2011 Fiscal Year Final Research Report
Development of magnetic nanoparticles for non-invasive early diagnosis of acute myocardial infarction
| Project/Area Number |
21550165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Chubu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takeshi 中部大学, 生物機能開発研究所, 客員教授 (10043324)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ナノ材料 / 磁性 / マグネタイト / マクロファージ / 標的指向性 / 核磁気共鳴画像法(MRI) / 造影剤 / がん |
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| Research Abstract |
Ligands-bound magnetite nanoparticles(MNPs) have been expected as enhancing agents for magnetic resonance imaging(MRI). To develop MNPs for non-invasive early diagnosis of acute myocardial infarction, we prepared MNPs coated with 4-methylcatechol(4-MC) and N-vinyl-2-pyrrolidone/methyl methacrylate/methacryl acid terpolymer [P(VP-MMA-MA)] by thermal decomposition of iron pentacarbonyl, and conjugated MNPs with ligand molecules to target macrophages.
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