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2011 Fiscal Year Final Research Report

Search for the epigenetic transcription factor related to fear extinction

Research Project

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Project/Area Number 21500344
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionChiba University

Principal Investigator

SHIMIZU Eiji  千葉大学, 大学院・医学研究院, 教授 (00292699)

Project Period (FY) 2009 – 2011
Keywords恐怖消去 / 感覚ゲート機構 / NMDA受容体 / DNAメチル化 / 調整誘発電位P50
Research Abstract

To investigate what the change of DNA methylation in the brain alter behavior, mice were fed with methyl donor deficient diet in their 3wk to 6wk age. Difference in expression of NMDA receptor NR2B subunit in the hippocampus was considered as a cause of the behavioral change after the diet. In human, our results suggested that auditory evoked potential P50 differed according to the cognition of the properties (potentially dangerous or safe) of the perceived signal.

  • Research Products

    (10 results)

All 2012 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] P50 suppression in human discrimination fear conditioning paradigm using danger and safety signals2012

    • Author(s)
      Kurayama T, Matsuzawa D, Komiya Z, Nakazawa K, Yoshida S, Shimizu E
    • Journal Title

      International Journal of Psychophysiology

      Volume: 84(1) Pages: 26-32

    • DOI

      DOI:10.1016/j.ijpsycho.2012.01.004

    • Peer Reviewed
  • [Journal Article] Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway2010

    • Author(s)
      Ishii D, Matsuzawa D, Kanahara N , Matsuda S, Sutoh C, Ohtsuka H, Nakazawa K, Kohno M, Hashimoto K, Iyo M, Shimizu E
    • Journal Title

      Neuroscience Letters

      Volume: 471(1) Pages: 53-57

    • DOI

      DOI:10.1016/j.neulet.2010.01.010

    • Peer Reviewed
  • [Journal Article] Impaired P50 suppression in fear extinction in obsessive-compulsive disorder2009

    • Author(s)
      Nanbu M, Kurayama T, Nakazawa K, Matsuzawa D , Komiya Z, Haraguchi T, Ogura H, Hashimoto T, Yoshida S, Iyo M, Shimizu E
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 34(2) Pages: 317-22

    • DOI

      DOI:10.1016/j.pnpbp.2009.12.005

    • Peer Reviewed
  • [Presentation] 不安障害の曝露療法の生物学と新薬の開発2012

    • Author(s)
      清水栄司
    • Organizer
      第13回日本サイコセラピー学会(シンポジウム)
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      20120317-18
  • [Presentation] 強迫性障害の診断と治療2011

    • Author(s)
      清水栄司
    • Organizer
      第1回埼玉うつ・不安障害治療研究会埼玉精神神経センター
    • Year and Date
      2011-11-10
  • [Presentation] OCDの病態仮説と治療理論OCDの事象関連電位と感覚ゲート機構心理職とのこれからの協働を考える専門的治療(認知行動療法)の立場から2010

    • Author(s)
      清水栄司
    • Organizer
      第106回日本精神神経学会学術総会広島国際会議場
    • Place of Presentation
      広島
    • Year and Date
      20100520-0522
  • [Presentation] Effects of methionine, choline and folic acid-deficient diet at the developmental period on anxiety and fear in mice2010

    • Author(s)
      石井大典
    • Organizer
      第40回NEUROSCIENCE 2010
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      2010-11-13
  • [Presentation] パニック障害の診断と治療2010

    • Author(s)
      清水栄司
    • Organizer
      パニック障害セミナー
    • Place of Presentation
      札幌
    • Year and Date
      2010-08-28
  • [Presentation] パニック障害の認知行動療法2010

    • Author(s)
      清水栄司
    • Organizer
      第6回うつ病・不安障害フォーラム西鉄グランドホテル
    • Place of Presentation
      福岡
    • Year and Date
      2010-05-27
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/phys1/index.html

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Published: 2013-07-31  

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