2011 Fiscal Year Final Research Report
Uranium dynamics in tissues using nano-beam elemental analysis
| Project/Area Number |
21510059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
TAKEDA Shino 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員 (00272203)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 防護 |
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| Research Abstract |
The pollution caused by the military use of depleted uranium and renewed interests in nuclear energy have raised increasing concern about uranium toxicity. The dose-response relationship between uranium accumulation and tissue damage, however, has not been demonstrated, primarily due to a lack of suitable analytical methodologies for measuring trace levels of uranium in tissues. In the present study, a method of analysis to reveal uranium localization in tissues was established using nano-beam elemental analysis and applied for uranium induced renal toxicity. Uranium selectively concentrated in the down stream of the proximal tubules more than 500-fold higher than the dose and caused renal apoptosis and lesions in the site.
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[Journal Article] Evaluation of pressed powders and thin section standards for multi-elemental analysis by conventional and micro-PIXE analysis2010
Author(s)
Homma-Takeda S, Iso H, Ito M, Suzuki K, Harumoto K, Yoshitomi T, Ishikawa T, Oikawa M, Suya N, Konishi T, and Imaseki H
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Journal Title
International Journal of PIXE
Volume: 20
Pages: 21-28
DOI
Peer Reviewed
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