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2012 Fiscal Year Final Research Report

International Investigation on the Frontier of Early Detection and Social Treatment for Dementia Patients

Research Project

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Project/Area Number 21404002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Medical systems
Research InstitutionOkayama University

Principal Investigator

WU Jinglong  岡山大学, 大学院・自然科学研究科, 教授 (30294648)

Co-Investigator(Kenkyū-buntansha) TOUGE Tetsuo  香川大学, 医学部, 教授 (80197839)
Co-Investigator(Renkei-kenkyūsha) FUKUYAMA Hidenao  京都大学, 大学院・医学研究科, 教授 (90181297)
TAKAHASHI Satoshi  岡山大学, 大学院・自然科学研究科, 准教授 (20236277)
YANG Jiajia  岡山大学, 大学院・自然科学研究科, 助教 (30601588)
Project Period (FY) 2009 – 2012
Keywords認知症 / 早期診断 / 脳波 / 画像診断 / fMRI / 視覚 / 聴覚 / 触覚
Research Abstract

In order to achieve the early diagnosis of dementia, the following researches were implemented:
(1) investigation and research of dementia abroad
(2) proposal of dementia diagnostic technology of international standards,and
(3) recommendations of dementia social measures
Through cooperation with co-worker and dementia-related foreign researchers, the cognitive experiments on dementia have been carried out and the results have also been discussed. Particularly, significant differences were found about tactile cognitive function between dementia patients and healthy elderly individuals. These results could be valid in the early diagnosis of dementia. Based on the network that was constructed according to our studies and results, the preparation for international large-scale experiments could continue to advance.

  • Research Products

    (38 results)

All 2012 2011 2010 2009 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (10 results) Remarks (6 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Prominent Activation of the Intraparietal and Somatosensory Areas during Angle Discrimination by Intra-Active Touch2012

    • Author(s)
      Jiajia Yang, Hongbin Han, Dehua Chui, Yong Shen, Jinglong Wu
    • Journal Title

      Human Brain Mapping

      Volume: Vol.33, No.12 Pages: 2957-2970

    • Peer Reviewed
  • [Journal Article] Delayed Audiovisual Integration of Patients with Mild Cognitive Impairment and Alzheimer's Disease Compared with Normal Aged Controls2012

    • Author(s)
      Jinglong Wu, Jiajia Yang, Yinghua Yu, Yong Shen, Yasuyuki Ohta, Shengyuan Yu, Koji Abe
    • Journal Title

      ournal of Alzheimer Disease

      Volume: Vol.32 Pages: 317-328

    • Peer Reviewed
  • [Journal Article] Age-related multisensory integration elicited by peripherally presented audiovisual stimuli2012

    • Author(s)
      Jinglong Wu, Weiping Yang, Yulin Gao, Takahiro Kimura
    • Journal Title

      NeuroReport

      Volume: vol.23 Pages: 616-620

    • Peer Reviewed
  • [Journal Article] Retinotopic Mapping of the Peripheral Visual Field to Human Visual Cortex by Functional Magnetic Resonance Imaging2012

    • Author(s)
      Jinglong Wu, Tianyi Yan, Zhen Zhang, Fengzhe Jin, Qiyong Guo
    • Journal Title

      Human Brain Mapping

      Volume: Vol.33, Issue 7 Pages: 1727-174

    • Peer Reviewed
  • [Journal Article] The Ebbinghaus Illusion Affects Visual Size Perception But Not Pointing Movement2012

    • Author(s)
      Jiajia Yang, Disuke Oka, Jinglong Wu
    • Journal Title

      Information

      Volume: Vol.15(4) Pages: 1799-1808

    • Peer Reviewed
  • [Journal Article] Prominent activation of the bilateral inferior parietal lobule of literate compared with illiterate subjects during Chinese logographic processing2012

    • Author(s)
      Jinglong Wu, Xiujun Li, Jiajia Yang, Chang Cai, Hongzan Sun, Qiyong Guo
    • Journal Title

      Experimental Brain Research

      Volume: Vol.219 Pages: 327-337

    • Peer Reviewed
  • [Journal Article] Programmable Tactile Pattern Presentations Operational under MRI to Investigate Neural Mechanisms of Tactile Shape Discrimination2011

    • Author(s)
      Jiajia Yang, Jinglong Wuand Jiping He
    • Journal Title

      Journal of Neuroscience Methods

      Volume: Vol.201 Pages: 17-26

    • Peer Reviewed
  • [Journal Article] The Contribution of Pinna Cues to Human Sound Discriminate Ability of Vertical Angle in Sagittal Planes2011

    • Author(s)
      Tianyi Yan and Jinglong Wu
    • Journal Title

      Information

      Volume: Vol.14, No.10 Pages: 3555-3566

    • Peer Reviewed
  • [Journal Article] Neural Substrates of Priming Effect for Japanese Word and Nonword when Compared to Figure Form2011

    • Author(s)
      Chunlin Li, Xiujun Li, Hiroshi Kusahara and Jinglong Wu
    • Journal Title

      Information

      Volume: Vol.14, No.8 Pages: 2911-2924

    • Peer Reviewed
  • [Journal Article] Spatial Attention Improve Performance of Pointing Movement2011

    • Author(s)
      Jiajia Yang, Motohiko Omodani and Jinglong Wu
    • Journal Title

      Information

      Volume: Vol.14, No.6 Pages: 2009-2017

    • Peer Reviewed
  • [Journal Article] Development of A Wide-view Visual Presentation System for Visual Retinotopic Mapping during functional MRI2011

    • Author(s)
      Tianyi Yan, Fengzhe Jin, Jiping He and Jinglong Wu
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: Vol.33(2) Pages: 441-447

    • Peer Reviewed
  • [Journal Article] Decline of Human Tactile Angle Discrimination in patients with Mild Cognitive Impairment and Alzheimer's Disease2010

    • Author(s)
      Jiajia Yang, Takashi Ogasa, Yasuyuki Ohta, Koji Abe and Jinglong Wu
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: Vol.22 No.1 Pages: 225-234

    • Peer Reviewed
  • [Journal Article] Development and Evaluation of a Multi-Model Tactile Pattern Delivery Device for fMRI Study2010

    • Author(s)
      Jiajia Yangand Jinglong Wu
    • Journal Title

      Information

      Volume: Vol.13, No.5 Pages: 1823-1832

    • Peer Reviewed
  • [Journal Article] An Event-Related Study for Dynamic Analysis of Corticomuscular Connectivity2010

    • Author(s)
      Ou Bai, Dandan Huang, Peter Lin, Jinglong Wu, Xuedong Chen and Ding-Yu Fei
    • Journal Title

      Biomedical Engineering and Computational Biology

      Volume: Vol.2 Pages: 1-10

    • Peer Reviewed
  • [Journal Article] Raised Angle Discrimination under Passive Hand Movement2010

    • Author(s)
      Jinglong Wu, Jiajia Yangand Takashi Ogasa
    • Journal Title

      Perception

      Volume: Vol. 39 No. 7 Pages: 993-1006

    • Peer Reviewed
  • [Journal Article] Multimodal Audiovisual Integration at Early and Late Processing Stages in Humans: An Event-Related Potential Study2010

    • Author(s)
      Qi Li, Jingjing Yang, Noriyoshi Kakura and Jinglong Wu
    • Journal Title

      Information

      Volume: Vol.13 No.3(A) Pages: 807-816

    • Peer Reviewed
  • [Journal Article] Fitts' Law Holds for Pointing Movements under Conditions of Restricted Visual Feedback2010

    • Author(s)
      Jinglong Wu, Jiajia Yangand Taichi Honda
    • Journal Title

      Human Movement Science

      Volume: Vol.29 Issue.6 Pages: 882-892

    • Peer Reviewed
  • [Journal Article] Audiovisual interaction enhances auditory detection in late stage: an event-related potential study2010

    • Author(s)
      Qi Li, Jinglong Wuand Tetsuo Touge
    • Journal Title

      Neuroreport

      Volume: Vol.21 No.3 Pages: 173-178

    • Peer Reviewed
  • [Journal Article] Reversible alcohol-related dementia: a five-year follow-up study using FDG-PET and neuropsychological tests2010

    • Author(s)
      Asada T, Takaya S, Takayama Y, Yamauchi H, Hashikawa K,Fukuyama H
    • Journal Title

      Internal Medicine

      Volume: Vol.49, No.4 Pages: 283-287

    • Peer Reviewed
  • [Journal Article] Investigation on Human Visual and Auditory Calculation Mechanism by Event Related Potential2010

    • Author(s)
      Jinglong Wuand Noriyosi Kakura
    • Journal Title

      Information

      Volume: Vol.13 No.1 Pages: 99-109

    • Peer Reviewed
  • [Presentation] Aging effect on pedal errors of driving under different visual conditions2012

    • Author(s)
      Masayuki Yoshitake, Jiajia Yang, Jinglong Wu
    • Organizer
      International Conference on Advanced Mechatronic systems (ICAMechS2012)
    • Place of Presentation
      東京
    • Year and Date
      2012-09-19
  • [Presentation] actile and Audiovisual Approach for Early Detection of Alzheimer's Disease2012

    • Author(s)
      Jinglong Wu
    • Organizer
      The 2012 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2012)
    • Place of Presentation
      岡山
    • Year and Date
      2012-03-01
  • [Presentation] 触覚角度弁別を用いたアルツハイマー型認知症スクリーニング検査方法の開発2011

    • Author(s)
      楊家家,太田康之,阿部康二,呉景龍
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20111111-13
  • [Presentation] Early Detection of Patients with Mild Cognitive Impairment and Alzheimer's Disease using a Novel Tactile Approach2011

    • Author(s)
      Jiajia Yang, Yinghua Yu, Yong Shen, Yasuyuki Ohta, Koji Abe, Jinglong Wu
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease (AAICAD)
    • Place of Presentation
      フランス
    • Year and Date
      20110700
  • [Presentation] Audiovisual Integration of Normal aged Controls Compared to Patients with Mild Cognitive Impairment and Alzheimer's Disease2011

    • Author(s)
      Jinglong Wu, Jiajia Yang, Naoya Nakamura, Qi Li, Yong Shen, Yasuyuki Ohta, Koji Abe
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease (AAICAD)
    • Place of Presentation
      フランス
    • Year and Date
      20110700
  • [Presentation] An International Investigation of Social Circumstances and Driver Licenses for Elder Persons2011

    • Author(s)
      Satoshi Takahashi, Jinglong Wu
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering (CME2011)
    • Place of Presentation
      中国
    • Year and Date
      20110500
  • [Presentation] Frontiers in Neuromedical Engineering2010

    • Author(s)
      Jinglong Wu
    • Organizer
      2010 IEEE/CME International Conference on Complex Medical Engineering(CME2010)
    • Place of Presentation
      オーストラリア
    • Year and Date
      2010-07-15
  • [Presentation] Excitability changes of corticospinal pathways by magnetic brain stimulation during the maximum voluntary muscle contraction2009

    • Author(s)
      Touge Tetsuo
    • Organizer
      2009 IEEE/CME International Conference on Complex Medical Engineering (CME2009)
    • Place of Presentation
      アメリカ
    • Year and Date
      20090409-11
  • [Presentation] Development of a Dual Tactile Pattern Presentation Device using in MRI Environment2009

    • Author(s)
      Jiajia Yang, Jinglong Wu, Dehua Chui and Hongbin Han
    • Organizer
      2009 IEEE/CME International Conference on Complex Medical Engineering (CME2009)
    • Place of Presentation
      アメリカ
    • Year and Date
      20090409-11
  • [Presentation] Neuroimaging in Alzheimer's disease2009

    • Author(s)
      Hidenao Fukuyama
    • Organizer
      2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia (DRD2009)
    • Place of Presentation
      岡山
    • Year and Date
      2009-12-12
  • [Remarks] (1)アルツハイマー「く」の字識別で診断, 日本経済新聞, 2012.6.5

  • [Remarks] (2)進化が磨いた高感度センサー 触覚で早期発見 認知症, NHK サイエンスゼロ, 2010.9.25

  • [Remarks] (3)でこぼこ触って認知症を診断, 朝日新聞, 2010.7.29

  • [Remarks] (4)認知症を"一発診断" 図形触って角度識別, 讀賣新聞, 2010.7.29

  • [Remarks] (5)「く」の字触り認知症を検査, 中國新聞, 2010.7.29

  • [Remarks] (6)認知症早期発見に光 「く」形突起触れ角度識別, 山陽新聞, 2010.7.29

  • [Patent(Industrial Property Rights)] 認知症の発症の有無を確認するために刺激を提供する装置及び認知症の発症の有無を確認するための方法2012

    • Inventor(s)
      呉景龍,楊家家
    • Industrial Property Rights Holder
      呉景龍,楊家家
    • Industrial Property Number
      特許2012-060879
    • Filing Date
      2012-03-16
  • [Patent(Industrial Property Rights)] 認知症の発症の有無を確認するための方法及び装置2011

    • Inventor(s)
      呉景龍, 阿部康二
    • Industrial Property Rights Holder
      呉景龍, 阿部康二
    • Industrial Property Number
      特許2010-271373
    • Filing Date
      2011-12-06

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Published: 2014-08-29  

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