2011 Fiscal Year Final Research Report
Elucidation of the natural healing mechanism after knee anterior cruciate ligament tear and it's clinical application
| Project/Area Number |
21500484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Saitama Prefectural University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANEMURA Naohiko 埼玉県立大学, 保健医療福祉学部, 講師 (20379895)
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| Co-Investigator(Renkei-kenkyūsha) |
KOKUBUN Takanori 埼玉県立大学, 保健医療福祉学部, 助教 (10616395)
NISHIKAWA Yuichi 埼玉県立大学, 大学院・保健医療福祉学研究科, 学生
IHARA Hidetoshi 労働福祉事業団九州労災病院
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| Project Period (FY) |
2009 – 2011
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| Keywords | 前十字靭帯 / 保存療法 / 動物実験モデル |
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| Research Abstract |
The natural healing of the ruptured anterior cruciate ligament(ACL) using a new animal model was observed by mechanical, histological and immunohistochemistrical methods. The ACL was cut completely by the mini-scissors and then the knee joint was controlled normally with artificial ligament. The ruptured ACL was healed in all rats. Eight weeks after ACL cutting, the Type III collagen was increased in the healing ligament. After 8 weeks and 40 weeks after the ACL cut, the healing ligament was half strength compared to the normal ligament.
The expression of MMP-1, MMP-13 and TIMP-1 in medial and lateral meniscus and rupture ACL was increased after ACL cut. Expression of MMP-13 in the joint control group has been suppressed compared to the no joint control group. It is suggested that abnormal joint movement under the gravity is increased to express of proteolytic enzymes of both meniscus and rupture ACL in the knee joint.
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