2012 Fiscal Year Final Research Report
Analyses of methylarginines on the chemical communication between fetus and mother.
| Project/Area Number |
21510222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KAKO Koichiro 筑波大学, 生命環境系, 講師 (60311594)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Junji 筑波大学, 生命環境系, 講師 (30323257)
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| Project Period (FY) |
2009 – 2012
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| Keywords | アルギニンメチル化 / アミン / 高感度定量分析法 / ケミカルコミュニケーション / 生理活性アミン |
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| Research Abstract |
In the present study, we focused on two points;
1) Further analyses of the protein arginine methylation and the elucidation of intracellular processes of methyl arginine production.
2) Feto-placental-maternal pharmacokinetic monitoring of methyl arginines andrelated amines. In conclusion, we showed that the arginine methylationof DAF-16 regulates life-span of C. elegans and free-methylargines were generated through both ubiquitin-proteasome system and autophagosome system, and succeeded in identifications ofseveral amines involved in the feto-maternal chemical communications.
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[Journal Article] Estrogen regulates prostate tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.2011
Author(s)
Nakajima,Y., Akaogi,K.,Suzuki,T., Osakabe,A.,Yamaguchi,C.,Sunahara,N., Ishida,J., Kako,K.,Ogawa,S., Fujimura,T., Homma,Y., Fukamizu,A.,Murayama,A., Kimura,K., Inoue, S., Yanagisawa, J.
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Journal Title
Science Signal.
Volume: 4
Pages: ra22
DOI
Peer Reviewed
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[Journal Article] Asymmetric arginine dimethylation determines lifespan in C. elegansby regulating forkhead transcription factor DAF-16.2011
Author(s)
Takahashi, Y., Daitoku, H., Hirota,K., Tamiya, H., Yo koyama, A., Kako, K., Nagashima,Y., Nakamura, A., Shimada, T., Watanabe, S., Yamagata, K., Yasuda, K., Ishii, N. Fukamizu, A.
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Journal Title
Cell Metab.
Volume: 13
Pages: 615-620
DOI
Peer Reviewed
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[Journal Article] Production of free methylarginines via the proteasome and autophagy pathways in cultured cells.2011
Author(s)
Shirakawa, T., Kako,K., Shimada, T., Nagashima, Y., Nakamura, A., Ishida, J.,Fukamizu, A.
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Journal Title
Mol. Med. Rep.
Volume: 4
Pages: 615-620
DOI
Peer Reviewed
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