative evaluation (2010)
  • Author(s): Gonzales C, Hotokezaka H, Darendeliler MA, Yoshida N
  • Journal Title: Am J Orthod Dentofac Volume: 137(4) Pages: 477-485
  • Peer Reviewed
• [Journal Article] Properties of synaptic transmission from the reticular formation dorsal to the facial nucleus to trigeminal motoneurons during early postnatal development in rats (2010)
  • Author(s): Gemba-Nishimura A, Inoue T
  • Journal Title: Neuroscience Volume: 166 Pages: 1008-1022
  • Peer Reviewed
• [Journal Article] 自由行動下マウスを用いた咀嚼時筋活動様式の検討 (2010)
  • Author(s): 黒瀬直子, 黒瀬雅之, 山村健介, 高辻華子, 内海大, 山田好秋
  • Journal Title: 日咀嚼誌 Volume: 20(2) Pages: 113-120
  • Peer Reviewed
• [Journal Article] Measuring biting behavior induced by acute stress in the rat (2009)
  • Author(s): Zeredo JL, Kumei Y, Shibazaki T, Yoshida N, Toda K
  • Journal Title: Behav Res Methods Volume: 41(3) Pages: 761-764
  • Peer Reviewed
• [Journal Article] Effect of celecoxib on emotional stress and pain-related behaviors evoked by experimental tooth movement in the rat (2009)
  • Author(s): Shibazaki T, Yozgatian JH, Zeredo JL, Gonzales C, Hotokezaka H, Koga Y, Yoshida N
  • Journal Title: Angle Orthod Volume: 79(6) Pages: 1169-1174
  • Peer Reviewed
• [Journal Article] IL-12 inhibits TNF-αinduced osteoclastogenesis via a T cell-independent mechanism in vivo (2009)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Eguchi T, Kohara H, Morita Y, Yoshida N
  • Journal Title: Bone Volume: 45(5) Pages: 1010-1016
  • Peer Reviewed
• [Journal Article] Influence of bisphosphonates on orthodontic tooth movement in mice (2009)
  • Author(s): Fujimura Y, Kitaura H, Yoshimatsu M, Eguchi T, Kohara H, Morita Y, Yoshida N
  • Journal Title: Eur J Orthod Volume: 31(6) Pages: 572-577
  • Peer Reviewed
• [Journal Article] Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar (2009)
  • Author(s): Gonzales C, Hotokezaka H, Matsuo K, Shibazaki T, Yozgatian JH, Drrendeliler MA, Yoshida N
  • Journal Title: Angle Orthod Volume: 79(4) Pages: 715-726
  • Peer Reviewed
• [Journal Article] An in vivo 3D micro-CT evaluation of tooth movement after the application of different force magnitudes in rat molar (2009)
  • Author(s): Gonzales C, Hotokezaka H, Arai Y, Ninomiya T, Tominaga J, Insan J, Hotokezaka Y, Tanaka M, Yoshida N
  • Journal Title: Angle Orthod Volume: 79(4) Pages: 703-714
  • Peer Reviewed
• [Journal Article] Afferent connections of the parabrachial nucleus in C57BL/ 6J mice (2009)
  • Author(s): Tokita K, Inoue T and Boughter Jr JD
  • Journal Title: Neuroscience Volume: 161 Pages: 475-488
  • Peer Reviewed
• [Presentation] Effects of IFN-γon orthodontic tooth movement (2011)
  • Author(s): Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
  • Organizer: The 4th international congress & the 70th annual meeting of the Japanese orthodontic society
  • Place of Presentation: Nagoya
  • Year and Date: 20111017-20
• [Presentation] IL-12-and IL-18-mediated nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Yoshida N, Takano-Yamamoto T
  • Organizer: The 4th international congress & the 70th annual meeting of the Japanese orthodontic society
  • Place of Presentation: Nagoya
  • Year and Date: 20111017-20
• [Presentation] Effects of SHIP on TNF-alpha-induced osteoclastogenesis (2011)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
  • Organizer: The 4th international congress & the 70th annual meeting of the Japanese orthodontic society
  • Place of Presentation: Nagoya
  • Year and Date: 20111017-20
• [Presentation] Effect of zoledronic acid by systemic administration on orthodontically induced root resorption in ovariectomized rats (2011)
  • Author(s): Sirisoontorn I, Hotokezaka H, Hashimoto M, Nakano T, Yoshida N
  • Organizer: The 4th international congress & the 70th annual meeting of the Japanese orthodontic society
  • Place of Presentation: Nagoya
  • Year and Date: 20111017-20
• [Presentation] Effects of chewing efforts on the sensory and pain thresholds in human facial skin (2011)
  • Author(s): Okayasu I、Komiyama O, Yoshida N, Oi K, De Laat A
  • Organizer: The 27th Store Kro Club conference
  • Place of Presentation: Turin, Italy
  • Year and Date: 20110500
• [Presentation] 交叉咬合モデルマウスを用いた顎口腔領域における形態変化と機能発達の関連性の解明 (2011)
  • Author(s): 中村文, 内海大, 松尾恭子, 田中基大, 古賀義之, 吉田教明
  • Organizer: 第46回日本顎口腔機能学会
  • Place of Presentation: 仙台
  • Year and Date: 20110500
• [Presentation] Effects of chewing efforts on the sensory and pain perception in human facial skin (2010)
  • Author(s): 岡安一郎, 吉田教明, 大井久美子, 小見山道, Antoon DeLaat
  • Organizer: 第45回日本顎口腔機能学会
  • Place of Presentation: 川越
  • Year and Date: 20101100
• [Presentation] 不正咬合モデルマウスを用いた顎口腔領域における形態変化と機能発達の関連性の解明 (2010)
  • Author(s): 中村文, 松永淳子, 内海大, 松尾恭子, 田中基大, 古賀義之, 吉田教明
  • Organizer: 第69回日本矯正歯科学会大会・第3回日韓ジョイントミーティング
  • Place of Presentation: 横浜
  • Year and Date: 20100900
• [Presentation] シンポジウム「顎口腔機能評価のガイドライン」 (2010)
  • Author(s): 吉田教明
  • Organizer: 矯正患者の機能評価のガイドライン,日本顎口腔機能学会第44回学術大会
  • Place of Presentation: 広島
  • Year and Date: 20100400
• [Presentation] Coordination of masseter and temporalis muscles during mastication in mice (2010)
  • Author(s): Utsumi D, Koga Y, Tanaka M, Matsuo K, Nakamura A, Yoshida N
  • Organizer: 7th International Orthodontic Congress
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20100206-09
• [Presentation] IL-12 Inhibits TNF-α-mediated Osteoclastogenesis via a T-cell-independent Mechanism (2009)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Takano-Yamamoto T, Yoshida N
  • Organizer: The 31th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Denver, USA
  • Year and Date: 20090911-15
• [Presentation] IFN-γ-mediated Nitric Oxide Inhibits Proliferation of M-CSF-dependent Bone Marrow Macrophages (2009)
  • Author(s): Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Takano-Yamamoto T, Yoshida N
  • Organizer: The 31th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Denver, USA
  • Year and Date: 20090911-15
• [Presentation] 食品の性状の違いによるマウス咀嚼運動の変化について (2009)
  • Author(s): 内海大, 松尾恭子, 田中基大, 古賀義之, 吉田教明
  • Organizer: 第42回日本顎口腔機能学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 20090400
• [Book] 最大咬合力,咀嚼経路の安定性,および咀嚼リズムの安定性と咀嚼能率との関係について(顎口腔機能の評価 (2010)
  • Author(s): 郡司良律, 小嶺祐子, 寺辺やよひ, 中村文, 鈴木善貴, 竹尾健吾, 福原孝子, 福本宗子, 田中佑人, 大河貴久, 依田信裕, 渡辺一彦, 井上富雄, 瑞森崇弘, 志賀博, 早崎治明, 丸山智章, 荒川一郎, 横山正起, 坂口究
  • Total Pages: 82-86
  • Publisher: 日本顎口腔機能学会編
• [Remarks]
  • URL: http://ortho.dh.nagasaki-u.ac.jp/index02.html