2011 Fiscal Year Final Research Report
Research of the molecular mechanism in effects of doping drugs(adrenergic agonists)
| Project/Area Number |
21500628
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
KITAURA Takashi 金沢大学, 保健管理センター, 准教授 (00143868)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | ドーピング / 筋肥大 / シグナル伝達 / アドレナリン受容体 / 薬理学 |
|---|
| Research Abstract |
Clenbuterol(CLE) is one of the beta-2 adrenergic receptor agonists with powerful muscle anabolic and lipolytic effects and is prohibited to use as doping drug for athletes. It is manufactured as a 1 : 1 racemic mixture of two enantiomers,(-)-R and(+)-S isomers.
The both enantiomers induced the increased cardiac and skeletal muscles mass.
Particularly, fast-twitch extensor digitorum longus muscle having less beta-2 adrenergic receptor was affected more strongly. The expression of MyoD mRNAs by enantiomers was different between fast and slow-twitch muscles, but the results in proteins were not synchronized with the changes of mRNAs. Furthermore, the(+)-S isomer strongly inhibited the femurs and tibiae bones.
|
