2011 Fiscal Year Final Research Report
Development of Novel Spin-labeled Nucleic Acids with Unique Spin and Redox Properties
| Project/Area Number |
21550158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyushu University |
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Principal Investigator |
ASO Mariko 九州大学, 大学院・薬学研究院, 准教授 (30201891)
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| Project Period (FY) |
2009 – 2011
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| Keywords | スピンラベル / 核酸 / 安定ラジカル / ESR / 運動性 |
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| Research Abstract |
Spin-labeled nucleic acids, which have N-tert-butylaminoxyl group at nucleobase, were synthesized and investigated with respect to how they can monitor the structure of nucleic acids. Adjacent and opposing nucleobases affected EPR spectra of deuplex ODN containing adenine derivative, A*. EPR spectra of B-and Z-form DNA containing A* were investigated. Synthetic studies of spin-labeled C-nucleoside were also carried out with the aim of development of a novel probe which forms base pair with adenine at aminoxyl group.
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