2011 Fiscal Year Final Research Report
Elucidation of natural products to regulate glucose-transporters on the small intestine
| Project/Area Number |
21510223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tokyo University of Marine Science and Technology |
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Principal Investigator |
KOYAMA Tomoyuki 東京海洋大学, 大学院・海洋科学技術研究科, 准教授 (00377904)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生物活性物質 / 機能性食品素材 |
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| Research Abstract |
Through exploratory study of the food material to suppress postprandial elevation of blood glucose level in mice, this study aimed to find and identified compounds having inhibitory effect of glucose absorption from the intestinal tract. As a result, some inhibitors against carbohydrate digestive enzymes or against glucose-transport in the intestine were purified with chromatography and then identified by spectral analysis. Multiflorin A, which was obtained from peach leaf extract, showed the most powerful effect compared with known transporter-inhibitors. Then the study of structure-activity relationship showed that its acetyl group is important to express the activity in vivo.
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[Journal Article] Peach leaf contains multiflorin A as a potent inhibitor of glucose absorption in the small intestine in mice2012
Author(s)
Shirosaki, M., Goto, Y., Hirooka, S., Masuda, H., Koyama, T., Yazawa, K.
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Journal Title
Biol. Pharm. Bull
Volume: (accepted)
Peer Reviewed
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